FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097614332> ?p ?o ?g. }

• W2097614332 endingPage "144" @default.
• W2097614332 startingPage "138" @default.
• W2097614332 abstract "The underlying mechanism for the biological activity of inorganic mercury is believed to be the high affinity binding of divalent mercuric cations to thiols of sulfhydryl groups of proteins. A comprehensive analysis of published data indicates that inorganic mercury is one of the most environmentally abundant toxic metals, is a potent and selective nephrotoxicant that preferentially accumulates in the kidneys, and is known to produce cellular injury in the kidneys. Binding sites are present in the proximal tubules, and it is in the epithelial cells of these tubules that toxicants such as inorganic mercury are reabsorbed. This can affect the enzymatic activity and the structure of various proteins. Mercury may alter protein and membrane structure and function in the epithelial cells and this alteration may result in long term residual effects. This research was therefore designed to evaluate the dose-response relationship in human renal proximal tubule (HK-2) cells following exposure to inorganic mercury. Cytotoxicity was evaluated using the MTT assay for cell viability. The Annexin-V assay was performed by flow cytometry to determine the extent of phosphatidylserine externalization. Cells were exposed to mercury for 24 hours at doses of 0, 1, 2, 3, 4, 5, and 6 microg/mL. Cytotoxicity experiments yielded a LD50 value of 4.65 +/- 0.6 microg/mL indicating that mercury is highly toxic. The percentages of cells undergoing early apoptosis were 0.70 +/- 0.03%, 10.0 +/- 0.02%, 11.70 +/- 0.03%, 15.20 +/- 0.02%, 16.70 +/- 0.03%, 24.20 +/-0.02%, and 25.60 +/- 0.04% at treatments of 0, 1, 2, 3, 4, 5, and 6 microg/mL of mercury respectively. This indicates a dose-response relationship with regard to mercury-induced cytotoxicity and the externalization of phosphatidylserine in HK-2 cells." @default.
• W2097614332 created "2016-06-24" @default.
• W2097614332 creator A5020984178 @default.
• W2097614332 creator A5034293857 @default.
• W2097614332 date "2007-06-30" @default.
• W2097614332 modified "2023-09-27" @default.
• W2097614332 title "Mercury Induces the Externalization of Phosphatidyl-Serine in Human Renal Proximal Tubule (HK-2) Cells" @default.
• W2097614332 cites W1557443776 @default.
• W2097614332 cites W1571529930 @default.
• W2097614332 cites W1779061316 @default.
• W2097614332 cites W18369313 @default.
• W2097614332 cites W1843827618 @default.
• W2097614332 cites W1936780801 @default.
• W2097614332 cites W1971010052 @default.
• W2097614332 cites W1985868156 @default.
• W2097614332 cites W1988838635 @default.
• W2097614332 cites W2008030104 @default.
• W2097614332 cites W2018077387 @default.
• W2097614332 cites W2024980625 @default.
• W2097614332 cites W2030475813 @default.
• W2097614332 cites W2031604884 @default.
• W2097614332 cites W2032849280 @default.
• W2097614332 cites W2036937264 @default.
• W2097614332 cites W2043116981 @default.
• W2097614332 cites W2043282593 @default.
• W2097614332 cites W2045751236 @default.
• W2097614332 cites W2051339469 @default.
• W2097614332 cites W2055207258 @default.
• W2097614332 cites W2058170418 @default.
• W2097614332 cites W2067668021 @default.
• W2097614332 cites W2071570745 @default.
• W2097614332 cites W2071806271 @default.
• W2097614332 cites W2072274986 @default.
• W2097614332 cites W2072698473 @default.
• W2097614332 cites W2072944844 @default.
• W2097614332 cites W2075893848 @default.
• W2097614332 cites W2078241781 @default.
• W2097614332 cites W2085717910 @default.
• W2097614332 cites W2090900055 @default.
• W2097614332 cites W2103816330 @default.
• W2097614332 cites W2119685625 @default.
• W2097614332 cites W2121895685 @default.
• W2097614332 cites W2125005268 @default.
• W2097614332 cites W2126751746 @default.
• W2097614332 cites W2127390652 @default.
• W2097614332 cites W2133790238 @default.
• W2097614332 cites W2150563383 @default.
• W2097614332 cites W2154186851 @default.
• W2097614332 cites W2161690037 @default.
• W2097614332 cites W2167855995 @default.
• W2097614332 cites W2170415938 @default.
• W2097614332 cites W2256057330 @default.
• W2097614332 cites W2266714865 @default.
• W2097614332 cites W2162599735 @default.
• W2097614332 doi "https://doi.org/10.3390/ijerph2007040008" @default.
• W2097614332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3728579" @default.
• W2097614332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17617677" @default.
• W2097614332 hasPublicationYear "2007" @default.
• W2097614332 type Work @default.
• W2097614332 sameAs 2097614332 @default.
• W2097614332 citedByCount "30" @default.
• W2097614332 countsByYear W20976143322012 @default.
• W2097614332 countsByYear W20976143322013 @default.
• W2097614332 countsByYear W20976143322014 @default.
• W2097614332 countsByYear W20976143322015 @default.
• W2097614332 countsByYear W20976143322016 @default.
• W2097614332 countsByYear W20976143322017 @default.
• W2097614332 countsByYear W20976143322018 @default.
• W2097614332 countsByYear W20976143322019 @default.
• W2097614332 countsByYear W20976143322020 @default.
• W2097614332 countsByYear W20976143322021 @default.
• W2097614332 countsByYear W20976143322022 @default.
• W2097614332 countsByYear W20976143322023 @default.
• W2097614332 crossrefType "journal-article" @default.
• W2097614332 hasAuthorship W2097614332A5020984178 @default.
• W2097614332 hasAuthorship W2097614332A5034293857 @default.
• W2097614332 hasBestOaLocation W20976143321 @default.
• W2097614332 hasConcept C109316439 @default.
• W2097614332 hasConcept C134018914 @default.
• W2097614332 hasConcept C153911025 @default.
• W2097614332 hasConcept C178790620 @default.
• W2097614332 hasConcept C185592680 @default.
• W2097614332 hasConcept C190283241 @default.
• W2097614332 hasConcept C199360897 @default.
• W2097614332 hasConcept C202751555 @default.
• W2097614332 hasConcept C2777777548 @default.
• W2097614332 hasConcept C2778918659 @default.
• W2097614332 hasConcept C2779637612 @default.
• W2097614332 hasConcept C2780091579 @default.
• W2097614332 hasConcept C2780783641 @default.
• W2097614332 hasConcept C41008148 @default.
• W2097614332 hasConcept C41625074 @default.
• W2097614332 hasConcept C553184892 @default.
• W2097614332 hasConcept C55493867 @default.
• W2097614332 hasConcept C74884574 @default.
• W2097614332 hasConcept C86803240 @default.
• W2097614332 hasConcept C88634738 @default.
• W2097614332 hasConceptScore W2097614332C109316439 @default.

• next