FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097614312> ?p ?o ?g. }

• W2097614312 endingPage "605" @default.
• W2097614312 startingPage "596" @default.
• W2097614312 abstract "The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clear. By gel shift assay, we showed that mutant p53S had lost its DNA binding ability to its target promoters. Further real-time PCR data confirmed that p53S had lost the function of regulating the transcription of p21( Cip1/Waf1), cyclin G, PUMA, and Bax in response to 10Gy irradiation. These data confirmed the loss of function of p53S in mammalian cells. By xenograft assay, we showed that the p53S per se was not oncogenic enough to form tumor, however, cooperating with H-RasV12, p53S could dramatically promote tumorigenesis in p53 null MEFs. Further study showed that co-expression of p53S and H-RasV12 could increase the expression level of H-RasV12 and partially eliminate the elevation of stress response proteins such as Chk2, γ-H2AX, Hsp70, Rb, p16(Ink4a) caused by either p53S or H-RasV12. These data suggested that p53S cross-talked with H-RasV12 and reduced the cellular stress response to oncogenic signals, which facilitated the cell growth and tumorigenesis. Together these data provided the molecular basis for the cooperation of p53S and H-RasV12 and revealed the gain of function of p53S in cross-talking with H-RasV12. This study revealed an important aspect of gain of function for p53 mutant, therefore might shed light on the clinical strategy in targeting p53 mutant." @default.
• W2097614312 created "2016-06-24" @default.
• W2097614312 creator A5017995140 @default.
• W2097614312 creator A5028564969 @default.
• W2097614312 creator A5040046800 @default.
• W2097614312 creator A5061994033 @default.
• W2097614312 date "2012-01-01" @default.
• W2097614312 modified "2023-10-01" @default.
• W2097614312 title "The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12" @default.
• W2097614312 cites W1968075505 @default.
• W2097614312 cites W1970037245 @default.
• W2097614312 cites W1972450713 @default.
• W2097614312 cites W1986076152 @default.
• W2097614312 cites W1990508187 @default.
• W2097614312 cites W1992995822 @default.
• W2097614312 cites W1994015824 @default.
• W2097614312 cites W2005914574 @default.
• W2097614312 cites W2018614123 @default.
• W2097614312 cites W2020546422 @default.
• W2097614312 cites W2024143289 @default.
• W2097614312 cites W2032253601 @default.
• W2097614312 cites W2033512218 @default.
• W2097614312 cites W2034227568 @default.
• W2097614312 cites W2040673957 @default.
• W2097614312 cites W2062202414 @default.
• W2097614312 cites W2072052957 @default.
• W2097614312 cites W2079972365 @default.
• W2097614312 cites W2087404852 @default.
• W2097614312 cites W2088740611 @default.
• W2097614312 cites W2089289562 @default.
• W2097614312 cites W2089805984 @default.
• W2097614312 cites W2090291378 @default.
• W2097614312 cites W2094427247 @default.
• W2097614312 cites W2110761051 @default.
• W2097614312 cites W2121371748 @default.
• W2097614312 cites W2132399579 @default.
• W2097614312 cites W2137023032 @default.
• W2097614312 cites W2158155127 @default.
• W2097614312 cites W2161659436 @default.
• W2097614312 cites W2169326511 @default.
• W2097614312 cites W2187031962 @default.
• W2097614312 cites W2325557141 @default.
• W2097614312 cites W2388163742 @default.
• W2097614312 cites W2418472113 @default.
• W2097614312 doi "https://doi.org/10.7150/ijbs.4176" @default.
• W2097614312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3341601" @default.
• W2097614312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22553460" @default.
• W2097614312 hasPublicationYear "2012" @default.
• W2097614312 type Work @default.
• W2097614312 sameAs 2097614312 @default.
• W2097614312 citedByCount "17" @default.
• W2097614312 countsByYear W20976143122012 @default.
• W2097614312 countsByYear W20976143122013 @default.
• W2097614312 countsByYear W20976143122014 @default.
• W2097614312 countsByYear W20976143122017 @default.
• W2097614312 countsByYear W20976143122018 @default.
• W2097614312 countsByYear W20976143122019 @default.
• W2097614312 countsByYear W20976143122020 @default.
• W2097614312 countsByYear W20976143122021 @default.
• W2097614312 countsByYear W20976143122022 @default.
• W2097614312 countsByYear W20976143122023 @default.
• W2097614312 crossrefType "journal-article" @default.
• W2097614312 hasAuthorship W2097614312A5017995140 @default.
• W2097614312 hasAuthorship W2097614312A5028564969 @default.
• W2097614312 hasAuthorship W2097614312A5040046800 @default.
• W2097614312 hasAuthorship W2097614312A5061994033 @default.
• W2097614312 hasBestOaLocation W20976143121 @default.
• W2097614312 hasConcept C104317684 @default.
• W2097614312 hasConcept C105951970 @default.
• W2097614312 hasConcept C121608353 @default.
• W2097614312 hasConcept C127716648 @default.
• W2097614312 hasConcept C143065580 @default.
• W2097614312 hasConcept C143425029 @default.
• W2097614312 hasConcept C153911025 @default.
• W2097614312 hasConcept C185592680 @default.
• W2097614312 hasConcept C207583985 @default.
• W2097614312 hasConcept C3020204279 @default.
• W2097614312 hasConcept C502942594 @default.
• W2097614312 hasConcept C54355233 @default.
• W2097614312 hasConcept C552990157 @default.
• W2097614312 hasConcept C555283112 @default.
• W2097614312 hasConcept C86803240 @default.
• W2097614312 hasConcept C95444343 @default.
• W2097614312 hasConceptScore W2097614312C104317684 @default.
• W2097614312 hasConceptScore W2097614312C105951970 @default.
• W2097614312 hasConceptScore W2097614312C121608353 @default.
• W2097614312 hasConceptScore W2097614312C127716648 @default.
• W2097614312 hasConceptScore W2097614312C143065580 @default.
• W2097614312 hasConceptScore W2097614312C143425029 @default.
• W2097614312 hasConceptScore W2097614312C153911025 @default.
• W2097614312 hasConceptScore W2097614312C185592680 @default.
• W2097614312 hasConceptScore W2097614312C207583985 @default.
• W2097614312 hasConceptScore W2097614312C3020204279 @default.
• W2097614312 hasConceptScore W2097614312C502942594 @default.
• W2097614312 hasConceptScore W2097614312C54355233 @default.
• W2097614312 hasConceptScore W2097614312C552990157 @default.
• W2097614312 hasConceptScore W2097614312C555283112 @default.
• W2097614312 hasConceptScore W2097614312C86803240 @default.

• next