FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097687613> ?p ?o ?g. }

• W2097687613 endingPage "1633" @default.
• W2097687613 startingPage "1625" @default.
• W2097687613 abstract "During embryonic development, Drosophila macrophages (haemocytes) undergo a series of stereotypical migrations to disperse throughout the embryo. One major migratory route is along the ventral nerve cord (VNC), where haemocytes are required for the correct development of this tissue. We show, for the first time, that a reciprocal relationship exists between haemocytes and the VNC and that defects in nerve cord development prevent haemocyte migration along this structure. Using live imaging, we demonstrate that the axonal guidance cue Slit and its receptor Robo are both required for haemocyte migration, but signalling is not autonomously required in haemocytes. We show that the failure of haemocyte migration along the VNC in slit mutants is not due to a lack of chemotactic signals within this structure, but rather to a failure in its detachment from the overlying epithelium, creating a physical barrier to haemocyte migration. This block of haemocyte migration in turn disrupts the formation of the dorsoventral channels within the VNC, further highlighting the importance of haemocyte migration for correct neural development. This study illustrates the important role played by the three-dimensional environment in directing cell migration in vivo and reveals an intriguing interplay between the developing nervous system and the blood cells within the fly, demonstrating that their development is both closely coupled and interdependent." @default.
• W2097687613 created "2016-06-24" @default.
• W2097687613 creator A5007517777 @default.
• W2097687613 creator A5015920256 @default.
• W2097687613 creator A5017561426 @default.
• W2097687613 creator A5042365967 @default.
• W2097687613 date "2010-05-15" @default.
• W2097687613 modified "2023-09-30" @default.
• W2097687613 title "Interdependence of macrophage migration and ventral nerve cord development in <i>Drosophila</i> embryos" @default.
• W2097687613 cites W1967291020 @default.
• W2097687613 cites W1970821956 @default.
• W2097687613 cites W1977381126 @default.
• W2097687613 cites W1982650114 @default.
• W2097687613 cites W1983075472 @default.
• W2097687613 cites W1996775753 @default.
• W2097687613 cites W2005215351 @default.
• W2097687613 cites W2005969089 @default.
• W2097687613 cites W2009865010 @default.
• W2097687613 cites W2013571088 @default.
• W2097687613 cites W2017133589 @default.
• W2097687613 cites W2019129382 @default.
• W2097687613 cites W2024255736 @default.
• W2097687613 cites W2024631862 @default.
• W2097687613 cites W2045124544 @default.
• W2097687613 cites W2051656608 @default.
• W2097687613 cites W2051782048 @default.
• W2097687613 cites W2053683231 @default.
• W2097687613 cites W2063751484 @default.
• W2097687613 cites W2068423407 @default.
• W2097687613 cites W2068627747 @default.
• W2097687613 cites W2073133778 @default.
• W2097687613 cites W2107508493 @default.
• W2097687613 cites W2115062156 @default.
• W2097687613 cites W2127432537 @default.
• W2097687613 cites W2128910881 @default.
• W2097687613 cites W2134090916 @default.
• W2097687613 cites W2135653120 @default.
• W2097687613 cites W2136243233 @default.
• W2097687613 cites W2138028202 @default.
• W2097687613 cites W2141461445 @default.
• W2097687613 cites W2141932361 @default.
• W2097687613 cites W2146337027 @default.
• W2097687613 cites W2152190286 @default.
• W2097687613 cites W2152911705 @default.
• W2097687613 cites W2153201281 @default.
• W2097687613 cites W2166445583 @default.
• W2097687613 cites W2168344733 @default.
• W2097687613 doi "https://doi.org/10.1242/dev.046797" @default.
• W2097687613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860247" @default.
• W2097687613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20392742" @default.
• W2097687613 hasPublicationYear "2010" @default.
• W2097687613 type Work @default.
• W2097687613 sameAs 2097687613 @default.
• W2097687613 citedByCount "49" @default.
• W2097687613 countsByYear W20976876132012 @default.
• W2097687613 countsByYear W20976876132013 @default.
• W2097687613 countsByYear W20976876132014 @default.
• W2097687613 countsByYear W20976876132015 @default.
• W2097687613 countsByYear W20976876132016 @default.
• W2097687613 countsByYear W20976876132017 @default.
• W2097687613 countsByYear W20976876132018 @default.
• W2097687613 countsByYear W20976876132019 @default.
• W2097687613 countsByYear W20976876132020 @default.
• W2097687613 countsByYear W20976876132021 @default.
• W2097687613 countsByYear W20976876132022 @default.
• W2097687613 countsByYear W20976876132023 @default.
• W2097687613 crossrefType "journal-article" @default.
• W2097687613 hasAuthorship W2097687613A5007517777 @default.
• W2097687613 hasAuthorship W2097687613A5015920256 @default.
• W2097687613 hasAuthorship W2097687613A5017561426 @default.
• W2097687613 hasAuthorship W2097687613A5042365967 @default.
• W2097687613 hasBestOaLocation W20976876131 @default.
• W2097687613 hasConcept C104317684 @default.
• W2097687613 hasConcept C105702510 @default.
• W2097687613 hasConcept C137738243 @default.
• W2097687613 hasConcept C1491633281 @default.
• W2097687613 hasConcept C15526883 @default.
• W2097687613 hasConcept C158944026 @default.
• W2097687613 hasConcept C169760540 @default.
• W2097687613 hasConcept C196843134 @default.
• W2097687613 hasConcept C199215989 @default.
• W2097687613 hasConcept C2780104201 @default.
• W2097687613 hasConcept C2780594696 @default.
• W2097687613 hasConcept C40692019 @default.
• W2097687613 hasConcept C54355233 @default.
• W2097687613 hasConcept C545706735 @default.
• W2097687613 hasConcept C86803240 @default.
• W2097687613 hasConcept C95444343 @default.
• W2097687613 hasConceptScore W2097687613C104317684 @default.
• W2097687613 hasConceptScore W2097687613C105702510 @default.
• W2097687613 hasConceptScore W2097687613C137738243 @default.
• W2097687613 hasConceptScore W2097687613C1491633281 @default.
• W2097687613 hasConceptScore W2097687613C15526883 @default.
• W2097687613 hasConceptScore W2097687613C158944026 @default.
• W2097687613 hasConceptScore W2097687613C169760540 @default.
• W2097687613 hasConceptScore W2097687613C196843134 @default.
• W2097687613 hasConceptScore W2097687613C199215989 @default.
• W2097687613 hasConceptScore W2097687613C2780104201 @default.

• next