FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097757788> ?p ?o ?g. }

• W2097757788 endingPage "174" @default.
• W2097757788 startingPage "163" @default.
• W2097757788 abstract "Steroid hormone biosynthesis in the adrenal cortex is controlled by the peptide hormone adrenocorticotropin (ACTH), which acts to increase intracellular cAMP and results in the activation of cAMP-dependent protein kinase A (PKA) and subsequent increase in steroidogenic gene transcription. Protein phosphorylation by PKA activates transcription of genes encoding steroidogenic enzymes; however the precise proteins which are phosphorylated remain to be determined. We have recently shown that phosphoprotein phosphatase (PP) activity is essential for cAMP-dependent transcription of the human CYP17 (hCYP17) gene in H295R adrenocortical cells. The aim of our current studies was to determine if inhibition of PP activity attenuates cAMP-dependent mRNA expression of other steroidogenic genes in H295R cells. Using various inhibitors of serine/threonine and tyrosine PPs, we examined the role of phosphatase activity on cAMP-dependent transcription of steroidogenic genes in the adrenal cortex. CYP11A, CYP11B1/2, CYP21, and adrenodoxin also require PP activity for cAMP-stimulated gene expression. Inhibition of both serine/threonine and tyrosine PP activities suppresses the cAMP-dependent mRNA expression of several steroidogenic genes, suggesting that a dual-specificity PP is essential for conveying ACTH/cAMP-stimulated transcription. We propose that PKA phosphorylates and activates a dual-specificity phosphatase, which mediates steroidogenic gene transcription in response to ACTH/cAMP." @default.
• W2097757788 created "2016-06-24" @default.
• W2097757788 creator A5051646679 @default.
• W2097757788 creator A5065059101 @default.
• W2097757788 date "2002-08-01" @default.
• W2097757788 modified "2023-10-16" @default.
• W2097757788 title "cAMP-dependent transcription of steroidogenic genes in the human adrenal cortex requires a dual-specificity phosphatase in addition to protein kinase A" @default.
• W2097757788 cites W1533192527 @default.
• W2097757788 cites W1545133530 @default.
• W2097757788 cites W1559780175 @default.
• W2097757788 cites W1573255988 @default.
• W2097757788 cites W1601300393 @default.
• W2097757788 cites W1773661406 @default.
• W2097757788 cites W1968474526 @default.
• W2097757788 cites W1984912857 @default.
• W2097757788 cites W1988492071 @default.
• W2097757788 cites W2001293789 @default.
• W2097757788 cites W2020184457 @default.
• W2097757788 cites W2025452617 @default.
• W2097757788 cites W2027277658 @default.
• W2097757788 cites W2028642327 @default.
• W2097757788 cites W2036831868 @default.
• W2097757788 cites W2048796957 @default.
• W2097757788 cites W2050144502 @default.
• W2097757788 cites W2057441124 @default.
• W2097757788 cites W2061806445 @default.
• W2097757788 cites W2061933315 @default.
• W2097757788 cites W2067930732 @default.
• W2097757788 cites W2069979341 @default.
• W2097757788 cites W2073763063 @default.
• W2097757788 cites W2080449344 @default.
• W2097757788 cites W2083800765 @default.
• W2097757788 cites W2086178662 @default.
• W2097757788 cites W2090695896 @default.
• W2097757788 cites W2104512123 @default.
• W2097757788 cites W2111305451 @default.
• W2097757788 cites W2137221055 @default.
• W2097757788 cites W2144634347 @default.
• W2097757788 cites W2334323026 @default.
• W2097757788 cites W2468473882 @default.
• W2097757788 cites W63593463 @default.
• W2097757788 doi "https://doi.org/10.1677/jme.0.0290163" @default.
• W2097757788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12200237" @default.
• W2097757788 hasPublicationYear "2002" @default.
• W2097757788 type Work @default.
• W2097757788 sameAs 2097757788 @default.
• W2097757788 citedByCount "44" @default.
• W2097757788 countsByYear W20977577882012 @default.
• W2097757788 countsByYear W20977577882013 @default.
• W2097757788 countsByYear W20977577882014 @default.
• W2097757788 countsByYear W20977577882015 @default.
• W2097757788 countsByYear W20977577882016 @default.
• W2097757788 countsByYear W20977577882017 @default.
• W2097757788 countsByYear W20977577882018 @default.
• W2097757788 countsByYear W20977577882019 @default.
• W2097757788 countsByYear W20977577882020 @default.
• W2097757788 countsByYear W20977577882022 @default.
• W2097757788 crossrefType "journal-article" @default.
• W2097757788 hasAuthorship W2097757788A5051646679 @default.
• W2097757788 hasAuthorship W2097757788A5065059101 @default.
• W2097757788 hasBestOaLocation W20977577881 @default.
• W2097757788 hasConcept C101762097 @default.
• W2097757788 hasConcept C104317684 @default.
• W2097757788 hasConcept C11960822 @default.
• W2097757788 hasConcept C150194340 @default.
• W2097757788 hasConcept C153911025 @default.
• W2097757788 hasConcept C185592680 @default.
• W2097757788 hasConcept C2777703421 @default.
• W2097757788 hasConcept C2777977426 @default.
• W2097757788 hasConcept C55493867 @default.
• W2097757788 hasConcept C63932345 @default.
• W2097757788 hasConcept C86339819 @default.
• W2097757788 hasConcept C86803240 @default.
• W2097757788 hasConcept C95444343 @default.
• W2097757788 hasConcept C97029542 @default.
• W2097757788 hasConceptScore W2097757788C101762097 @default.
• W2097757788 hasConceptScore W2097757788C104317684 @default.
• W2097757788 hasConceptScore W2097757788C11960822 @default.
• W2097757788 hasConceptScore W2097757788C150194340 @default.
• W2097757788 hasConceptScore W2097757788C153911025 @default.
• W2097757788 hasConceptScore W2097757788C185592680 @default.
• W2097757788 hasConceptScore W2097757788C2777703421 @default.
• W2097757788 hasConceptScore W2097757788C2777977426 @default.
• W2097757788 hasConceptScore W2097757788C55493867 @default.
• W2097757788 hasConceptScore W2097757788C63932345 @default.
• W2097757788 hasConceptScore W2097757788C86339819 @default.
• W2097757788 hasConceptScore W2097757788C86803240 @default.
• W2097757788 hasConceptScore W2097757788C95444343 @default.
• W2097757788 hasConceptScore W2097757788C97029542 @default.
• W2097757788 hasIssue "1" @default.
• W2097757788 hasLocation W20977577881 @default.
• W2097757788 hasLocation W20977577882 @default.
• W2097757788 hasOpenAccess W2097757788 @default.
• W2097757788 hasPrimaryLocation W20977577881 @default.
• W2097757788 hasRelatedWork W1576705593 @default.
• W2097757788 hasRelatedWork W1971547524 @default.
• W2097757788 hasRelatedWork W1975811142 @default.
• W2097757788 hasRelatedWork W2009966535 @default.

• next