FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097777166> ?p ?o ?g. }

• W2097777166 endingPage "792" @default.
• W2097777166 startingPage "788" @default.
• W2097777166 abstract "Some researchs have demonstrated that the loss of delta Np63 is associated with aggressive phenotypes and poor prognosis. However, other research indicates that delta Np63 is considered to have oncogenic properties. Delta Np63 overexpression is often observed in association with the oncogenic growth of squamous cell carcinomas and bladder cancer. In this study, we investigated the oncogenic role of delta Np63 in regulating cell adhesion in transitional cell carcinoma of the bladder (TCCB). The cells were stably transfected with the delta Np63 short hairpin RNA (shRNA) plasmid. Immunocytochemistry was performed to determine the knockdown efficiency. Tumour cells were studied for their ability to adhere to vascular endothelial cells. Confocal microscopy was used to analyse the changes in cytoskeletal F-actin. F-actin expression was measured by flow cytometry. Cell invasion ability was assessed using transwell chambers. The delta Np63-silenced tumour cells were shown to adhere more tightly than controls to vascular endothelial cells (P<0.05). The content of F-actin in the delta Np63-silenced cells was enhanced (P<0.05). The Matrigel invasion assays showed that human 5637 bladder cancer cells had a lower degree of motility when transfected with pdelta Np63-shRNA (P<0.05). In conclusion, silencing of the delta Np63 expression can enhance the adhesiveness of 5637 cells by inducing F-actin cytoskeleton production, and it will possibly inhibit the TCCB invasion and metastasis." @default.
• W2097777166 created "2016-06-24" @default.
• W2097777166 creator A5005141695 @default.
• W2097777166 creator A5045382981 @default.
• W2097777166 creator A5048634299 @default.
• W2097777166 creator A5049876471 @default.
• W2097777166 creator A5069571261 @default.
• W2097777166 creator A5073346815 @default.
• W2097777166 creator A5077290418 @default.
• W2097777166 date "2012-08-20" @default.
• W2097777166 modified "2023-09-27" @default.
• W2097777166 title "Upregulation of cell adhesion through delta Np63 silencing in human 5637 bladder cancer cells" @default.
• W2097777166 cites W1584759442 @default.
• W2097777166 cites W1872348525 @default.
• W2097777166 cites W1965395825 @default.
• W2097777166 cites W1970961625 @default.
• W2097777166 cites W1985064409 @default.
• W2097777166 cites W2002426801 @default.
• W2097777166 cites W2014938226 @default.
• W2097777166 cites W2015926170 @default.
• W2097777166 cites W2038783205 @default.
• W2097777166 cites W2040980668 @default.
• W2097777166 cites W2048962185 @default.
• W2097777166 cites W2054273558 @default.
• W2097777166 cites W2062364714 @default.
• W2097777166 cites W2063070094 @default.
• W2097777166 cites W2067519450 @default.
• W2097777166 cites W2071733326 @default.
• W2097777166 cites W2090494026 @default.
• W2097777166 cites W2111642652 @default.
• W2097777166 cites W2135200306 @default.
• W2097777166 cites W2135977869 @default.
• W2097777166 cites W2136579137 @default.
• W2097777166 cites W2138663989 @default.
• W2097777166 cites W2148290018 @default.
• W2097777166 cites W2150507760 @default.
• W2097777166 cites W2153314392 @default.
• W2097777166 cites W2157467221 @default.
• W2097777166 cites W2158048617 @default.
• W2097777166 cites W2163549086 @default.
• W2097777166 cites W2165943742 @default.
• W2097777166 cites W2169590280 @default.
• W2097777166 cites W2169752763 @default.
• W2097777166 cites W2313786846 @default.
• W2097777166 cites W2317760542 @default.
• W2097777166 cites W244165903 @default.
• W2097777166 doi "https://doi.org/10.1038/aja.2012.42" @default.
• W2097777166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3734996" @default.
• W2097777166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22902906" @default.
• W2097777166 hasPublicationYear "2012" @default.
• W2097777166 type Work @default.
• W2097777166 sameAs 2097777166 @default.
• W2097777166 citedByCount "3" @default.
• W2097777166 countsByYear W20977771662016 @default.
• W2097777166 countsByYear W20977771662018 @default.
• W2097777166 crossrefType "journal-article" @default.
• W2097777166 hasAuthorship W2097777166A5005141695 @default.
• W2097777166 hasAuthorship W2097777166A5045382981 @default.
• W2097777166 hasAuthorship W2097777166A5048634299 @default.
• W2097777166 hasAuthorship W2097777166A5049876471 @default.
• W2097777166 hasAuthorship W2097777166A5069571261 @default.
• W2097777166 hasAuthorship W2097777166A5073346815 @default.
• W2097777166 hasAuthorship W2097777166A5077290418 @default.
• W2097777166 hasBestOaLocation W20977771661 @default.
• W2097777166 hasConcept C104317684 @default.
• W2097777166 hasConcept C119056186 @default.
• W2097777166 hasConcept C137738243 @default.
• W2097777166 hasConcept C173396325 @default.
• W2097777166 hasConcept C190232843 @default.
• W2097777166 hasConcept C2778608917 @default.
• W2097777166 hasConcept C2780394083 @default.
• W2097777166 hasConcept C502942594 @default.
• W2097777166 hasConcept C54009773 @default.
• W2097777166 hasConcept C54355233 @default.
• W2097777166 hasConcept C55493867 @default.
• W2097777166 hasConcept C81885089 @default.
• W2097777166 hasConcept C86803240 @default.
• W2097777166 hasConcept C95444343 @default.
• W2097777166 hasConceptScore W2097777166C104317684 @default.
• W2097777166 hasConceptScore W2097777166C119056186 @default.
• W2097777166 hasConceptScore W2097777166C137738243 @default.
• W2097777166 hasConceptScore W2097777166C173396325 @default.
• W2097777166 hasConceptScore W2097777166C190232843 @default.
• W2097777166 hasConceptScore W2097777166C2778608917 @default.
• W2097777166 hasConceptScore W2097777166C2780394083 @default.
• W2097777166 hasConceptScore W2097777166C502942594 @default.
• W2097777166 hasConceptScore W2097777166C54009773 @default.
• W2097777166 hasConceptScore W2097777166C54355233 @default.
• W2097777166 hasConceptScore W2097777166C55493867 @default.
• W2097777166 hasConceptScore W2097777166C81885089 @default.
• W2097777166 hasConceptScore W2097777166C86803240 @default.
• W2097777166 hasConceptScore W2097777166C95444343 @default.
• W2097777166 hasIssue "5" @default.
• W2097777166 hasLocation W20977771661 @default.
• W2097777166 hasLocation W20977771662 @default.
• W2097777166 hasLocation W20977771663 @default.
• W2097777166 hasLocation W20977771664 @default.
• W2097777166 hasOpenAccess W2097777166 @default.

• next