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• W2097688085 abstract "ABSTRACT CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents." @default.
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• W2097688085 date "2014-07-01" @default.
• W2097688085 modified "2023-10-16" @default.
• W2097688085 title "New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent" @default.
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• W2097688085 doi "https://doi.org/10.1128/aac.02600-14" @default.
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