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- W2097611199 abstract "Transient receptor potential melastatin 3 (TRPM3) channels are non-selective cation channels that are expressed in insulinoma cells and pancreatic β-cells. Stimulation of TRPM3 with the neurosteroid pregnenolone sulfate induces an intracellular signaling cascade, involving a rise in intracellular Ca 2 + concentration, activation of the protein kinases Raf and ERK, and a change in the gene expression pattern of the cells. In particular, biosynthesis of insulin is altered following activation of TRPM3 by pregnenolone sulfate. Moreover, a direct effect of TRPM3 stimulation on insulin secretion has been reported. The fact that stimulation of TRPM3 induces a signaling cascade that is very similar to the signaling cascade induced by glucose in β-cells suggests that TRPM3 may influence main functions of pancreatic β-cells. The view that TRPM3 represents an ionotropic steroid receptor of pancreatic β-cells linking insulin release with steroid hormone signaling is discussed." @default.
- W2097611199 created "2016-06-24" @default.
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- W2097611199 date "2013-03-19" @default.
- W2097611199 modified "2023-10-14" @default.
- W2097611199 title "Signal transduction via TRPM3 channels in pancreatic β-cells" @default.
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- W2097611199 doi "https://doi.org/10.1530/jme-12-0237" @default.
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