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• W2097594583 abstract "Summary Although persons with hepatitis C virus ( HCV ) infection may experience nonhepatic illnesses, little is known about the frequency of and trends in such conditions in a population‐based sample of HCV ‐infected persons. Using hospitalization data collected during 2004–2011 from the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project, we examined trends in comorbidities among all hospitalizations that included either a principal or secondary HCV diagnostic code (i.e., HCV was not necessarily the cause for hospitalization). We also compared comorbidities among all persons aged 45–64 years hospitalized with and without principal or secondary HCV diagnostic codes. The estimated number of hospitalizations among persons with HCV infection increased from 850 490 in 2004–2005 to 1 178 633 in 2010–2011; mean age at hospitalization was 50 years in 2004–2005 and 52.5 years in 2010–2011. There were significant increases in the prevalence of most medical and psychiatric comorbidities; the largest were for lipid disorders, chronic kidney disease and obesity. Among HCV ‐infected aged 45–64 persons hospitalized for any cause, the prevalence of alcohol /substance abuse, mental disorders, chronic kidney disease, pneumonia, hepatitis B virus infection and HIV infection were significantly higher than those aged 45–64 persons hospitalized without HCV infection ( P < 0.001 for all). The prevalence of cryoglobulinaemia, vasculitis, nephrotic syndrome or membranoproliferative glomerulonephritis and porphyria cutanea tarda among hospitalizations with HCV infection was consistently low during the study period (i.e., <0.5%). The increase we observed in nonhepatic comorbidities associated with a high risk of HCV ‐related complications has important implications for the current HCV treatment recommendations in a greatly expanded treatment population." @default.
• W2097594583 created "2016-06-24" @default.
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• W2097594583 date "2015-04-20" @default.
• W2097594583 modified "2023-10-03" @default.
• W2097594583 title "Increase in nonhepatic diagnoses among persons with hepatitis C hospitalized for any cause, United States, 2004-2011" @default.
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• W2097594583 doi "https://doi.org/10.1111/jvh.12414" @default.
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