FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097648001> ?p ?o ?g. }

• W2097648001 endingPage "4266" @default.
• W2097648001 startingPage "4256" @default.
• W2097648001 abstract "Myosin II filament assembly in Dictyostelium discoideum is regulated via phosphorylation of residues located in the carboxyl-terminal portion of the myosin II heavy chain (MHC) tail. A series of novel protein kinases in this system are capable of phosphorylating these residues in vitro, driving filament disassembly. Previous studies have demonstrated that at least three of these kinases (MHCK A, MHCK B, and MHCK C) display differential localization patterns in living cells. We have created a collection of single, double, and triple gene knockout cell lines for this family of kinases. Analysis of these lines reveals that three MHC kinases appear to represent the majority of cellular activity capable of driving myosin II filament disassembly, and reveals that cytokinesis defects increase with the number of kinases disrupted. Using biochemical fractionation of cytoskeletons and in vivo measurements via fluorescence recovery after photobleaching (FRAP), we find that myosin II overassembly increases incrementally in the mutants, with the MHCK A - /B - /C - triple mutant showing severe myosin II overassembly. These studies suggest that the full complement of MHC kinases that significantly contribute to growth phase and cytokinesis myosin II disassembly in this organism has now been identified." @default.
• W2097648001 created "2016-06-24" @default.
• W2097648001 creator A5016389989 @default.
• W2097648001 creator A5016620740 @default.
• W2097648001 creator A5022407492 @default.
• W2097648001 creator A5035566366 @default.
• W2097648001 creator A5036135814 @default.
• W2097648001 creator A5062747104 @default.
• W2097648001 creator A5074349994 @default.
• W2097648001 creator A5080808334 @default.
• W2097648001 date "2005-09-01" @default.
• W2097648001 modified "2023-09-27" @default.
• W2097648001 title "Multiple Myosin II Heavy Chain Kinases: Roles in Filament Assembly Control and Proper Cytokinesis in<i>Dictyostelium</i>" @default.
• W2097648001 cites W1147879691 @default.
• W2097648001 cites W1493538670 @default.
• W2097648001 cites W1562250385 @default.
• W2097648001 cites W1594501126 @default.
• W2097648001 cites W1730571612 @default.
• W2097648001 cites W182333585 @default.
• W2097648001 cites W1986597110 @default.
• W2097648001 cites W1994871685 @default.
• W2097648001 cites W1996479070 @default.
• W2097648001 cites W2006071123 @default.
• W2097648001 cites W2008134353 @default.
• W2097648001 cites W2013120318 @default.
• W2097648001 cites W2013791336 @default.
• W2097648001 cites W2028921328 @default.
• W2097648001 cites W2030385504 @default.
• W2097648001 cites W2032409469 @default.
• W2097648001 cites W2032858775 @default.
• W2097648001 cites W2035716741 @default.
• W2097648001 cites W2036369875 @default.
• W2097648001 cites W2036556323 @default.
• W2097648001 cites W2038537091 @default.
• W2097648001 cites W2043253654 @default.
• W2097648001 cites W2043932132 @default.
• W2097648001 cites W2046508710 @default.
• W2097648001 cites W2051165421 @default.
• W2097648001 cites W2053314239 @default.
• W2097648001 cites W2062963657 @default.
• W2097648001 cites W2063220206 @default.
• W2097648001 cites W2064879119 @default.
• W2097648001 cites W2069133176 @default.
• W2097648001 cites W2069145137 @default.
• W2097648001 cites W2072590905 @default.
• W2097648001 cites W2074941918 @default.
• W2097648001 cites W2076879495 @default.
• W2097648001 cites W2078985369 @default.
• W2097648001 cites W2081204476 @default.
• W2097648001 cites W2083581646 @default.
• W2097648001 cites W2084640600 @default.
• W2097648001 cites W2092236849 @default.
• W2097648001 cites W2105630915 @default.
• W2097648001 cites W2113265094 @default.
• W2097648001 cites W2113951321 @default.
• W2097648001 cites W2114819052 @default.
• W2097648001 cites W2117090318 @default.
• W2097648001 cites W2119568759 @default.
• W2097648001 cites W2126018542 @default.
• W2097648001 cites W2129581196 @default.
• W2097648001 cites W2130138904 @default.
• W2097648001 cites W2140319446 @default.
• W2097648001 cites W2142611569 @default.
• W2097648001 cites W2148285923 @default.
• W2097648001 cites W2148579405 @default.
• W2097648001 cites W2149618351 @default.
• W2097648001 cites W2163595335 @default.
• W2097648001 cites W2166268156 @default.
• W2097648001 cites W2168839000 @default.
• W2097648001 cites W2270899489 @default.
• W2097648001 cites W2345764462 @default.
• W2097648001 cites W253670182 @default.
• W2097648001 cites W2741048540 @default.
• W2097648001 doi "https://doi.org/10.1091/mbc.e05-03-0219" @default.
• W2097648001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1196335" @default.
• W2097648001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15987738" @default.
• W2097648001 hasPublicationYear "2005" @default.
• W2097648001 type Work @default.
• W2097648001 sameAs 2097648001 @default.
• W2097648001 citedByCount "80" @default.
• W2097648001 countsByYear W20976480012012 @default.
• W2097648001 countsByYear W20976480012013 @default.
• W2097648001 countsByYear W20976480012014 @default.
• W2097648001 countsByYear W20976480012015 @default.
• W2097648001 countsByYear W20976480012016 @default.
• W2097648001 countsByYear W20976480012017 @default.
• W2097648001 countsByYear W20976480012018 @default.
• W2097648001 countsByYear W20976480012019 @default.
• W2097648001 countsByYear W20976480012021 @default.
• W2097648001 countsByYear W20976480012023 @default.
• W2097648001 crossrefType "journal-article" @default.
• W2097648001 hasAuthorship W2097648001A5016389989 @default.
• W2097648001 hasAuthorship W2097648001A5016620740 @default.
• W2097648001 hasAuthorship W2097648001A5022407492 @default.
• W2097648001 hasAuthorship W2097648001A5035566366 @default.
• W2097648001 hasAuthorship W2097648001A5036135814 @default.
• W2097648001 hasAuthorship W2097648001A5062747104 @default.
• W2097648001 hasAuthorship W2097648001A5074349994 @default.

• next