FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097660315> ?p ?o ?g. }

• W2097660315 abstract "Brain-derived neurotrophic factor (BDNF) is a small secreted protein that has important roles in the developing and adult nervous system. Altered expression or changes in the regulation of the BDNF gene have been implicated in a variety of human nervous system disorders. Although regulation of the rodent BDNF gene has been extensively investigated, in vivo studies regarding the human BDNF gene are largely limited to postmortem analysis. Bacterial artificial chromosome (BAC) transgenic mice harboring the human BDNF gene and its regulatory flanking sequences constitute a useful tool for studying human BDNF gene regulation and for identification of therapeutic compounds modulating BDNF expression.In this study we have generated and analyzed BAC transgenic mice carrying 168 kb of the human BDNF locus modified such that BDNF coding sequence was replaced with the sequence of a fusion protein consisting of N-terminal BDNF and the enhanced green fluorescent protein (EGFP). The human BDNF-BAC construct containing all BDNF 5' exons preceded by different promoters recapitulated the expression of endogenous BDNF mRNA in the brain and several non-neural tissues of transgenic mice. All different 5' exon-specific BDNF-EGFP alternative transcripts were expressed from the transgenic human BDNF-BAC construct, resembling the expression of endogenous BDNF. Furthermore, BDNF-EGFP mRNA was induced upon treatment with kainic acid in a promotor-specific manner, similarly to that of the endogenous mouse BDNF mRNA.Genomic region covering 67 kb of human BDNF gene, 84 kb of upstream and 17 kb of downstream sequences is sufficient to drive tissue-specific and kainic acid-induced expression of the reporter gene in transgenic mice. The pattern of expression of the transgene is highly similar to BDNF gene expression in mouse and human. This is the first study to show that human BDNF gene is regulated by neural activity." @default.
• W2097660315 created "2016-06-24" @default.
• W2097660315 creator A5013627484 @default.
• W2097660315 creator A5014174188 @default.
• W2097660315 creator A5048697133 @default.
• W2097660315 creator A5053706301 @default.
• W2097660315 creator A5058584657 @default.
• W2097660315 creator A5062244268 @default.
• W2097660315 creator A5067755753 @default.
• W2097660315 date "2009-06-25" @default.
• W2097660315 modified "2023-10-06" @default.
• W2097660315 title "Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice" @default.
• W2097660315 cites W1555679702 @default.
• W2097660315 cites W1830398839 @default.
• W2097660315 cites W1966785609 @default.
• W2097660315 cites W1975136608 @default.
• W2097660315 cites W1982889157 @default.
• W2097660315 cites W1983706324 @default.
• W2097660315 cites W1992529363 @default.
• W2097660315 cites W1998271864 @default.
• W2097660315 cites W1999372723 @default.
• W2097660315 cites W1999537405 @default.
• W2097660315 cites W2000540402 @default.
• W2097660315 cites W2000637724 @default.
• W2097660315 cites W2002637584 @default.
• W2097660315 cites W2007105554 @default.
• W2097660315 cites W2010050518 @default.
• W2097660315 cites W2010643654 @default.
• W2097660315 cites W2011015261 @default.
• W2097660315 cites W2015450452 @default.
• W2097660315 cites W2018418687 @default.
• W2097660315 cites W2020215900 @default.
• W2097660315 cites W2025153944 @default.
• W2097660315 cites W2029565457 @default.
• W2097660315 cites W2031269976 @default.
• W2097660315 cites W2033367566 @default.
• W2097660315 cites W2038563688 @default.
• W2097660315 cites W2039255376 @default.
• W2097660315 cites W2039753950 @default.
• W2097660315 cites W2047225543 @default.
• W2097660315 cites W2051600135 @default.
• W2097660315 cites W2058861807 @default.
• W2097660315 cites W2064756990 @default.
• W2097660315 cites W2079472132 @default.
• W2097660315 cites W2080428182 @default.
• W2097660315 cites W2089454493 @default.
• W2097660315 cites W2099226119 @default.
• W2097660315 cites W2109807917 @default.
• W2097660315 cites W2115487032 @default.
• W2097660315 cites W2117830068 @default.
• W2097660315 cites W2121171425 @default.
• W2097660315 cites W2124366353 @default.
• W2097660315 cites W2126541199 @default.
• W2097660315 cites W2130837565 @default.
• W2097660315 cites W2139087276 @default.
• W2097660315 cites W2153851340 @default.
• W2097660315 cites W2157616236 @default.
• W2097660315 cites W2161649767 @default.
• W2097660315 cites W2409059154 @default.
• W2097660315 cites W62779527 @default.
• W2097660315 doi "https://doi.org/10.1186/1471-2202-10-68" @default.
• W2097660315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2708170" @default.
• W2097660315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19555478" @default.
• W2097660315 hasPublicationYear "2009" @default.
• W2097660315 type Work @default.
• W2097660315 sameAs 2097660315 @default.
• W2097660315 citedByCount "34" @default.
• W2097660315 countsByYear W20976603152012 @default.
• W2097660315 countsByYear W20976603152013 @default.
• W2097660315 countsByYear W20976603152014 @default.
• W2097660315 countsByYear W20976603152017 @default.
• W2097660315 countsByYear W20976603152018 @default.
• W2097660315 countsByYear W20976603152019 @default.
• W2097660315 countsByYear W20976603152020 @default.
• W2097660315 countsByYear W20976603152022 @default.
• W2097660315 countsByYear W20976603152023 @default.
• W2097660315 crossrefType "journal-article" @default.
• W2097660315 hasAuthorship W2097660315A5013627484 @default.
• W2097660315 hasAuthorship W2097660315A5014174188 @default.
• W2097660315 hasAuthorship W2097660315A5048697133 @default.
• W2097660315 hasAuthorship W2097660315A5053706301 @default.
• W2097660315 hasAuthorship W2097660315A5058584657 @default.
• W2097660315 hasAuthorship W2097660315A5062244268 @default.
• W2097660315 hasAuthorship W2097660315A5067755753 @default.
• W2097660315 hasBestOaLocation W20976603151 @default.
• W2097660315 hasConcept C101762097 @default.
• W2097660315 hasConcept C102230213 @default.
• W2097660315 hasConcept C104317684 @default.
• W2097660315 hasConcept C141035611 @default.
• W2097660315 hasConcept C141231307 @default.
• W2097660315 hasConcept C150194340 @default.
• W2097660315 hasConcept C153911025 @default.
• W2097660315 hasConcept C160539049 @default.
• W2097660315 hasConcept C170493617 @default.
• W2097660315 hasConcept C182901222 @default.
• W2097660315 hasConcept C2778790584 @default.
• W2097660315 hasConcept C36823959 @default.
• W2097660315 hasConcept C54355233 @default.
• W2097660315 hasConcept C86803240 @default.
• W2097660315 hasConceptScore W2097660315C101762097 @default.

• next