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• W2097652097 endingPage "1194" @default.
• W2097652097 startingPage "1187" @default.
• W2097652097 abstract "Cytokine driven or bystander proliferation of T cells occurs in vivo independently of major histocompatibility complex-T cell receptor interactions. This process may be important for supporting T cell homeostasis and facilitating T cell responses to microbial antigens, and may involve the cytokine interleukin (IL)-15. In this study, we find that IL-15Ralpha-deficient (IL-15Ralpha(-/-)) mice fail to undergo poly I:C or IL-15 driven bystander proliferation of CD8(+) T cells. Surprisingly, IL-15Ralpha(-/-) CD8(+) T cells proliferate in response to poly I:C when adoptively transferred into normal mice, and normal CD8(+) T cells fail to proliferate in IL-15Ralpha(-/-) mice. Normal mice reconstituted with IL-15Ralpha(-/-) bone marrow cells also fail to exhibit bystander responses. Thus, CD8(+) T cell independent IL-15Ralpha signals from radiation sensitive hematopoietic cells are likely required for bystander responses. Moreover, normal CD8(+) T cells proliferate in IL-15Ralpha(-/-) mice after treatment with IL-15. Therefore, IL-15Ralpha signals may mediate a positive feedback loop involving the further physiological production of IL-15. These findings provide new insights into how IL-15Ralpha supports memory phenotype CD8(+) T cell proliferation, and suggest novel mechanisms by which memory CD8(+) T cells are maintained in vivo." @default.
• W2097652097 created "2016-06-24" @default.
• W2097652097 creator A5002583582 @default.
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• W2097652097 creator A5066436537 @default.
• W2097652097 date "2001-10-15" @default.
• W2097652097 modified "2023-10-09" @default.
• W2097652097 title "T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation" @default.
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• W2097652097 doi "https://doi.org/10.1084/jem.194.8.1187" @default.
• W2097652097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193508" @default.
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