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• W2097665802 abstract "ABSTRACT Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer. SOS is a dual-function guanine nucleotide exchange factor (GEF) that catalyzes exchange on Ras and Rac. Although the physiologic role of SOS and its CDC25 domain in RTK-mediated Ras activation is well established, the in vivo function of its Dbl Rac GEF domain is less clear. We have identified a novel gain-of-function missense mutation in the Dbl domain of Caenorhabditis elegans SOS-1 that promotes epidermal growth factor receptor (EGFR) signaling in vivo. Our data indicate that a major developmental function of the Dbl domain is to inhibit EGF-dependent MAPK activation. The amount of inhibition conferred by the Dbl domain is equal to that of established trans -acting inhibitors of the EGFR pathway, including c-Cbl and RasGAP, and more than that of MAPK phosphatase. In conjunction with molecular modeling, our data suggest that the C. elegans mutation, as well as an equivalent mutation in human SOS1, activates the MAPK pathway by disrupting an autoinhibitory function of the Dbl domain on Ras activation. Our work suggests that functionally similar point mutations in humans could directly contribute to disease." @default.
• W2097665802 created "2016-06-24" @default.
• W2097665802 creator A5007563372 @default.
• W2097665802 creator A5017860475 @default.
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• W2097665802 creator A5050321521 @default.
• W2097665802 creator A5077218621 @default.
• W2097665802 creator A5079763267 @default.
• W2097665802 creator A5085363856 @default.
• W2097665802 date "2007-05-15" @default.
• W2097665802 modified "2023-09-25" @default.
• W2097665802 title "An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development" @default.
• W2097665802 cites W1249078729 @default.
• W2097665802 cites W1431123654 @default.
• W2097665802 cites W1488372279 @default.
• W2097665802 cites W1512355975 @default.
• W2097665802 cites W1533988685 @default.
• W2097665802 cites W1541741307 @default.
• W2097665802 cites W1639582946 @default.
• W2097665802 cites W1666849257 @default.
• W2097665802 cites W1757453545 @default.
• W2097665802 cites W1815825113 @default.
• W2097665802 cites W1824220821 @default.
• W2097665802 cites W1869944834 @default.
• W2097665802 cites W1880291900 @default.
• W2097665802 cites W1880356065 @default.
• W2097665802 cites W1908868115 @default.
• W2097665802 cites W1924646174 @default.
• W2097665802 cites W1944127002 @default.
• W2097665802 cites W1946787458 @default.
• W2097665802 cites W1967882942 @default.
• W2097665802 cites W1969695222 @default.
• W2097665802 cites W1971475788 @default.
• W2097665802 cites W1972812612 @default.
• W2097665802 cites W1978987987 @default.
• W2097665802 cites W1985288684 @default.
• W2097665802 cites W1993837490 @default.
• W2097665802 cites W2001121496 @default.
• W2097665802 cites W2001234795 @default.
• W2097665802 cites W2003319634 @default.
• W2097665802 cites W2007962912 @default.
• W2097665802 cites W2010926229 @default.
• W2097665802 cites W2013592169 @default.
• W2097665802 cites W2015642465 @default.
• W2097665802 cites W2015889211 @default.
• W2097665802 cites W2017209948 @default.
• W2097665802 cites W2027579998 @default.
• W2097665802 cites W2033068296 @default.
• W2097665802 cites W2036887265 @default.
• W2097665802 cites W2037311996 @default.
• W2097665802 cites W2037717289 @default.
• W2097665802 cites W2038492783 @default.
• W2097665802 cites W2039247434 @default.
• W2097665802 cites W2041386911 @default.
• W2097665802 cites W2041963256 @default.
• W2097665802 cites W2043698607 @default.
• W2097665802 cites W2048937265 @default.
• W2097665802 cites W2051541090 @default.
• W2097665802 cites W2052799365 @default.
• W2097665802 cites W2055013423 @default.
• W2097665802 cites W2057193041 @default.
• W2097665802 cites W2057982431 @default.
• W2097665802 cites W2058282339 @default.
• W2097665802 cites W2058778918 @default.
• W2097665802 cites W2060809301 @default.
• W2097665802 cites W2060840912 @default.
• W2097665802 cites W2061920396 @default.
• W2097665802 cites W2066844640 @default.
• W2097665802 cites W2067554394 @default.
• W2097665802 cites W2068804834 @default.
• W2097665802 cites W2070204715 @default.
• W2097665802 cites W2071850213 @default.
• W2097665802 cites W2075517727 @default.
• W2097665802 cites W2077689653 @default.
• W2097665802 cites W2078792788 @default.
• W2097665802 cites W2082448876 @default.
• W2097665802 cites W2083932821 @default.
• W2097665802 cites W2085136839 @default.
• W2097665802 cites W2087491465 @default.
• W2097665802 cites W2088514516 @default.
• W2097665802 cites W2090105213 @default.
• W2097665802 cites W2097708657 @default.
• W2097665802 cites W2098377849 @default.
• W2097665802 cites W2109781110 @default.
• W2097665802 cites W2113661578 @default.
• W2097665802 cites W2114950222 @default.
• W2097665802 cites W2116241226 @default.
• W2097665802 cites W2120879594 @default.
• W2097665802 cites W2129595021 @default.
• W2097665802 cites W2134611436 @default.
• W2097665802 cites W2138388305 @default.
• W2097665802 cites W2143066563 @default.
• W2097665802 cites W2143442755 @default.
• W2097665802 cites W2143624084 @default.
• W2097665802 cites W2143934185 @default.
• W2097665802 cites W2152561142 @default.
• W2097665802 cites W2155947794 @default.

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