FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097724071> ?p ?o ?g. }

• W2097724071 endingPage "3976" @default.
• W2097724071 startingPage "3961" @default.
• W2097724071 abstract "pQDLDHVFLRFamide is a highly conserved crustacean neuropeptide with a structure that places it within the myosuppressin subfamily of the FMRFamide-like peptides. Despite its apparent ubiquitous conservation in decapod crustaceans, the paracrine and/or endocrine roles played by pQDLDHVFLRFamide remain largely unknown. We have examined the actions of this peptide on the cardiac neuromuscular system of the American lobster Homarus americanus using four preparations: the intact animal, the heart in vitro, the isolated cardiac ganglion (CG), and a stimulated heart muscle preparation. In the intact animal, injection of myosuppressin caused a decrease in heartbeat frequency. Perfusion of the in vitro heart with pQDLDHVFLRFamide elicited a decrease in the frequency and an increase in the amplitude of heart contractions. In the isolated CG, myosuppressin induced a hyperpolarization of the resting membrane potential of cardiac motor neurons and a decrease in the cycle frequency of their bursting. In the stimulated heart muscle preparation, pQDLDHVFLRFamide increased the amplitude of the induced contractions, suggesting that myosuppressin modulates not only the CG, but also peripheral sites. For at least the in vitro heart and the isolated CG, the effects of myosuppressin were dose-dependent (10(-9) to 10(-6) mol l(-1) tested), with threshold concentrations (10(-8)-10(-7) mol l(-1)) consistent with the peptide serving as a circulating hormone. Although cycle frequency, a parameter directly determined by the CG, consistently decreased when pQDLDHVFLRFamide was applied to all preparation types, the magnitudes of this decrease differed, suggesting the possibility that, because myosuppressin modulates the CG and the periphery, it also alters peripheral feedback to the CG." @default.
• W2097724071 created "2016-06-24" @default.
• W2097724071 creator A5010897515 @default.
• W2097724071 creator A5013979838 @default.
• W2097724071 creator A5030009571 @default.
• W2097724071 creator A5033244653 @default.
• W2097724071 creator A5041566236 @default.
• W2097724071 creator A5057881385 @default.
• W2097724071 creator A5068678816 @default.
• W2097724071 date "2009-12-15" @default.
• W2097724071 modified "2023-10-14" @default.
• W2097724071 title "The peptide hormone pQDLDHVFLRFamide (crustacean myosuppressin) modulates the<i>Homarus americanus</i>cardiac neuromuscular system at multiple sites" @default.
• W2097724071 cites W1493165571 @default.
• W2097724071 cites W1520357143 @default.
• W2097724071 cites W1542384815 @default.
• W2097724071 cites W1598191619 @default.
• W2097724071 cites W1840762561 @default.
• W2097724071 cites W1843055873 @default.
• W2097724071 cites W1892973125 @default.
• W2097724071 cites W1907426068 @default.
• W2097724071 cites W1963831743 @default.
• W2097724071 cites W1964062151 @default.
• W2097724071 cites W1968341755 @default.
• W2097724071 cites W1968612010 @default.
• W2097724071 cites W1971846732 @default.
• W2097724071 cites W1971941341 @default.
• W2097724071 cites W1976341503 @default.
• W2097724071 cites W1980286821 @default.
• W2097724071 cites W1983013207 @default.
• W2097724071 cites W1986893059 @default.
• W2097724071 cites W1995545258 @default.
• W2097724071 cites W2002604064 @default.
• W2097724071 cites W2003126951 @default.
• W2097724071 cites W2014480237 @default.
• W2097724071 cites W2028317058 @default.
• W2097724071 cites W2028438413 @default.
• W2097724071 cites W2038203428 @default.
• W2097724071 cites W2052363451 @default.
• W2097724071 cites W2053498848 @default.
• W2097724071 cites W2059306536 @default.
• W2097724071 cites W2059341808 @default.
• W2097724071 cites W2062343322 @default.
• W2097724071 cites W2062976536 @default.
• W2097724071 cites W2079261637 @default.
• W2097724071 cites W2079839478 @default.
• W2097724071 cites W2082330408 @default.
• W2097724071 cites W2082478638 @default.
• W2097724071 cites W2083290871 @default.
• W2097724071 cites W2089217335 @default.
• W2097724071 cites W2089341697 @default.
• W2097724071 cites W2092765533 @default.
• W2097724071 cites W2100833336 @default.
• W2097724071 cites W2105416702 @default.
• W2097724071 cites W2106437587 @default.
• W2097724071 cites W2106452753 @default.
• W2097724071 cites W2111854851 @default.
• W2097724071 cites W2114976321 @default.
• W2097724071 cites W2121305031 @default.
• W2097724071 cites W2126541983 @default.
• W2097724071 cites W2126570355 @default.
• W2097724071 cites W2126724209 @default.
• W2097724071 cites W2130120547 @default.
• W2097724071 cites W2134346308 @default.
• W2097724071 cites W2137918188 @default.
• W2097724071 cites W2143953618 @default.
• W2097724071 cites W2155981340 @default.
• W2097724071 cites W2156880797 @default.
• W2097724071 cites W2158714788 @default.
• W2097724071 cites W2161746138 @default.
• W2097724071 cites W2167266299 @default.
• W2097724071 cites W2168964292 @default.
• W2097724071 cites W2184838500 @default.
• W2097724071 cites W2187895382 @default.
• W2097724071 cites W2188999009 @default.
• W2097724071 cites W2225167171 @default.
• W2097724071 cites W2247772332 @default.
• W2097724071 cites W2321773098 @default.
• W2097724071 cites W2329057098 @default.
• W2097724071 cites W2395633225 @default.
• W2097724071 cites W2406274647 @default.
• W2097724071 cites W2409904417 @default.
• W2097724071 cites W2414057263 @default.
• W2097724071 cites W2418801758 @default.
• W2097724071 cites W2495025554 @default.
• W2097724071 cites W81087735 @default.
• W2097724071 doi "https://doi.org/10.1242/jeb.035741" @default.
• W2097724071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2784736" @default.
• W2097724071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19946074" @default.
• W2097724071 hasPublicationYear "2009" @default.
• W2097724071 type Work @default.
• W2097724071 sameAs 2097724071 @default.
• W2097724071 citedByCount "53" @default.
• W2097724071 countsByYear W20977240712012 @default.
• W2097724071 countsByYear W20977240712013 @default.
• W2097724071 countsByYear W20977240712014 @default.
• W2097724071 countsByYear W20977240712015 @default.
• W2097724071 countsByYear W20977240712016 @default.
• W2097724071 countsByYear W20977240712017 @default.

• next