FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097582263> ?p ?o ?g. }

• W2097582263 endingPage "e5" @default.
• W2097582263 startingPage "e5" @default.
• W2097582263 abstract "Diminished bone density and a propensity to fracture with minimal trauma are common in children and adolescents with moderate to severe cerebral palsy (CP). The purpose of this study was to provide a detailed evaluation of bone mineral density (BMD) and metabolism in this population and to assess the relationship of these measures to multiple other clinical, growth, and nutrition variables.The study group consisted of 117 subjects ages 2 to 19 years (mean: 9.7 years) with moderate to severe CP as defined by the Gross Motor Functional Classification scale. Population-based sampling was used to recruit 62 of the participants, which allows for estimations of prevalence. The remaining 55 subjects were a convenience sampling from both hospital- and school-based sources. The evaluation included measures of BMD, a detailed anthropometric assessment of growth and nutritional status, medical and surgical history, the Child Health Status Questionnaire, and multiple serum analyses. BMD was measured in the distal femur, a site specifically developed for use in this contracted population, and the lumbar spine. BMD measures were converted to age and gender normalized z scores based on our own previously published control series (n > 250).Osteopenia (BMD z score <-2.0) was found in the femur of 77% of the population-based cohort and in 97% of all study participants who were unable to stand and were older than 9 years. BMD was not as low in the lumbar spine (population-based cohort mean +/- standard error z score: -1.8 +/- 0.1) as in the distal femur (mean z score: -3.1 +/- 0.2). Fractures had occurred in 26% of the children who were older than 10 years. Multiple clinical and nutritional variables correlated with BMD z scores, but interpretation of these findings is complicated by covariance among variables. In stepwise regression analyses, it was found that severity of neurologic impairment as graded by Gross Motor Functional Classification level, increasing difficulty feeding the child, use of anticonvulsants, and lower triceps skinfold z scores (in decreasing order of importance) all independently contribute to lower BMD z scores in the femur.Low BMD is prevalent in children with moderate to severe CP and is associated with significant fracture risk. The underlying pathophysiology is complex, with multiple factors contributing to the problem and significant variation between different regions of the skeleton." @default.
• W2097582263 created "2016-06-24" @default.
• W2097582263 creator A5025015149 @default.
• W2097582263 creator A5028845015 @default.
• W2097582263 creator A5034626049 @default.
• W2097582263 creator A5037236706 @default.
• W2097582263 creator A5039694997 @default.
• W2097582263 creator A5053513542 @default.
• W2097582263 creator A5070844318 @default.
• W2097582263 creator A5074252032 @default.
• W2097582263 date "2002-07-01" @default.
• W2097582263 modified "2023-10-01" @default.
• W2097582263 title "Bone Density and Metabolism in Children and Adolescents With Moderate to Severe Cerebral Palsy" @default.
• W2097582263 cites W1498550090 @default.
• W2097582263 cites W1829450039 @default.
• W2097582263 cites W1913597598 @default.
• W2097582263 cites W1972587890 @default.
• W2097582263 cites W1979974827 @default.
• W2097582263 cites W1981233402 @default.
• W2097582263 cites W1983860456 @default.
• W2097582263 cites W1983992736 @default.
• W2097582263 cites W1985011707 @default.
• W2097582263 cites W1987768016 @default.
• W2097582263 cites W1995022834 @default.
• W2097582263 cites W2004935947 @default.
• W2097582263 cites W2017165492 @default.
• W2097582263 cites W2021616823 @default.
• W2097582263 cites W2022167001 @default.
• W2097582263 cites W2022373684 @default.
• W2097582263 cites W2028715220 @default.
• W2097582263 cites W2030002143 @default.
• W2097582263 cites W2035475204 @default.
• W2097582263 cites W2046970946 @default.
• W2097582263 cites W2049696804 @default.
• W2097582263 cites W2050098770 @default.
• W2097582263 cites W2052731068 @default.
• W2097582263 cites W2053037324 @default.
• W2097582263 cites W2072626724 @default.
• W2097582263 cites W2076426646 @default.
• W2097582263 cites W2078249213 @default.
• W2097582263 cites W2078612043 @default.
• W2097582263 cites W2079154870 @default.
• W2097582263 cites W2079976633 @default.
• W2097582263 cites W2082269366 @default.
• W2097582263 cites W2125254183 @default.
• W2097582263 cites W2140925434 @default.
• W2097582263 cites W2143666940 @default.
• W2097582263 cites W2155829230 @default.
• W2097582263 cites W2159956582 @default.
• W2097582263 cites W2329575366 @default.
• W2097582263 cites W2967785658 @default.
• W2097582263 cites W42167167 @default.
• W2097582263 cites W4230719493 @default.
• W2097582263 cites W4233650743 @default.
• W2097582263 cites W4233880761 @default.
• W2097582263 cites W4254621294 @default.
• W2097582263 cites W4301306088 @default.
• W2097582263 cites W4318444656 @default.
• W2097582263 doi "https://doi.org/10.1542/peds.110.1.e5" @default.
• W2097582263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12093986" @default.
• W2097582263 hasPublicationYear "2002" @default.
• W2097582263 type Work @default.
• W2097582263 sameAs 2097582263 @default.
• W2097582263 citedByCount "313" @default.
• W2097582263 countsByYear W20975822632012 @default.
• W2097582263 countsByYear W20975822632013 @default.
• W2097582263 countsByYear W20975822632014 @default.
• W2097582263 countsByYear W20975822632015 @default.
• W2097582263 countsByYear W20975822632016 @default.
• W2097582263 countsByYear W20975822632017 @default.
• W2097582263 countsByYear W20975822632018 @default.
• W2097582263 countsByYear W20975822632019 @default.
• W2097582263 countsByYear W20975822632020 @default.
• W2097582263 countsByYear W20975822632021 @default.
• W2097582263 countsByYear W20975822632022 @default.
• W2097582263 countsByYear W20975822632023 @default.
• W2097582263 crossrefType "journal-article" @default.
• W2097582263 hasAuthorship W2097582263A5025015149 @default.
• W2097582263 hasAuthorship W2097582263A5028845015 @default.
• W2097582263 hasAuthorship W2097582263A5034626049 @default.
• W2097582263 hasAuthorship W2097582263A5037236706 @default.
• W2097582263 hasAuthorship W2097582263A5039694997 @default.
• W2097582263 hasAuthorship W2097582263A5053513542 @default.
• W2097582263 hasAuthorship W2097582263A5070844318 @default.
• W2097582263 hasAuthorship W2097582263A5074252032 @default.
• W2097582263 hasBestOaLocation W20975822631 @default.
• W2097582263 hasConcept C119857082 @default.
• W2097582263 hasConcept C126322002 @default.
• W2097582263 hasConcept C141071460 @default.
• W2097582263 hasConcept C1862650 @default.
• W2097582263 hasConcept C187212893 @default.
• W2097582263 hasConcept C20256973 @default.
• W2097582263 hasConcept C2776541429 @default.
• W2097582263 hasConcept C2776886416 @default.
• W2097582263 hasConcept C2777083390 @default.
• W2097582263 hasConcept C2779421357 @default.
• W2097582263 hasConcept C2780554211 @default.
• W2097582263 hasConcept C2908647359 @default.

• next