Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097647525> ?p ?o ?g. }
- W2097647525 endingPage "5058" @default.
- W2097647525 startingPage "5043" @default.
- W2097647525 abstract "Assembly of messenger ribonucleoparticles (mRNPs) is a pivotal step in gene expression, but only a few molecular mechanisms contributing to its regulation have been described. Here, through a comprehensive proteomic survey of mRNP assembly, we demonstrate that the SUMO pathway specifically controls the association of the THO complex with mRNPs. We further show that the THO complex, a key player in the interplay between gene expression, mRNA export and genetic stability, is sumoylated on its Hpr1 subunit and that this modification regulates its association with mRNPs. Altered recruitment of the THO complex onto mRNPs in sumoylation-defective mutants does not affect bulk mRNA export or genetic stability, but impairs the expression of acidic stress-induced genes and, consistently, compromises viability in acidic stress conditions. Importantly, inactivation of the nuclear exosome suppresses the phenotypes of the hpr1 non-sumoylatable mutant, showing that SUMO-dependent mRNP assembly is critical to allow a specific subset of mRNPs to escape degradation. This article thus provides the first example of a SUMO-dependent mRNP-assembly event allowing a refined tuning of gene expression, in particular under specific stress conditions." @default.
- W2097647525 created "2016-06-24" @default.
- W2097647525 creator A5020446024 @default.
- W2097647525 creator A5022081737 @default.
- W2097647525 creator A5024915495 @default.
- W2097647525 creator A5049860343 @default.
- W2097647525 creator A5050470987 @default.
- W2097647525 creator A5062684374 @default.
- W2097647525 creator A5087126735 @default.
- W2097647525 date "2014-02-05" @default.
- W2097647525 modified "2023-10-16" @default.
- W2097647525 title "Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs" @default.
- W2097647525 cites W1524671351 @default.
- W2097647525 cites W1544636755 @default.
- W2097647525 cites W1651648648 @default.
- W2097647525 cites W1963504189 @default.
- W2097647525 cites W1965179486 @default.
- W2097647525 cites W1968789240 @default.
- W2097647525 cites W1969131246 @default.
- W2097647525 cites W1971987130 @default.
- W2097647525 cites W1973159404 @default.
- W2097647525 cites W1975593054 @default.
- W2097647525 cites W1975616778 @default.
- W2097647525 cites W1977343831 @default.
- W2097647525 cites W1984537489 @default.
- W2097647525 cites W1985802550 @default.
- W2097647525 cites W1988923344 @default.
- W2097647525 cites W1989644272 @default.
- W2097647525 cites W1995842607 @default.
- W2097647525 cites W2002389726 @default.
- W2097647525 cites W2003907050 @default.
- W2097647525 cites W2012599763 @default.
- W2097647525 cites W2013108773 @default.
- W2097647525 cites W2018106885 @default.
- W2097647525 cites W2019246380 @default.
- W2097647525 cites W2019654388 @default.
- W2097647525 cites W2021776926 @default.
- W2097647525 cites W2032117059 @default.
- W2097647525 cites W2038004197 @default.
- W2097647525 cites W2039741753 @default.
- W2097647525 cites W2041282757 @default.
- W2097647525 cites W2043927273 @default.
- W2097647525 cites W2048596658 @default.
- W2097647525 cites W2049314528 @default.
- W2097647525 cites W2052433275 @default.
- W2097647525 cites W2053806606 @default.
- W2097647525 cites W2058918320 @default.
- W2097647525 cites W2059453176 @default.
- W2097647525 cites W2061845887 @default.
- W2097647525 cites W2065636182 @default.
- W2097647525 cites W2071762846 @default.
- W2097647525 cites W2075152935 @default.
- W2097647525 cites W2076091831 @default.
- W2097647525 cites W2089890829 @default.
- W2097647525 cites W2092586169 @default.
- W2097647525 cites W2097693457 @default.
- W2097647525 cites W2099905512 @default.
- W2097647525 cites W2100041522 @default.
- W2097647525 cites W2102529375 @default.
- W2097647525 cites W2103602723 @default.
- W2097647525 cites W2106403358 @default.
- W2097647525 cites W2106601322 @default.
- W2097647525 cites W2107381484 @default.
- W2097647525 cites W2116635614 @default.
- W2097647525 cites W2121977433 @default.
- W2097647525 cites W2127598257 @default.
- W2097647525 cites W2130443336 @default.
- W2097647525 cites W2130485598 @default.
- W2097647525 cites W2131506546 @default.
- W2097647525 cites W2135197162 @default.
- W2097647525 cites W2136581304 @default.
- W2097647525 cites W2141892665 @default.
- W2097647525 cites W2144359476 @default.
- W2097647525 cites W2145786566 @default.
- W2097647525 cites W2152573239 @default.
- W2097647525 cites W2154583738 @default.
- W2097647525 cites W2157422578 @default.
- W2097647525 cites W2163610346 @default.
- W2097647525 cites W2166998501 @default.
- W2097647525 cites W2168143468 @default.
- W2097647525 cites W2171966548 @default.
- W2097647525 cites W2239140107 @default.
- W2097647525 cites W63988821 @default.
- W2097647525 cites W95252060 @default.
- W2097647525 doi "https://doi.org/10.1093/nar/gku124" @default.
- W2097647525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4005672" @default.
- W2097647525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24500206" @default.
- W2097647525 hasPublicationYear "2014" @default.
- W2097647525 type Work @default.
- W2097647525 sameAs 2097647525 @default.
- W2097647525 citedByCount "46" @default.
- W2097647525 countsByYear W20976475252014 @default.
- W2097647525 countsByYear W20976475252015 @default.
- W2097647525 countsByYear W20976475252016 @default.
- W2097647525 countsByYear W20976475252017 @default.
- W2097647525 countsByYear W20976475252018 @default.
- W2097647525 countsByYear W20976475252019 @default.
- W2097647525 countsByYear W20976475252020 @default.