FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097777783> ?p ?o ?g. }

• W2097777783 endingPage "1218" @default.
• W2097777783 startingPage "1161" @default.
• W2097777783 abstract "Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the progressive degeneration of the dopaminergic neurons of the substantia nigra and is accompanied by the appearance of intraneuronal inclusions enriched in α-synuclein, the Lewy bodies. It is becoming increasingly clear that genetic factors contribute to its complex pathogenesis. Over the past decade, the genetic basis of rare PD forms with Mendelian inheritance, representing no more than 10% of the cases, has been investigated. More than 16 loci and 11 associated genes have been identified so far; genome-wide association studies have provided convincing evidence that polymorphic variants in these genes contribute to sporadic PD. The knowledge acquired of the functions of their protein products has revealed pathways of neurodegeneration that may be shared between inherited and sporadic PD. An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations. In contrast, α-synuclein accumulation in Lewy bodies defines a spectrum of disorders ranging from typical late-onset PD to PD dementia and including sporadic and autosomal dominant PD forms due to mutations in SCNA and LRRK2. However, the pathological role of Lewy bodies remains uncertain, as they may or may not be present in PD forms with one and the same LRRK2 mutation. Impairment of autophagy-based protein/organelle degradation pathways is emerging as a possible unifying but still fragile pathogenic scenario in PD. Strengthening these discoveries and finding other convergence points by identifying new genes responsible for Mendelian forms of PD and exploring their functions and relationships are the main challenges of the next decade. It is also the way to follow to open new promising avenues of neuroprotective treatment for this devastating disorder." @default.
• W2097777783 created "2016-06-24" @default.
• W2097777783 creator A5001223233 @default.
• W2097777783 creator A5027489586 @default.
• W2097777783 creator A5072972205 @default.
• W2097777783 date "2011-10-01" @default.
• W2097777783 modified "2023-10-12" @default.
• W2097777783 title "What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease" @default.
• W2097777783 cites W1481208581 @default.
• W2097777783 cites W1487645896 @default.
• W2097777783 cites W1494109356 @default.
• W2097777783 cites W1496790952 @default.
• W2097777783 cites W1502551601 @default.
• W2097777783 cites W1506873787 @default.
• W2097777783 cites W1510439895 @default.
• W2097777783 cites W1513071869 @default.
• W2097777783 cites W1514910213 @default.
• W2097777783 cites W1518778430 @default.
• W2097777783 cites W1520114760 @default.
• W2097777783 cites W1521854746 @default.
• W2097777783 cites W1527671059 @default.
• W2097777783 cites W1529474377 @default.
• W2097777783 cites W1544068927 @default.
• W2097777783 cites W1550876205 @default.
• W2097777783 cites W1572399848 @default.
• W2097777783 cites W1575974389 @default.
• W2097777783 cites W1578979732 @default.
• W2097777783 cites W1605736214 @default.
• W2097777783 cites W1618846043 @default.
• W2097777783 cites W1630502818 @default.
• W2097777783 cites W1877873625 @default.
• W2097777783 cites W1965398181 @default.
• W2097777783 cites W1965778124 @default.
• W2097777783 cites W1967361555 @default.
• W2097777783 cites W1967542661 @default.
• W2097777783 cites W1967603366 @default.
• W2097777783 cites W1968287155 @default.
• W2097777783 cites W1968785850 @default.
• W2097777783 cites W1969300701 @default.
• W2097777783 cites W1969611978 @default.
• W2097777783 cites W1969800514 @default.
• W2097777783 cites W1970386264 @default.
• W2097777783 cites W1970687029 @default.
• W2097777783 cites W1970848642 @default.
• W2097777783 cites W1971064755 @default.
• W2097777783 cites W1971144940 @default.
• W2097777783 cites W1971145588 @default.
• W2097777783 cites W1972333969 @default.
• W2097777783 cites W1972626651 @default.
• W2097777783 cites W1972939055 @default.
• W2097777783 cites W1973007531 @default.
• W2097777783 cites W1973778908 @default.
• W2097777783 cites W1974008939 @default.
• W2097777783 cites W1974150565 @default.
• W2097777783 cites W1974495051 @default.
• W2097777783 cites W1975182221 @default.
• W2097777783 cites W1975594363 @default.
• W2097777783 cites W1976316003 @default.
• W2097777783 cites W1976345822 @default.
• W2097777783 cites W1976645698 @default.
• W2097777783 cites W1976749972 @default.
• W2097777783 cites W1977166619 @default.
• W2097777783 cites W1977300363 @default.
• W2097777783 cites W1977314903 @default.
• W2097777783 cites W1977743352 @default.
• W2097777783 cites W1977776486 @default.
• W2097777783 cites W1977859379 @default.
• W2097777783 cites W1977860801 @default.
• W2097777783 cites W1977990240 @default.
• W2097777783 cites W1978118667 @default.
• W2097777783 cites W1978659393 @default.
• W2097777783 cites W1978668781 @default.
• W2097777783 cites W1978680540 @default.
• W2097777783 cites W1978695715 @default.
• W2097777783 cites W1979007603 @default.
• W2097777783 cites W1979139776 @default.
• W2097777783 cites W1979446903 @default.
• W2097777783 cites W1979460584 @default.
• W2097777783 cites W1979527613 @default.
• W2097777783 cites W1979645469 @default.
• W2097777783 cites W1979659124 @default.
• W2097777783 cites W1979786105 @default.
• W2097777783 cites W1980449640 @default.
• W2097777783 cites W1981162150 @default.
• W2097777783 cites W1981172305 @default.
• W2097777783 cites W1981515077 @default.
• W2097777783 cites W1981727895 @default.
• W2097777783 cites W1982173583 @default.
• W2097777783 cites W1982224042 @default.
• W2097777783 cites W1983066584 @default.
• W2097777783 cites W1983315832 @default.
• W2097777783 cites W1984204107 @default.
• W2097777783 cites W1984825989 @default.
• W2097777783 cites W1984898895 @default.
• W2097777783 cites W1985119207 @default.
• W2097777783 cites W1985363003 @default.
• W2097777783 cites W1986188355 @default.
• W2097777783 cites W1986383547 @default.

• next