FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097660561> ?p ?o ?g. }

• W2097660561 endingPage "150" @default.
• W2097660561 startingPage "145" @default.
• W2097660561 abstract "Vaginal microbicides with activity towards organisms that cause sexually transmitted infections have been proposed as a strategy to reduce transmission. Small-molecule inhibitors of Chlamydia trachomatis serovar D belonging to the class of salicylidene acylhydrazides (INPs) have been shown to work through a mechanism that involves iron restriction. Expanding on this work, ten INPs were tested against a lymphogranuloma venereum strain of C. trachomatis (serovar L2), Neisseria gonorrhoeae, and hydrogen peroxide-producing Lactobacillus crispatus and Lactobacillus jensenii. Seven INPs had minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations of <50 microM towards C. trachomatis L2. Three INPs had a MIC <12.5 microM against N. gonorrhoeae. Inhibition was reversed by iron, holo-transferrin and holo-lactoferrin but not by the iron-poor forms of these compounds. The compounds exhibited no bactericidal activity toward Lactobacillus. The INPs were not cytotoxic to HeLa 229 cells. When INP 0341 was tested in a mouse model of a Chlamydia vaginal infection there was a significant reduction in the number of mice shedding C. trachomatis up to 4 days after infection (P<0.01). In summary, select INPs are promising vaginal microbicide candidates as they inhibit the growth of two common sexually transmitted organisms in vitro, are active in a mouse model against C. trachomatis, are not cytotoxic and do not inhibit organisms that compose the normal vaginal flora." @default.
• W2097660561 created "2016-06-24" @default.
• W2097660561 creator A5020480735 @default.
• W2097660561 creator A5034132050 @default.
• W2097660561 creator A5072343210 @default.
• W2097660561 creator A5079343949 @default.
• W2097660561 creator A5083338554 @default.
• W2097660561 creator A5089455520 @default.
• W2097660561 date "2010-08-01" @default.
• W2097660561 modified "2023-09-27" @default.
• W2097660561 title "Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseriagonorrhoeae" @default.
• W2097660561 cites W1525927184 @default.
• W2097660561 cites W1732639328 @default.
• W2097660561 cites W1764884642 @default.
• W2097660561 cites W1963852477 @default.
• W2097660561 cites W2015150314 @default.
• W2097660561 cites W2036479803 @default.
• W2097660561 cites W2049257708 @default.
• W2097660561 cites W2050372129 @default.
• W2097660561 cites W2054233015 @default.
• W2097660561 cites W2055044450 @default.
• W2097660561 cites W2062078248 @default.
• W2097660561 cites W2062635872 @default.
• W2097660561 cites W2067761117 @default.
• W2097660561 cites W2070953605 @default.
• W2097660561 cites W2088090286 @default.
• W2097660561 cites W2089282357 @default.
• W2097660561 cites W2090144339 @default.
• W2097660561 cites W2096714863 @default.
• W2097660561 cites W2099271394 @default.
• W2097660561 cites W2100206933 @default.
• W2097660561 cites W2102967627 @default.
• W2097660561 cites W2107367202 @default.
• W2097660561 cites W2116037614 @default.
• W2097660561 cites W2124347199 @default.
• W2097660561 cites W2126566142 @default.
• W2097660561 cites W2127541870 @default.
• W2097660561 cites W2130975561 @default.
• W2097660561 cites W2145391341 @default.
• W2097660561 cites W2154724511 @default.
• W2097660561 cites W2160010002 @default.
• W2097660561 cites W2162713320 @default.
• W2097660561 cites W2164095252 @default.
• W2097660561 cites W2165524414 @default.
• W2097660561 cites W2170489997 @default.
• W2097660561 doi "https://doi.org/10.1016/j.ijantimicag.2010.03.018" @default.
• W2097660561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2902681" @default.
• W2097660561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20605703" @default.
• W2097660561 hasPublicationYear "2010" @default.
• W2097660561 type Work @default.
• W2097660561 sameAs 2097660561 @default.
• W2097660561 citedByCount "32" @default.
• W2097660561 countsByYear W20976605612012 @default.
• W2097660561 countsByYear W20976605612013 @default.
• W2097660561 countsByYear W20976605612014 @default.
• W2097660561 countsByYear W20976605612015 @default.
• W2097660561 countsByYear W20976605612016 @default.
• W2097660561 countsByYear W20976605612017 @default.
• W2097660561 countsByYear W20976605612018 @default.
• W2097660561 countsByYear W20976605612019 @default.
• W2097660561 countsByYear W20976605612020 @default.
• W2097660561 countsByYear W20976605612021 @default.
• W2097660561 countsByYear W20976605612022 @default.
• W2097660561 crossrefType "journal-article" @default.
• W2097660561 hasAuthorship W2097660561A5020480735 @default.
• W2097660561 hasAuthorship W2097660561A5034132050 @default.
• W2097660561 hasAuthorship W2097660561A5072343210 @default.
• W2097660561 hasAuthorship W2097660561A5079343949 @default.
• W2097660561 hasAuthorship W2097660561A5083338554 @default.
• W2097660561 hasAuthorship W2097660561A5089455520 @default.
• W2097660561 hasBestOaLocation W20976605612 @default.
• W2097660561 hasConcept C117214928 @default.
• W2097660561 hasConcept C159047783 @default.
• W2097660561 hasConcept C197746943 @default.
• W2097660561 hasConcept C2776334974 @default.
• W2097660561 hasConcept C2776983459 @default.
• W2097660561 hasConcept C2777391075 @default.
• W2097660561 hasConcept C2777831542 @default.
• W2097660561 hasConcept C2779166590 @default.
• W2097660561 hasConcept C2779170986 @default.
• W2097660561 hasConcept C2779952448 @default.
• W2097660561 hasConcept C2780206646 @default.
• W2097660561 hasConcept C2780236403 @default.
• W2097660561 hasConcept C2908647359 @default.
• W2097660561 hasConcept C2909760446 @default.
• W2097660561 hasConcept C2986740045 @default.
• W2097660561 hasConcept C3013748606 @default.
• W2097660561 hasConcept C523546767 @default.
• W2097660561 hasConcept C54355233 @default.
• W2097660561 hasConcept C55493867 @default.
• W2097660561 hasConcept C71924100 @default.
• W2097660561 hasConcept C86803240 @default.
• W2097660561 hasConcept C89423630 @default.
• W2097660561 hasConcept C99454951 @default.
• W2097660561 hasConceptScore W2097660561C117214928 @default.
• W2097660561 hasConceptScore W2097660561C159047783 @default.
• W2097660561 hasConceptScore W2097660561C197746943 @default.
• W2097660561 hasConceptScore W2097660561C2776334974 @default.

• next