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- W2097699993 abstract "Although CHOP (cyclophosphamide/ vincristine/doxorubicin/prednisone) is the standard of care for patients with aggressive non-Hodgkin’s lymphomas (NHL), CHOP has a cure rate of less than 40% in patients with advanced disease.1 In an effort to improve this cure rate, rituximab has been combined with CHOP chemotherapy in patients with diffuse large B-cell lymphoma (DLBCL). The combination of rituximab with CHOP is supported by preclinical data that suggest that synergistic interactions exist between doxorubicin and rituximab2; rituximab’s encouraging efficacy as a single agent in patients with aggressive NHL, its differing mechanisms of action, and its nonoverlapping toxicity profile also support this combination. In a phase II trial, rituximab/CHOP was shown to yield a complete remission in 61% of 33 patients with chemotherapy-naive aggressive NHL.3 Moreover, 29 of the 31 patients who achieved an objective response remained in remission for a median follow-up time of 26 months. The French Groupe d’Etudes des Lymphomes de l’Adulte (GELA) have undertaken a randomized phase III trial comparing rituximab/ CHOP to CHOP alone in elderly patients with chemotherapy-naive DLBCL. The results of a planned interim analysis on the first 328 patients was initially presented at the plenary session of the 2000 American Society of Hematology (ASH) Meeting held in San Francisco, California.4 The updated results, at 19 months of follow-up, were presented at the 2001 European Hematology Association (EHA) Meeting held in Frankfurt, Germany.5 This trial enrolled patients who were 60-80 years of age with stage II, III, or IV diffuse large-cell lymphoma and an Eastern Cooperative Oncology Group (ECOG) performance status (PS) between 0 and 2. Patients were randomized to treatHighlights prepared by Kavita Maung, PhD and Amy I. D’Orazio, PhD Reviewed by Bruce D. Cheson, MD and Vinay K. Jain, MD 6th European Hematology Association Meeting Frankfurt, Germany June 21-24, 2001 Highlights Meeting" @default.
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- W2097699993 date "2001-09-01" @default.
- W2097699993 modified "2023-09-25" @default.
- W2097699993 title "Highlights From: 6th European Hematology Association Meeting, Frankfurt, Germany June 21–24, 2001" @default.
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- W2097699993 doi "https://doi.org/10.1016/s1526-9655(11)70132-4" @default.
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