FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097583406> ?p ?o ?g. }

• W2097583406 endingPage "5492" @default.
• W2097583406 startingPage "5485" @default.
• W2097583406 abstract "ABSTRACT To truly transform the landscape of tuberculosis treatment, novel regimens containing at least 2 new drugs are needed to simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. As part of an ongoing effort to evaluate novel drug combinations for treatment-shortening potential in a murine model, we performed two long-term, relapse-based experiments. In the first experiment, TMC207 plus pyrazinamide, alone or in combination with any third drug, proved superior to the first-line regimen including rifampin, pyrazinamide, and isoniazid. On the basis of CFU counts at 1 month, clofazimine proved to be the best third drug combined with TMC207 and pyrazinamide, whereas the addition of PA-824 was modestly antagonistic. Relapse results were inconclusive due to the low rate of relapse in all test groups. In the second experiment evaluating 3-drug combinations composed of TMC207, pyrazinamide, PA-824, moxifloxacin, and rifapentine, TMC207 plus pyrazinamide plus either rifapentine or moxifloxacin was the most effective, curing 100% and 67% of the mice treated, respectively, in 2 months of treatment. Four months of the first-line regimen did not cure any mice, whereas the combination of TMC207, PA-824, and moxifloxacin cured 50% of the mice treated. The results reveal new building blocks for novel regimens with the potential to shorten the duration of treatment for both drug-susceptible and drug-resistant tuberculosis, including the combination of TMC207, pyrazinamide, PA-824, and a potent fluoroquinolone." @default.
• W2097583406 created "2016-06-24" @default.
• W2097583406 creator A5005701315 @default.
• W2097583406 creator A5041733285 @default.
• W2097583406 creator A5048965341 @default.
• W2097583406 creator A5051024983 @default.
• W2097583406 creator A5055231042 @default.
• W2097583406 creator A5076900297 @default.
• W2097583406 creator A5079086838 @default.
• W2097583406 creator A5082290165 @default.
• W2097583406 date "2011-12-01" @default.
• W2097583406 modified "2023-10-10" @default.
• W2097583406 title "Sterilizing Activity of Novel TMC207- and PA-824-Containing Regimens in a Murine Model of Tuberculosis" @default.
• W2097583406 cites W1867075303 @default.
• W2097583406 cites W1965877207 @default.
• W2097583406 cites W1969586092 @default.
• W2097583406 cites W1974598076 @default.
• W2097583406 cites W1980215098 @default.
• W2097583406 cites W2000241568 @default.
• W2097583406 cites W2008952784 @default.
• W2097583406 cites W2013159525 @default.
• W2097583406 cites W2026701298 @default.
• W2097583406 cites W2047701762 @default.
• W2097583406 cites W2068022493 @default.
• W2097583406 cites W2069392205 @default.
• W2097583406 cites W2084062265 @default.
• W2097583406 cites W2096403772 @default.
• W2097583406 cites W2098793988 @default.
• W2097583406 cites W2109725458 @default.
• W2097583406 cites W2118359175 @default.
• W2097583406 cites W2120833699 @default.
• W2097583406 cites W2125547281 @default.
• W2097583406 cites W2133587820 @default.
• W2097583406 cites W2134476763 @default.
• W2097583406 cites W2139012536 @default.
• W2097583406 cites W2145316521 @default.
• W2097583406 cites W2158379954 @default.
• W2097583406 cites W2158530209 @default.
• W2097583406 cites W2158658436 @default.
• W2097583406 cites W2159830610 @default.
• W2097583406 cites W2160434710 @default.
• W2097583406 cites W2161340676 @default.
• W2097583406 cites W2164282552 @default.
• W2097583406 cites W2167163155 @default.
• W2097583406 cites W2169800706 @default.
• W2097583406 cites W2171796124 @default.
• W2097583406 doi "https://doi.org/10.1128/aac.05293-11" @default.
• W2097583406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3232786" @default.
• W2097583406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21930883" @default.
• W2097583406 hasPublicationYear "2011" @default.
• W2097583406 type Work @default.
• W2097583406 sameAs 2097583406 @default.
• W2097583406 citedByCount "169" @default.
• W2097583406 countsByYear W20975834062012 @default.
• W2097583406 countsByYear W20975834062013 @default.
• W2097583406 countsByYear W20975834062014 @default.
• W2097583406 countsByYear W20975834062015 @default.
• W2097583406 countsByYear W20975834062016 @default.
• W2097583406 countsByYear W20975834062017 @default.
• W2097583406 countsByYear W20975834062018 @default.
• W2097583406 countsByYear W20975834062019 @default.
• W2097583406 countsByYear W20975834062020 @default.
• W2097583406 countsByYear W20975834062021 @default.
• W2097583406 countsByYear W20975834062022 @default.
• W2097583406 countsByYear W20975834062023 @default.
• W2097583406 crossrefType "journal-article" @default.
• W2097583406 hasAuthorship W2097583406A5005701315 @default.
• W2097583406 hasAuthorship W2097583406A5041733285 @default.
• W2097583406 hasAuthorship W2097583406A5048965341 @default.
• W2097583406 hasAuthorship W2097583406A5051024983 @default.
• W2097583406 hasAuthorship W2097583406A5055231042 @default.
• W2097583406 hasAuthorship W2097583406A5076900297 @default.
• W2097583406 hasAuthorship W2097583406A5079086838 @default.
• W2097583406 hasAuthorship W2097583406A5082290165 @default.
• W2097583406 hasBestOaLocation W20975834061 @default.
• W2097583406 hasConcept C126322002 @default.
• W2097583406 hasConcept C142724271 @default.
• W2097583406 hasConcept C203014093 @default.
• W2097583406 hasConcept C2776297342 @default.
• W2097583406 hasConcept C2776967927 @default.
• W2097583406 hasConcept C2776991065 @default.
• W2097583406 hasConcept C2777975735 @default.
• W2097583406 hasConcept C2778836808 @default.
• W2097583406 hasConcept C2779806340 @default.
• W2097583406 hasConcept C2780035454 @default.
• W2097583406 hasConcept C2780459521 @default.
• W2097583406 hasConcept C2780695269 @default.
• W2097583406 hasConcept C2781069245 @default.
• W2097583406 hasConcept C2781413609 @default.
• W2097583406 hasConcept C501593827 @default.
• W2097583406 hasConcept C71924100 @default.
• W2097583406 hasConcept C86803240 @default.
• W2097583406 hasConcept C89423630 @default.
• W2097583406 hasConcept C98274493 @default.
• W2097583406 hasConceptScore W2097583406C126322002 @default.
• W2097583406 hasConceptScore W2097583406C142724271 @default.
• W2097583406 hasConceptScore W2097583406C203014093 @default.
• W2097583406 hasConceptScore W2097583406C2776297342 @default.

• next