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• W2097699864 abstract "Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA2 appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA2 in a large population-based cohort and to determine associations between Lp-PLA2 and other risk factors for CVD. The study group consisted of participants from the Malmö Diet and Cancer study (1992–1994). Lp-PLA2 (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA2 activity and mass in this study (r = 0.57). Highest correlations were observed between Lp-PLA2 activity and LDL (r = 0.45) and LDL/HDL ratio (r = 0.54) and a strong inverse correlation to HDL (r = −0.31). The correlations between Lp-PLA2 mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA2 activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA2 is strongly correlated with several cardiovascular risk factors, especially lipid fractions, and with the degree of carotid artery atherosclerosis. However, the measured variables accounted for only 19% and 35% of the variation in Lp-PLA2 mass and activity respectively." @default.
• W2097699864 created "2016-06-24" @default.
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• W2097699864 date "2007-02-01" @default.
• W2097699864 modified "2023-10-17" @default.
• W2097699864 title "The epidemiology of Lp-PLA2: Distribution and correlation with cardiovascular risk factors in a population-based cohort" @default.
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• W2097699864 doi "https://doi.org/10.1016/j.atherosclerosis.2006.02.016" @default.
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