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- W2097671522 abstract "Hormone-dependent cancers of the prostate and breast are the most common cancers in men and women, respec- tively, in the Western world and are major causes of illness and death. Current diagnostic/prognostic tests are invasive or lack specificity and certainty with respect to detecting these cancers early and in differentiating between different phenotypes. More specific diagnostic/prognostic markers are needed to better define treatment options for individuals. Classical approaches have fo - cussed on candidate genes/proteins that are involved in tumour cell growth, invasion and metastasis. Using genomic, proteomic, molecular and cell biology approaches in vitro, we have identified additional proteins - the ghrelin growth factor axis and variants within the kallikrein family of serine proteases - that may serve as potential candidate markers and therapeutic targets. However, with recent advances in high through-put technologies (gene tissue microarrays, 2D gel and mass spectrometry proteome analy- ses, bioinformatics) relevant genes/proteins can now be more efficiently screened, identified and validated. These technologies can readily be coupled with proof-of-principle experiments - in vitro and in vivo assays using gain and loss of function models, targeted drug design and pharmacological/toxicological studies and subsequent clinical trials - to develop a fully integrated, translational research model which has the capacity to deliver clinical outcomes more rapidly." @default.
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- W2097671522 date "2010-01-01" @default.
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- W2097671522 title "Hormone-dependent cancers: New approaches to identification of potential diagnostic and/or therapeutic biomarkers" @default.
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