FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097737551> ?p ?o ?g. }

• W2097737551 endingPage "11410" @default.
• W2097737551 startingPage "11395" @default.
• W2097737551 abstract "Monocytic cells, including macrophages and dendritic cells, exist in different activation states that are critical to the regulation of antimicrobial immunity. Many pandemic viruses are monocytotropic, including porcine reproductive and respiratory syndrome virus (PRRSV), which directly infects subsets of monocytic cells and interferes with antiviral responses. To study antiviral responses in PRRSV-infected monocytic cells, we characterized inflammatory cytokine responses and genome-wide profiled signature genes to investigate response pathways in uninfected and PRRSV-infected monocytic cells at different activation states. Our findings showed suppressed interferon (IFN) production in macrophages in non-antiviral states and an arrest of lipid metabolic pathways in macrophages at antiviral states. Importantly, porcine monocytic cells at different activation states were susceptible to PRRSV and responded differently to viral infection. Based on Gene Ontology (GO) analysis, two approaches were used to potentiate antiviral activity: (i) pharmaceutical modulation of cellular lipid metabolism and (ii) in situ PRRSV replication-competent expression of interferon alpha (IFN-α). Both approaches significantly suppressed exogenous viral infection in monocytic cells. In particular, the engineered IFN-expressing PRRSV strain eliminated exogenous virus infection and sustained cell viability at 4 days postinfection in macrophages. These findings suggest an intricate interaction of viral infection with the activation status of porcine monocytic cells. An understanding and integration of antiviral infection with activation status of monocytic cells may provide a means of potentiating antiviral immunity.Activation statuses of monocytic cells, including monocytes, macrophages (Mϕs), and dendritic cells (DCs), are critically important for antiviral immunity. Unfortunately, the activation status of porcine monocytic cells or how cell activation status functionally interacts with antiviral immunity remains largely unknown. This is a significant omission because many economically important porcine viruses are monocytotropic, including our focus, PRRSV, which alone causes nearly $800 million economic loss annually in the U.S. swine industries. PRRSV is ideal for deciphering how monocytic cell activation statuses interact with antiviral immunity, because it directly infects subsets of monocytic cells and subverts overall immune responses. In this study, we systematically investigate the activation status of porcine monocytic cells to determine the intricate interaction of viral infection with activation statuses and functionally regulate antiviral immunity within the framework of the activation paradigm. Our findings may provide a means of potentiating antiviral immunity and leading to novel vaccines for PRRS prevention." @default.
• W2097737551 created "2016-06-24" @default.
• W2097737551 creator A5001856734 @default.
• W2097737551 creator A5024807109 @default.
• W2097737551 creator A5075288916 @default.
• W2097737551 date "2014-10-01" @default.
• W2097737551 modified "2023-10-02" @default.
• W2097737551 title "Antiviral Regulation in Porcine Monocytic Cells at Different Activation States" @default.
• W2097737551 cites W135539280 @default.
• W2097737551 cites W153263572 @default.
• W2097737551 cites W1900874324 @default.
• W2097737551 cites W1964271390 @default.
• W2097737551 cites W1966202269 @default.
• W2097737551 cites W1968038394 @default.
• W2097737551 cites W1978961805 @default.
• W2097737551 cites W1979449955 @default.
• W2097737551 cites W1983921453 @default.
• W2097737551 cites W1992974015 @default.
• W2097737551 cites W1996799820 @default.
• W2097737551 cites W2010144596 @default.
• W2097737551 cites W2013510722 @default.
• W2097737551 cites W2016957221 @default.
• W2097737551 cites W2017650984 @default.
• W2097737551 cites W2018814624 @default.
• W2097737551 cites W2020744745 @default.
• W2097737551 cites W2023275569 @default.
• W2097737551 cites W2025031008 @default.
• W2097737551 cites W2025300443 @default.
• W2097737551 cites W2025648442 @default.
• W2097737551 cites W2028713402 @default.
• W2097737551 cites W2035509260 @default.
• W2097737551 cites W2038139581 @default.
• W2097737551 cites W2051665875 @default.
• W2097737551 cites W2053664831 @default.
• W2097737551 cites W2054472394 @default.
• W2097737551 cites W2056400914 @default.
• W2097737551 cites W2061546617 @default.
• W2097737551 cites W2065054791 @default.
• W2097737551 cites W2065210647 @default.
• W2097737551 cites W2065794552 @default.
• W2097737551 cites W2067074320 @default.
• W2097737551 cites W2072517432 @default.
• W2097737551 cites W2073008636 @default.
• W2097737551 cites W2078450673 @default.
• W2097737551 cites W2080658428 @default.
• W2097737551 cites W2086858987 @default.
• W2097737551 cites W2088011208 @default.
• W2097737551 cites W2098091403 @default.
• W2097737551 cites W2100820895 @default.
• W2097737551 cites W2106638391 @default.
• W2097737551 cites W2106684817 @default.
• W2097737551 cites W2114104545 @default.
• W2097737551 cites W2124500668 @default.
• W2097737551 cites W2125279845 @default.
• W2097737551 cites W2126510926 @default.
• W2097737551 cites W2133466926 @default.
• W2097737551 cites W2135730659 @default.
• W2097737551 cites W2141628481 @default.
• W2097737551 cites W2142581353 @default.
• W2097737551 cites W2143368483 @default.
• W2097737551 cites W2144485355 @default.
• W2097737551 cites W2146302858 @default.
• W2097737551 cites W2159972578 @default.
• W2097737551 cites W2161834691 @default.
• W2097737551 cites W2168404238 @default.
• W2097737551 cites W2170938141 @default.
• W2097737551 cites W4361866506 @default.
• W2097737551 cites W2098751820 @default.
• W2097737551 doi "https://doi.org/10.1128/jvi.01714-14" @default.
• W2097737551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4178830" @default.
• W2097737551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25056886" @default.
• W2097737551 hasPublicationYear "2014" @default.
• W2097737551 type Work @default.
• W2097737551 sameAs 2097737551 @default.
• W2097737551 citedByCount "31" @default.
• W2097737551 countsByYear W20977375512014 @default.
• W2097737551 countsByYear W20977375512015 @default.
• W2097737551 countsByYear W20977375512016 @default.
• W2097737551 countsByYear W20977375512017 @default.
• W2097737551 countsByYear W20977375512018 @default.
• W2097737551 countsByYear W20977375512019 @default.
• W2097737551 countsByYear W20977375512020 @default.
• W2097737551 countsByYear W20977375512021 @default.
• W2097737551 countsByYear W20977375512022 @default.
• W2097737551 countsByYear W20977375512023 @default.
• W2097737551 crossrefType "journal-article" @default.
• W2097737551 hasAuthorship W2097737551A5001856734 @default.
• W2097737551 hasAuthorship W2097737551A5024807109 @default.
• W2097737551 hasAuthorship W2097737551A5075288916 @default.
• W2097737551 hasBestOaLocation W20977375511 @default.
• W2097737551 hasConcept C136449434 @default.
• W2097737551 hasConcept C140704245 @default.
• W2097737551 hasConcept C159047783 @default.
• W2097737551 hasConcept C202751555 @default.
• W2097737551 hasConcept C203014093 @default.
• W2097737551 hasConcept C2522874641 @default.
• W2097737551 hasConcept C2776178377 @default.
• W2097737551 hasConcept C2779244956 @default.

• next