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- W2097595407 abstract "Starting from the (C57BL/6 x DBA/2)F1 generation (Fv-2s/Fv-2r), 16 serial backcrosses to mice of the parental DBA/2 strain (Fv-2s/Fv-2s) were bred. In each generation, heterozygous Fv-2s/Fv-2r segregants were selected and backcrossed with a DBA/2 parent. In the 16th generation, Fv-2s/Fv-2r heterozygotes were intercrossed, and Fv-2r/Fv-2r homozygotes were selected for interbreeding to establish a congenic strain, D2.B6-Fv-2r. The successful establishment of this congenic strain is in contrast with previous findings suggesting that homozygosity for the Fv-2r allele might be a lethal genotype on the DBA/2 genetic background. At least 10 centimorgans of Fv-2r-linked chromosomal material originating from the C57BL/6 ancestor remains in the D2.B6-Fv-2r genome, as shown by the continued presence of C57BL/6 alleles at the flanking Kfo-1 and Bgl-s loci. The observed recombination frequency for the intervals between Fv-2 and Bgl-s was 6.8%." @default.
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- W2097595407 date "1981-04-01" @default.
- W2097595407 modified "2023-09-27" @default.
- W2097595407 title "Construction of a D2.B6-Fv-2<sup>r</sup> Congenic Mouse Strain: Nonlethality of the Homozygous <italic>Fv-2<sup>r</sup></italic> Genotype<xref ref-type=fn rid=fn2>2</xref><xref ref-type=fn rid=fn3>3</xref>" @default.
- W2097595407 doi "https://doi.org/10.1093/jnci/66.4.755" @default.
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- W2097595407 hasPublicationYear "1981" @default.
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