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- W2097698181 abstract "Although hepatitis B vaccine reliably induces immunity to hepatitis B virus, the expense of intramuscular (im) vaccination with this product has limited its use. To determine if a smaller, less expensive, intradermal (id) dose of hepatitis B vaccine would be an effective alternative, we compared the response of antibody to hepatitis B surface antigen (anti-HBs) following im vaccination to that following id vaccination. Volunteers who were seronegative for antibody to hepatitis B core antigen were enrolled in the study and received either im or id vaccine. A total of 108 subjects received three 1-mL im injections of hepatitis B vaccine, and another 110 subjects received four 0.1-mL id injections of the vaccine. Similar rates of seroconversion occurred; greater than or equal to 10 mIU of anti-HBs/mL was noted following either three im or three id vaccinations. Furthermore, 2 years after initiation of vaccination, the serum concentration of anti-HBs for id vaccine recipients was similar to that for im vaccine recipients." @default.
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- W2097698181 date "1990-11-01" @default.
- W2097698181 modified "2023-09-25" @default.
- W2097698181 title "Comparison of the Immunogenicity of Hepatitis B Vaccine Administered Intradermally and Intramuscularly" @default.
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- W2097698181 doi "https://doi.org/10.1093/clinids/12.6.1035" @default.
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