FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097601524> ?p ?o ?g. }

• W2097601524 endingPage "6919" @default.
• W2097601524 startingPage "6908" @default.
• W2097601524 abstract "Cajal-Retzius (CR) cells are among the earliest generated neurons and are thought to play a role in corticogenesis and early neuronal migration. However, the role of CR cells in an early cortical microcircuit is still rather unclear. We therefore have investigated the morphology and physiology of CR cells by using whole-cell patch-clamp recordings combined with intracellular biocytin filling in acute brain slices of postnatal day 5-11 rats. CR cells are characterized by a long horizontally oriented dendrite; the axonal collaterals form a dense horizontally oriented plexus in layer 1 and to a certain extent in layer 2/3, projecting over >2 mm of cortical surface. The bouton density is relatively high, and synaptic contacts are established preferentially with dendritic spines or shafts of excitatory neurons, presumably terminal tuft dendrites of pyramidal neurons. In turn, CR cells receive dense GABAergic and non-GABAergic input on somata, dendritic shafts, and spine-like appendages. Extracellular stimulation in layer 1 could activate both GABAergic and glutamatergic synaptic inputs. The GABAergic response was blocked by the GABA(A) receptor antagonist bicuculline. The glutamatergic response was mediated solely by NMDA receptors and was highly sensitive to ifenprodil, indicating that it was mediated mainly via NR1/NR2B subunit-containing receptors. NMDA EPSPs were apparent in 1 mm extracellular Mg2+, suggesting that this pure NMDA synapse is not silent functionally. Together, the long-range horizontal projection of the axon, the high density of synaptic boutons, and the functional synaptic input of CR cells suggest that they are an integral part of an early cortical network." @default.
• W2097601524 created "2016-06-24" @default.
• W2097601524 creator A5011089938 @default.
• W2097601524 creator A5058150215 @default.
• W2097601524 creator A5080419024 @default.
• W2097601524 date "2002-08-15" @default.
• W2097601524 modified "2023-10-18" @default.
• W2097601524 title "Axonal Projection, Input and Output Synapses, and Synaptic Physiology of Cajal–Retzius Cells in the Developing Rat Neocortex" @default.
• W2097601524 cites W1489264149 @default.
• W2097601524 cites W1503727145 @default.
• W2097601524 cites W1534190696 @default.
• W2097601524 cites W1539130630 @default.
• W2097601524 cites W1575251487 @default.
• W2097601524 cites W1605336512 @default.
• W2097601524 cites W1643765411 @default.
• W2097601524 cites W1648161123 @default.
• W2097601524 cites W1682302400 @default.
• W2097601524 cites W1705218924 @default.
• W2097601524 cites W1749817144 @default.
• W2097601524 cites W1796084599 @default.
• W2097601524 cites W1821468701 @default.
• W2097601524 cites W1856380311 @default.
• W2097601524 cites W1898334791 @default.
• W2097601524 cites W1968028177 @default.
• W2097601524 cites W1975939971 @default.
• W2097601524 cites W1978641918 @default.
• W2097601524 cites W1979890518 @default.
• W2097601524 cites W1989505091 @default.
• W2097601524 cites W1997352195 @default.
• W2097601524 cites W2002287054 @default.
• W2097601524 cites W2004840809 @default.
• W2097601524 cites W2014962164 @default.
• W2097601524 cites W2026077224 @default.
• W2097601524 cites W2033604856 @default.
• W2097601524 cites W2035017467 @default.
• W2097601524 cites W2036021978 @default.
• W2097601524 cites W2038748595 @default.
• W2097601524 cites W2041024256 @default.
• W2097601524 cites W2046663536 @default.
• W2097601524 cites W2051378734 @default.
• W2097601524 cites W2054196099 @default.
• W2097601524 cites W2063367097 @default.
• W2097601524 cites W2065169750 @default.
• W2097601524 cites W2065327768 @default.
• W2097601524 cites W2065848862 @default.
• W2097601524 cites W2066963710 @default.
• W2097601524 cites W2070651871 @default.
• W2097601524 cites W2071684215 @default.
• W2097601524 cites W2081669905 @default.
• W2097601524 cites W2083659928 @default.
• W2097601524 cites W2085287004 @default.
• W2097601524 cites W2087538693 @default.
• W2097601524 cites W2087849583 @default.
• W2097601524 cites W2088693403 @default.
• W2097601524 cites W2094515022 @default.
• W2097601524 cites W2104491845 @default.
• W2097601524 cites W2105874268 @default.
• W2097601524 cites W2106414999 @default.
• W2097601524 cites W2108488022 @default.
• W2097601524 cites W2110411315 @default.
• W2097601524 cites W2115201577 @default.
• W2097601524 cites W2116491807 @default.
• W2097601524 cites W2121239869 @default.
• W2097601524 cites W2121621082 @default.
• W2097601524 cites W2127025004 @default.
• W2097601524 cites W2127086782 @default.
• W2097601524 cites W2148478579 @default.
• W2097601524 cites W2152487533 @default.
• W2097601524 cites W2158486426 @default.
• W2097601524 cites W2160274383 @default.
• W2097601524 cites W2160570864 @default.
• W2097601524 cites W2163708115 @default.
• W2097601524 cites W2169905512 @default.
• W2097601524 cites W2171370311 @default.
• W2097601524 cites W2171767741 @default.
• W2097601524 cites W2410633447 @default.
• W2097601524 cites W2415849001 @default.
• W2097601524 cites W4251401827 @default.
• W2097601524 doi "https://doi.org/10.1523/jneurosci.22-16-06908.2002" @default.
• W2097601524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757901" @default.
• W2097601524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12177189" @default.
• W2097601524 hasPublicationYear "2002" @default.
• W2097601524 type Work @default.
• W2097601524 sameAs 2097601524 @default.
• W2097601524 citedByCount "88" @default.
• W2097601524 countsByYear W20976015242012 @default.
• W2097601524 countsByYear W20976015242013 @default.
• W2097601524 countsByYear W20976015242014 @default.
• W2097601524 countsByYear W20976015242015 @default.
• W2097601524 countsByYear W20976015242016 @default.
• W2097601524 countsByYear W20976015242017 @default.
• W2097601524 countsByYear W20976015242018 @default.
• W2097601524 countsByYear W20976015242019 @default.
• W2097601524 countsByYear W20976015242020 @default.
• W2097601524 countsByYear W20976015242021 @default.
• W2097601524 countsByYear W20976015242023 @default.
• W2097601524 crossrefType "journal-article" @default.
• W2097601524 hasAuthorship W2097601524A5011089938 @default.

• next