Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097693778> ?p ?o ?g. }
- W2097693778 endingPage "755" @default.
- W2097693778 startingPage "742" @default.
- W2097693778 abstract "Since the N-methyl-D-aspartate receptor (NMDAR) subunits were cloned less than two decades ago, a substantial amount of research has been invested into understanding their physiological function in the healthy CNS. Research has also been directed at their pathological roles in various neurological diseases, including disorders resulting from acute excitotoxic insults (eg, ischaemic stroke, traumatic brain injury), diseases due to chronic neurodegeneration (eg, Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis), disorders arising from sensitisation of neurons (eg, epilepsy, neuropathic pain), and neurodevelopmental disorders associated with NMDAR hypofunction (eg, schizophrenia). Selective NMDAR antagonists have not produced positive results in clinical trials. However, there are other NMDAR-targeted therapies used in current practice that are effective for treating some neurological disorders. In this Review, we describe the evidence for the use of these therapies and provide an overview of drugs being investigated in clinical trials. We also discuss new NMDAR-targeted strategies in clinical neurology." @default.
- W2097693778 created "2016-06-24" @default.
- W2097693778 creator A5033165479 @default.
- W2097693778 creator A5077133037 @default.
- W2097693778 creator A5079156379 @default.
- W2097693778 date "2008-08-01" @default.
- W2097693778 modified "2023-09-23" @default.
- W2097693778 title "NMDA receptors in clinical neurology: excitatory times ahead" @default.
- W2097693778 cites W1494210462 @default.
- W2097693778 cites W1506357578 @default.
- W2097693778 cites W1532214820 @default.
- W2097693778 cites W1532904557 @default.
- W2097693778 cites W1559213768 @default.
- W2097693778 cites W1575571855 @default.
- W2097693778 cites W1575637711 @default.
- W2097693778 cites W1695543549 @default.
- W2097693778 cites W1884366104 @default.
- W2097693778 cites W1962254068 @default.
- W2097693778 cites W1965185022 @default.
- W2097693778 cites W1966247331 @default.
- W2097693778 cites W1968073713 @default.
- W2097693778 cites W1972788353 @default.
- W2097693778 cites W1973116987 @default.
- W2097693778 cites W1974720828 @default.
- W2097693778 cites W1975239250 @default.
- W2097693778 cites W1975944686 @default.
- W2097693778 cites W1975975999 @default.
- W2097693778 cites W1976645888 @default.
- W2097693778 cites W1976899878 @default.
- W2097693778 cites W1978710583 @default.
- W2097693778 cites W1980916056 @default.
- W2097693778 cites W1984170477 @default.
- W2097693778 cites W1985456422 @default.
- W2097693778 cites W1986710440 @default.
- W2097693778 cites W1987885389 @default.
- W2097693778 cites W1990057142 @default.
- W2097693778 cites W1991023452 @default.
- W2097693778 cites W1992177920 @default.
- W2097693778 cites W1992469827 @default.
- W2097693778 cites W1995396359 @default.
- W2097693778 cites W1995776925 @default.
- W2097693778 cites W1996884974 @default.
- W2097693778 cites W1999374340 @default.
- W2097693778 cites W2001893348 @default.
- W2097693778 cites W2007037518 @default.
- W2097693778 cites W2008639041 @default.
- W2097693778 cites W2009023836 @default.
- W2097693778 cites W2009297217 @default.
- W2097693778 cites W2012641732 @default.
- W2097693778 cites W2014086428 @default.
- W2097693778 cites W2015342345 @default.
- W2097693778 cites W2015594730 @default.
- W2097693778 cites W2017603013 @default.
- W2097693778 cites W2019628762 @default.
- W2097693778 cites W2022317515 @default.
- W2097693778 cites W2023243943 @default.
- W2097693778 cites W2025931796 @default.
- W2097693778 cites W2026084202 @default.
- W2097693778 cites W2029922642 @default.
- W2097693778 cites W2030672678 @default.
- W2097693778 cites W2030756376 @default.
- W2097693778 cites W2037587486 @default.
- W2097693778 cites W2038226090 @default.
- W2097693778 cites W2040461899 @default.
- W2097693778 cites W2041371057 @default.
- W2097693778 cites W2053442326 @default.
- W2097693778 cites W2053980736 @default.
- W2097693778 cites W2054447736 @default.
- W2097693778 cites W2055381303 @default.
- W2097693778 cites W2058112065 @default.
- W2097693778 cites W2059334396 @default.
- W2097693778 cites W2063541383 @default.
- W2097693778 cites W2063661531 @default.
- W2097693778 cites W2067457311 @default.
- W2097693778 cites W2069314031 @default.
- W2097693778 cites W2073486423 @default.
- W2097693778 cites W2074020222 @default.
- W2097693778 cites W2081070804 @default.
- W2097693778 cites W2083067786 @default.
- W2097693778 cites W2083204774 @default.
- W2097693778 cites W2083969921 @default.
- W2097693778 cites W2085165928 @default.
- W2097693778 cites W2092356280 @default.
- W2097693778 cites W2095011021 @default.
- W2097693778 cites W2095868750 @default.
- W2097693778 cites W2097095684 @default.
- W2097693778 cites W2099970570 @default.
- W2097693778 cites W2110350185 @default.
- W2097693778 cites W2117455848 @default.
- W2097693778 cites W2117745130 @default.
- W2097693778 cites W2121402661 @default.
- W2097693778 cites W2121928725 @default.
- W2097693778 cites W2122804584 @default.
- W2097693778 cites W2122863606 @default.
- W2097693778 cites W2123636141 @default.
- W2097693778 cites W2123779560 @default.
- W2097693778 cites W2124279185 @default.
- W2097693778 cites W2124867876 @default.