Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097678737> ?p ?o ?g. }
- W2097678737 endingPage "692" @default.
- W2097678737 startingPage "665" @default.
- W2097678737 abstract "17β-Hydroxysteroid dehydrogenases (17β-HSDs) are enzymes that are responsible for reduction or oxidation of hormones, fatty acids and bile acids in vivo, regulating the amount of the active form that is available to bind to its cognate receptor. All require NAD(P)(H) for activity. Fifteen 17β-HSDs have been identified to date, and with one exception, 17β-HSD type 5 (17β-HSD5), an aldo–keto reductase, they are all short-chain dehydrogenases/reductases, although overall homology between the enzymes is low. Although named as 17β-HSDs, reflecting the major redox activity at the 17β-position of the steroid, the activities of these 15 enzymes vary, with several of the 17β-HSDs able to reduce and/or oxidise multiple substrates at various positions. These activities are involved in the progression of a number of diseases, including those related to steroid metabolism. Despite the success of inhibitors of steroidogenic enzymes in the clinic, such as those of aromatase and steroid sulphatase, the development of inhibitors of 17β-HSDs is at a relatively early stage, as at present none have yet reached clinical trials. However, many groups are now working on inhibitors specific for several of these enzymes for the treatment of steroid-dependent diseases, including breast and prostate cancer, and endometriosis, with demonstrable efficacy in in vivo disease models. In this review, the recent advances in the validation of these enzymes as targets for the treatment of these diseases, with emphasis on 17β-HSD1, 3 and 5, the development of specific inhibitors, the models used for their evaluation, and their progress towards the clinic will be discussed." @default.
- W2097678737 created "2016-06-24" @default.
- W2097678737 creator A5013024538 @default.
- W2097678737 creator A5013687413 @default.
- W2097678737 creator A5017572010 @default.
- W2097678737 creator A5057398969 @default.
- W2097678737 date "2008-05-22" @default.
- W2097678737 modified "2023-10-11" @default.
- W2097678737 title "Design and validation of specific inhibitors of 17 -hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis" @default.
- W2097678737 cites W102529405 @default.
- W2097678737 cites W1485838909 @default.
- W2097678737 cites W1504120770 @default.
- W2097678737 cites W1505074350 @default.
- W2097678737 cites W1518598430 @default.
- W2097678737 cites W1532886081 @default.
- W2097678737 cites W1556105090 @default.
- W2097678737 cites W1559119765 @default.
- W2097678737 cites W1568528806 @default.
- W2097678737 cites W1638056980 @default.
- W2097678737 cites W1833278024 @default.
- W2097678737 cites W1911110831 @default.
- W2097678737 cites W1963891525 @default.
- W2097678737 cites W1964176572 @default.
- W2097678737 cites W1964867878 @default.
- W2097678737 cites W1968728238 @default.
- W2097678737 cites W1969139383 @default.
- W2097678737 cites W1970546734 @default.
- W2097678737 cites W1970687343 @default.
- W2097678737 cites W1971584634 @default.
- W2097678737 cites W1972644675 @default.
- W2097678737 cites W1973031039 @default.
- W2097678737 cites W1973109666 @default.
- W2097678737 cites W1973618891 @default.
- W2097678737 cites W1974702163 @default.
- W2097678737 cites W1976701520 @default.
- W2097678737 cites W1976710551 @default.
- W2097678737 cites W1976875853 @default.
- W2097678737 cites W1978649931 @default.
- W2097678737 cites W1978718013 @default.
- W2097678737 cites W1978890163 @default.
- W2097678737 cites W1979176327 @default.
- W2097678737 cites W1980061538 @default.
- W2097678737 cites W1980738399 @default.
- W2097678737 cites W1981674621 @default.
- W2097678737 cites W1984055799 @default.
- W2097678737 cites W1987241837 @default.
- W2097678737 cites W1988348552 @default.
- W2097678737 cites W1988641645 @default.
- W2097678737 cites W1989360072 @default.
- W2097678737 cites W1993354065 @default.
- W2097678737 cites W1994014953 @default.
- W2097678737 cites W1995478133 @default.
- W2097678737 cites W1998013551 @default.
- W2097678737 cites W2000207142 @default.
- W2097678737 cites W2000231383 @default.
- W2097678737 cites W2002119555 @default.
- W2097678737 cites W2002726977 @default.
- W2097678737 cites W2003550137 @default.
- W2097678737 cites W2003862617 @default.
- W2097678737 cites W2004356408 @default.
- W2097678737 cites W2006069482 @default.
- W2097678737 cites W2006788503 @default.
- W2097678737 cites W2007245161 @default.
- W2097678737 cites W2007846797 @default.
- W2097678737 cites W2007977414 @default.
- W2097678737 cites W2008690941 @default.
- W2097678737 cites W2009230922 @default.
- W2097678737 cites W2010311608 @default.
- W2097678737 cites W2010355774 @default.
- W2097678737 cites W2011178421 @default.
- W2097678737 cites W2011478728 @default.
- W2097678737 cites W2011974240 @default.
- W2097678737 cites W2012707556 @default.
- W2097678737 cites W2013857643 @default.
- W2097678737 cites W2016183786 @default.
- W2097678737 cites W2017724017 @default.
- W2097678737 cites W2019786804 @default.
- W2097678737 cites W2020259519 @default.
- W2097678737 cites W2020434370 @default.
- W2097678737 cites W2021595443 @default.
- W2097678737 cites W2022574700 @default.
- W2097678737 cites W2024268846 @default.
- W2097678737 cites W2024812969 @default.
- W2097678737 cites W2025141558 @default.
- W2097678737 cites W2025726852 @default.
- W2097678737 cites W2026352933 @default.
- W2097678737 cites W2026975038 @default.
- W2097678737 cites W2028085462 @default.
- W2097678737 cites W2028916314 @default.
- W2097678737 cites W2029852236 @default.
- W2097678737 cites W2030180880 @default.
- W2097678737 cites W2030564045 @default.
- W2097678737 cites W2030761095 @default.
- W2097678737 cites W2031384067 @default.
- W2097678737 cites W2032228785 @default.
- W2097678737 cites W2034303217 @default.
- W2097678737 cites W2034336918 @default.
- W2097678737 cites W2038850987 @default.