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• W2097615937 abstract "ABSTRACT Epstein-Barr virus nuclear antigen 2 (EBNA2) is essential for B-cell immortalization by EBV, most probably by its ability to transactivate a number of cellular and viral genes. EBNA2-responsive elements (EBNA2REs) have been identified in several EBNA2-regulated viral promoters, each of them carrying at least one RBP-Jκ recognition site. RBP-Jκ recruits EBNA2 to the EBNA2RE and, once complexed to EBNA2, is converted from a repressor into an activator. An activated form of the cellular receptor Notch also interacts with RBP-Jκ, providing a link between EBNA2 and Notch signalling. To determine whether activated Notch is able to transactivate EBNA2-responsive viral promoters, we performed cotransfection experiments with activated mouse Notch1 (mNotch1-IC) and luciferase constructs of the Bam HI C, LMP1, and LMP2A promoters. We present here evidence that mNotch1-IC transactivates viral promoters known to be regulated by EBNA2. As shown for EBNA2, mutations or deletions of the RBP-Jκ sites diminish or eliminate mNotch1-IC-mediated transactivation of the promoters, pointing to an essential role for Notch–RBP-Jκ interaction. In addition to RBP-Jκ, other cellular factors may bind within the EBNA2REs of viral promoters. While some factors appear to play an important role in both EBNA2- and mNotch1-IC-mediated transactivation, others are only important for the activity of either EBNA2 or mNotch1-IC. We could observe specific mNotch1-IC-responsive regions, thereby throwing more light upon which cofactors interact with EBNA2 and mNotch1-IC, thus enabling them to become functionally transactivators in vivo." @default.
• W2097615937 created "2016-06-24" @default.
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• W2097615937 date "1999-04-01" @default.
• W2097615937 modified "2023-10-17" @default.
• W2097615937 title "Activated Mouse Notch1 Transactivates Epstein-Barr Virus Nuclear Antigen 2-Regulated Viral Promoters" @default.
• W2097615937 cites W1510154907 @default.
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• W2097615937 cites W1532822341 @default.
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• W2097615937 cites W1550709242 @default.
• W2097615937 cites W1558516755 @default.
• W2097615937 cites W1600425139 @default.
• W2097615937 cites W1611999423 @default.
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• W2097615937 cites W1965007686 @default.
• W2097615937 cites W1970269101 @default.
• W2097615937 cites W1980464074 @default.
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• W2097615937 cites W1993243592 @default.
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• W2097615937 cites W2000550532 @default.
• W2097615937 cites W2009561614 @default.
• W2097615937 cites W2018316546 @default.
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• W2097615937 cites W2062084323 @default.
• W2097615937 cites W2076277896 @default.
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• W2097615937 doi "https://doi.org/10.1128/jvi.73.4.2770-2780.1999" @default.
• W2097615937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104034" @default.
• W2097615937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10074124" @default.
• W2097615937 hasPublicationYear "1999" @default.
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