FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097621976> ?p ?o ?g. }

• W2097621976 endingPage "208" @default.
• W2097621976 startingPage "204" @default.
• W2097621976 abstract "<h3>Background</h3> Conditions characterised by chronic visceral pain represent a significant healthcare burden with limited treatment options. While animal models have provided insights into potential mechanisms of visceral nociception and identified candidate drug targets, these have not translated into successful treatments in humans. <h3>Objective</h3> To develop an in vitro afferent nerve preparation using surgically excised freshly isolated human colon and vermiform appendix-mesentery tissues. <h3>Methods</h3> Non-inflamed appendix (n=18) and colon (n=9) were collected from patients undergoing right and left hemicolectomy. Electrophysiological recordings were made from mesenteric nerves and the tissue stimulated chemically and mechanically. <h3>Results</h3> Ongoing neuronal activity was sparse and where units occurred peak firing rates were: colon (2.0±0.4 spikes/s, n=4) and appendix (2.4±0.6 spikes/s, n=9). Afferent nerves innervating the appendix responded with a significant increase in activity following stimulation with inflammatory mediators (73±10.6 vs 3.0±0.3 spikes/s, n=6, p<0.001, inflammatory mediator vs baseline) and capsaicin (63±15.8 vs 2±0.3 spikes/s, n=3, p<0.001, capsaicin vs buffer). Afferent nerves innervating the colon responded with increased activity to blunt probing of the serosal surface. <h3>Conclusions</h3> This first-in-human study demonstrates afferent nerve recordings from human gut tissue ex vivo and shows that tissue may be stimulated both chemically and mechanically to study neuronal responses. Collectively, the results provide preliminary evidence to validate this in vitro human tissue model as one that may aid future disease mechanistic studies and candidate drug testing." @default.
• W2097621976 created "2016-06-24" @default.
• W2097621976 creator A5002945055 @default.
• W2097621976 creator A5019815080 @default.
• W2097621976 creator A5026678415 @default.
• W2097621976 creator A5038464425 @default.
• W2097621976 creator A5046012946 @default.
• W2097621976 creator A5054250912 @default.
• W2097621976 creator A5062693472 @default.
• W2097621976 creator A5068102799 @default.
• W2097621976 creator A5081517389 @default.
• W2097621976 date "2010-10-28" @default.
• W2097621976 modified "2023-09-27" @default.
• W2097621976 title "Human visceral afferent recordings: preliminary report" @default.
• W2097621976 cites W1511198581 @default.
• W2097621976 cites W1982281847 @default.
• W2097621976 cites W1984851516 @default.
• W2097621976 cites W1985391042 @default.
• W2097621976 cites W1988842352 @default.
• W2097621976 cites W1991757527 @default.
• W2097621976 cites W1992757539 @default.
• W2097621976 cites W1999119820 @default.
• W2097621976 cites W2003196086 @default.
• W2097621976 cites W2012262589 @default.
• W2097621976 cites W2025538956 @default.
• W2097621976 cites W2046687620 @default.
• W2097621976 cites W2087082823 @default.
• W2097621976 cites W2090012397 @default.
• W2097621976 cites W2105445407 @default.
• W2097621976 cites W2111168039 @default.
• W2097621976 cites W2113426565 @default.
• W2097621976 cites W2122526508 @default.
• W2097621976 cites W2140528350 @default.
• W2097621976 cites W2143620984 @default.
• W2097621976 cites W2151257438 @default.
• W2097621976 cites W2153948250 @default.
• W2097621976 cites W2156059840 @default.
• W2097621976 cites W2156286274 @default.
• W2097621976 cites W2162196711 @default.
• W2097621976 cites W2323683381 @default.
• W2097621976 cites W2058379850 @default.
• W2097621976 doi "https://doi.org/10.1136/gut.2010.221820" @default.
• W2097621976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21030526" @default.
• W2097621976 hasPublicationYear "2010" @default.
• W2097621976 type Work @default.
• W2097621976 sameAs 2097621976 @default.
• W2097621976 citedByCount "48" @default.
• W2097621976 countsByYear W20976219762012 @default.
• W2097621976 countsByYear W20976219762013 @default.
• W2097621976 countsByYear W20976219762014 @default.
• W2097621976 countsByYear W20976219762015 @default.
• W2097621976 countsByYear W20976219762016 @default.
• W2097621976 countsByYear W20976219762017 @default.
• W2097621976 countsByYear W20976219762018 @default.
• W2097621976 countsByYear W20976219762019 @default.
• W2097621976 countsByYear W20976219762020 @default.
• W2097621976 countsByYear W20976219762021 @default.
• W2097621976 countsByYear W20976219762023 @default.
• W2097621976 crossrefType "journal-article" @default.
• W2097621976 hasAuthorship W2097621976A5002945055 @default.
• W2097621976 hasAuthorship W2097621976A5019815080 @default.
• W2097621976 hasAuthorship W2097621976A5026678415 @default.
• W2097621976 hasAuthorship W2097621976A5038464425 @default.
• W2097621976 hasAuthorship W2097621976A5046012946 @default.
• W2097621976 hasAuthorship W2097621976A5054250912 @default.
• W2097621976 hasAuthorship W2097621976A5062693472 @default.
• W2097621976 hasAuthorship W2097621976A5068102799 @default.
• W2097621976 hasAuthorship W2097621976A5081517389 @default.
• W2097621976 hasConcept C126322002 @default.
• W2097621976 hasConcept C150903083 @default.
• W2097621976 hasConcept C15490471 @default.
• W2097621976 hasConcept C170493617 @default.
• W2097621976 hasConcept C185263204 @default.
• W2097621976 hasConcept C201539569 @default.
• W2097621976 hasConcept C204232928 @default.
• W2097621976 hasConcept C207001950 @default.
• W2097621976 hasConcept C24998067 @default.
• W2097621976 hasConcept C26291073 @default.
• W2097621976 hasConcept C2779263132 @default.
• W2097621976 hasConcept C2779794527 @default.
• W2097621976 hasConcept C2780051329 @default.
• W2097621976 hasConcept C71924100 @default.
• W2097621976 hasConcept C86803240 @default.
• W2097621976 hasConceptScore W2097621976C126322002 @default.
• W2097621976 hasConceptScore W2097621976C150903083 @default.
• W2097621976 hasConceptScore W2097621976C15490471 @default.
• W2097621976 hasConceptScore W2097621976C170493617 @default.
• W2097621976 hasConceptScore W2097621976C185263204 @default.
• W2097621976 hasConceptScore W2097621976C201539569 @default.
• W2097621976 hasConceptScore W2097621976C204232928 @default.
• W2097621976 hasConceptScore W2097621976C207001950 @default.
• W2097621976 hasConceptScore W2097621976C24998067 @default.
• W2097621976 hasConceptScore W2097621976C26291073 @default.
• W2097621976 hasConceptScore W2097621976C2779263132 @default.
• W2097621976 hasConceptScore W2097621976C2779794527 @default.
• W2097621976 hasConceptScore W2097621976C2780051329 @default.
• W2097621976 hasConceptScore W2097621976C71924100 @default.
• W2097621976 hasConceptScore W2097621976C86803240 @default.

• next