Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097626443> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2097626443 endingPage "xvii" @default.
- W2097626443 startingPage "xiii" @default.
- W2097626443 abstract "Despite great progress in diagnosis and management of hepatocellular carcinoma (HCC), the exact biology of the tumor remains poorly understood overall limiting the patients’ outcome. Detailed analysis and characterization of the molecular mechanisms and subsequently individual prediction of corresponding prognostic traits would revolutionize both diagnosis and treatment of HCC and is the key goal of modern personalized medicine. Over the recent years systematic approaches for the analysis of whole tumor genomes and transcriptomes as well as epigenomes became affordable tools in translational research. This includes simultaneous analyses of thousands of molecular targets using microarray-based technologies as well as next-generation sequencing. Although currently diagnosis and classification of hepatocellular cancers still rely on histological examination of tumor sections, these technologies show great promise to advance the current knowledge of hepatocarcinogenesis, complement diagnostic classification in a setting of microarray-aided pathology, and rationalize the individual drug selection. This review aims to summarize recent progress of system biological approaches in hepatocarcinogenesis and outline potential areas for translational application in a clinical setting. Further, we give an update about known signaling pathways active in HCC, summarize the historical application of whole genomic approaches in liver cancer and indicate ongoing experimental research utilizing novel technologies in diagnosis and treatment of this deadly disease. This will also include the discussion and characterization of new molecular and cellular targets such as Cancer Stem Cells (CSCs)." @default.
- W2097626443 created "2016-06-24" @default.
- W2097626443 creator A5034659406 @default.
- W2097626443 date "2011-05-01" @default.
- W2097626443 modified "2023-10-18" @default.
- W2097626443 title "Hepatocellular Carcinoma: Its Past, Present, and Future" @default.
- W2097626443 cites W1576665792 @default.
- W2097626443 cites W1590922373 @default.
- W2097626443 cites W1608153977 @default.
- W2097626443 cites W1967231706 @default.
- W2097626443 cites W1972879126 @default.
- W2097626443 cites W2003872175 @default.
- W2097626443 cites W2036449421 @default.
- W2097626443 cites W2051074434 @default.
- W2097626443 cites W2075878333 @default.
- W2097626443 cites W2092705553 @default.
- W2097626443 cites W2319707900 @default.
- W2097626443 cites W2328038297 @default.
- W2097626443 cites W2340231274 @default.
- W2097626443 cites W2490762048 @default.
- W2097626443 cites W2296261114 @default.
- W2097626443 doi "https://doi.org/10.1016/j.cld.2011.04.001" @default.
- W2097626443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21689609" @default.
- W2097626443 hasPublicationYear "2011" @default.
- W2097626443 type Work @default.
- W2097626443 sameAs 2097626443 @default.
- W2097626443 citedByCount "0" @default.
- W2097626443 crossrefType "journal-article" @default.
- W2097626443 hasAuthorship W2097626443A5034659406 @default.
- W2097626443 hasConcept C121608353 @default.
- W2097626443 hasConcept C126322002 @default.
- W2097626443 hasConcept C128544194 @default.
- W2097626443 hasConcept C142724271 @default.
- W2097626443 hasConcept C163763905 @default.
- W2097626443 hasConcept C2778019345 @default.
- W2097626443 hasConcept C32220436 @default.
- W2097626443 hasConcept C502942594 @default.
- W2097626443 hasConcept C60644358 @default.
- W2097626443 hasConcept C70721500 @default.
- W2097626443 hasConcept C71924100 @default.
- W2097626443 hasConcept C86803240 @default.
- W2097626443 hasConceptScore W2097626443C121608353 @default.
- W2097626443 hasConceptScore W2097626443C126322002 @default.
- W2097626443 hasConceptScore W2097626443C128544194 @default.
- W2097626443 hasConceptScore W2097626443C142724271 @default.
- W2097626443 hasConceptScore W2097626443C163763905 @default.
- W2097626443 hasConceptScore W2097626443C2778019345 @default.
- W2097626443 hasConceptScore W2097626443C32220436 @default.
- W2097626443 hasConceptScore W2097626443C502942594 @default.
- W2097626443 hasConceptScore W2097626443C60644358 @default.
- W2097626443 hasConceptScore W2097626443C70721500 @default.
- W2097626443 hasConceptScore W2097626443C71924100 @default.
- W2097626443 hasConceptScore W2097626443C86803240 @default.
- W2097626443 hasIssue "2" @default.
- W2097626443 hasLocation W20976264431 @default.
- W2097626443 hasLocation W20976264432 @default.
- W2097626443 hasOpenAccess W2097626443 @default.
- W2097626443 hasPrimaryLocation W20976264431 @default.
- W2097626443 hasRelatedWork W1903713003 @default.
- W2097626443 hasRelatedWork W2085367843 @default.
- W2097626443 hasRelatedWork W2090483850 @default.
- W2097626443 hasRelatedWork W2117332972 @default.
- W2097626443 hasRelatedWork W2132914709 @default.
- W2097626443 hasRelatedWork W2425884927 @default.
- W2097626443 hasRelatedWork W2748301843 @default.
- W2097626443 hasRelatedWork W3118687486 @default.
- W2097626443 hasRelatedWork W4234654105 @default.
- W2097626443 hasRelatedWork W4313414544 @default.
- W2097626443 hasVolume "15" @default.
- W2097626443 isParatext "false" @default.
- W2097626443 isRetracted "false" @default.
- W2097626443 magId "2097626443" @default.
- W2097626443 workType "article" @default.