Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097718744> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2097718744 endingPage "H31" @default.
- W2097718744 startingPage "H24" @default.
- W2097718744 abstract "Tadalafil, a potent, selective and reversible inhibitor of phosphodiesterase type 5 that is under review as an oral therapy for erectile dysfunction, has a time to maximum concentration of 2h and a half-life of 17·5 h. Systemic tadalafil exposure was not clinically significantly altered by age or diabetes. Food did not alter the rate and extent of absorption of tadalafil, and no restrictions regarding food or alcohol intake were imposed on patients in tadalafil clinical trials. Furthermore, the time of dosing had no significant effect on the systemic distribution of tadalafil. Integrated analyses of data from five phase III trials demonstrated that tadalafil at doses from 5m g to 20 mg significantly improved erectile function (vs placebo) by all efficacy measures. Tadalafil was safe and well tolerated in the phase III studies, with headache and dyspepsia being the most frequent adverse events. Additionally, in a separate study of patients with erectile dysfunction and diabetes, tadalafil 10 mg and 20 mg significantly improved all efficacy measures as compared with placebo. (Eur Heart J Supplements 2002; 4 (Suppl H): H24‐H31)" @default.
- W2097718744 created "2016-06-24" @default.
- W2097718744 creator A5048400506 @default.
- W2097718744 date "2002-12-01" @default.
- W2097718744 modified "2023-10-14" @default.
- W2097718744 title "Tadalafil: a novel treatment for erectile dysfunction" @default.
- W2097718744 cites W1209101840 @default.
- W2097718744 cites W1779484613 @default.
- W2097718744 cites W1967587373 @default.
- W2097718744 cites W1970134738 @default.
- W2097718744 cites W1974490933 @default.
- W2097718744 cites W2006457199 @default.
- W2097718744 cites W2009639166 @default.
- W2097718744 cites W2010379871 @default.
- W2097718744 cites W2011671805 @default.
- W2097718744 cites W2028971791 @default.
- W2097718744 cites W2056147576 @default.
- W2097718744 cites W2064160275 @default.
- W2097718744 cites W2068913937 @default.
- W2097718744 cites W2070663317 @default.
- W2097718744 cites W2086240335 @default.
- W2097718744 cites W2099112709 @default.
- W2097718744 cites W2121939064 @default.
- W2097718744 cites W2152740713 @default.
- W2097718744 cites W2164189667 @default.
- W2097718744 cites W2170259285 @default.
- W2097718744 cites W2406062456 @default.
- W2097718744 cites W2254928527 @default.
- W2097718744 doi "https://doi.org/10.1016/s1520-765x(02)90049-0" @default.
- W2097718744 hasPublicationYear "2002" @default.
- W2097718744 type Work @default.
- W2097718744 sameAs 2097718744 @default.
- W2097718744 citedByCount "18" @default.
- W2097718744 countsByYear W20977187442014 @default.
- W2097718744 countsByYear W20977187442020 @default.
- W2097718744 countsByYear W20977187442022 @default.
- W2097718744 crossrefType "journal-article" @default.
- W2097718744 hasAuthorship W2097718744A5048400506 @default.
- W2097718744 hasBestOaLocation W20977187441 @default.
- W2097718744 hasConcept C126322002 @default.
- W2097718744 hasConcept C126894567 @default.
- W2097718744 hasConcept C2779929075 @default.
- W2097718744 hasConcept C2780816001 @default.
- W2097718744 hasConcept C29456083 @default.
- W2097718744 hasConcept C71924100 @default.
- W2097718744 hasConceptScore W2097718744C126322002 @default.
- W2097718744 hasConceptScore W2097718744C126894567 @default.
- W2097718744 hasConceptScore W2097718744C2779929075 @default.
- W2097718744 hasConceptScore W2097718744C2780816001 @default.
- W2097718744 hasConceptScore W2097718744C29456083 @default.
- W2097718744 hasConceptScore W2097718744C71924100 @default.
- W2097718744 hasLocation W20977187441 @default.
- W2097718744 hasOpenAccess W2097718744 @default.
- W2097718744 hasPrimaryLocation W20977187441 @default.
- W2097718744 hasRelatedWork W2036680573 @default.
- W2097718744 hasRelatedWork W2039928740 @default.
- W2097718744 hasRelatedWork W2322037458 @default.
- W2097718744 hasRelatedWork W2462412454 @default.
- W2097718744 hasRelatedWork W2563802859 @default.
- W2097718744 hasRelatedWork W2803508630 @default.
- W2097718744 hasRelatedWork W2973145583 @default.
- W2097718744 hasRelatedWork W3004280094 @default.
- W2097718744 hasRelatedWork W4234738469 @default.
- W2097718744 hasRelatedWork W4238070260 @default.
- W2097718744 hasVolume "4" @default.
- W2097718744 isParatext "false" @default.
- W2097718744 isRetracted "false" @default.
- W2097718744 magId "2097718744" @default.
- W2097718744 workType "article" @default.