Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097688080> ?p ?o ?g. }
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- W2097688080 abstract "Plasma protein binding of drugs is a well-recognised phenomena, but it is only recently that the implications for drug action in vivo have been fully appreciated. Plasma proteins, by virtue of their high concentration, control the free drug concentration in plasma and in compartments in equilibrium with plasma, thereby, effectively attenuating drug potency in vivo. The historical background and thermodynamic basis for the ‘Free Drug Principle’ is presented, along with special considerations for intracellular targets, deep compartments and α1-acid glycoprotein binding. Real and apparent exceptions to the principle are discussed along with a survey of citations from the recent medicinal chemistry literature." @default.
- W2097688080 created "2016-06-24" @default.
- W2097688080 creator A5057427778 @default.
- W2097688080 date "2007-01-01" @default.
- W2097688080 modified "2023-10-02" @default.
- W2097688080 title "The importance of plasma protein binding in drug discovery" @default.
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