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• W2097645613 endingPage "R87" @default.
• W2097645613 startingPage "R87" @default.
• W2097645613 abstract "Chronic and debilitating low back pain is a common condition and a huge economic burden. Many cases are attributed to age-related degeneration of the intervertebral disc (IVD); however, age-related degeneration appears to occur at an accelerated rate in some individuals. We have previously demonstrated biomarkers of cellular senescence within the human IVD and suggested a role for senescence in IVD degeneration. Senescence occurs with ageing but can also occur prematurely in response to stress. We hypothesised that stress-induced premature senescence (SIPS) occurs within the IVD and here we have investigated the expression and production of caveolin-1, a protein that has been shown previously to be upregulated in SIPS.Caveolin-1 gene expression in human nucleus pulposus (NP) cells was assessed by conventional and quantitative real-time polymerase chain reaction (PCR), and caveolin-1 protein expression was examined within human IVDs using immunohistochemistry. The correlation between caveolin-1 and p16INK4a (biomarker of cellular senescence) gene expression was investigated using quantitative real-time PCR.Caveolin-1 gene expression and protein expression were demonstrated within the human IVD for the first time. NP cells from degenerate discs exhibited elevated levels of caveolin-1 which did not relate to increasing chronological age. A negative correlation was observed between gene expression for caveolin-1 and donor age, and no correlation was found between caveolin-1 protein expression and age. A positive correlation was identified between gene expression of caveolin-1 and p16INK4a.Our findings are consistent with a role for caveolin-1 in degenerative rather than age-induced changes in the NP. Its expression in IVD tissue and its association with the senescent phenotype suggest that caveolin-1 and SIPS may play a prominent role in the pathogenesis of IVD degeneration." @default.
• W2097645613 created "2016-06-24" @default.
• W2097645613 creator A5074888361 @default.
• W2097645613 creator A5075453145 @default.
• W2097645613 creator A5077008748 @default.
• W2097645613 date "2008-01-01" @default.
• W2097645613 modified "2023-10-14" @default.
• W2097645613 title "Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration" @default.
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• W2097645613 doi "https://doi.org/10.1186/ar2468" @default.
• W2097645613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2575636" @default.
• W2097645613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18681962" @default.
• W2097645613 hasPublicationYear "2008" @default.
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