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- W2097591929 abstract "Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen. The mechanism underlying B cell selection has not yet been defined. By employing an agent-based model, we show that for physiologically reasonable parameter values affinity maturation can be driven by competition for neither binding sites nor antigen—even in the presence of competing secreted antibodies. Within the tested mechanisms, only clonal competition for T cell help or a refractory time for the interaction of centrocytes with follicular dendritic cells is found to enable affinity maturation while generating the experimentally observed germinal centre characteristics and tolerating large variations in the initial antigen density." @default.
- W2097591929 created "2016-06-24" @default.
- W2097591929 creator A5000913635 @default.
- W2097591929 creator A5024162635 @default.
- W2097591929 creator A5025791169 @default.
- W2097591929 date "2006-09-01" @default.
- W2097591929 modified "2023-10-17" @default.
- W2097591929 title "An analysis of B cell selection mechanisms in germinal centers" @default.
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- W2097591929 doi "https://doi.org/10.1093/imammb/dql012" @default.
- W2097591929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16707510" @default.
- W2097591929 hasPublicationYear "2006" @default.
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