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• W2097629498 startingPage "11205" @default.
• W2097629498 abstract "Two major characteristics of baculovirus infection are arrest of the host cell at G2/M phase of the cell cycle with continuing viral DNA replication. We show that Autographa californica nucleopolyhedrovirus (AcMNPV) encodes for a multifunctional cyclin that may partially explain the molecular basis of these important characteristics of AcMNPV (baculovirus) infection. Amino acids 80-110 of the viral structural protein ODV-EC27 (-EC27) demonstrate 25-30% similarity with cellular cyclins within the cyclin box. Immunoprecipitation results using antibodies to -EC27 show that -EC27 can associate with either cdc2 or cdk6 resulting in active kinase complexes that can phosphorylate histone H1 and retinoblastoma protein in vitro. The cdk6-EC27 complex also associates with proliferating cell nuclear antigen (PCNA) and we demonstrate that PCNA is a structural protein of both the budded virus and the occlusion-derived virus. These results suggest that -EC27 can function as a multifunctional cyclin: when associated with cdc2, it exhibits cyclin B-like activity; when associated with cdk6, the complex possesses cyclin D-like activity and binds PCNA. The possible roles of such a multifunctional cyclin during the life cycle of baculovirus are discussed, along with potential implications relative to the expression of functionally authentic recombinant proteins by using baculovirus-infected cells." @default.
• W2097629498 created "2016-06-24" @default.
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• W2097629498 date "1998-09-15" @default.
• W2097629498 modified "2023-09-26" @default.
• W2097629498 title "The structural protein ODV-EC27 of <i>Autographa californica</i> nucleopolyhedrovirus is a multifunctional viral cyclin" @default.
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• W2097629498 doi "https://doi.org/10.1073/pnas.95.19.11205" @default.
• W2097629498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21620" @default.
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• W2097629498 hasPublicationYear "1998" @default.
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