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• W2097795983 abstract "No AccessJournal of UrologyInvestigative Urology1 Feb 1999THE EFFECTS OF CASTRATION ON RELAXATION OF RAT CORPUS CAVERNOSUM SMOOTH MUSCLE IN VITRO JOHN F. ALCORN, JAMES R. TOEPFER, and ROBERT E. LEIPHEIMER JOHN F. ALCORNJOHN F. ALCORN More articles by this author , JAMES R. TOEPFERJAMES R. TOEPFER More articles by this author , and ROBERT E. LEIPHEIMERROBERT E. LEIPHEIMER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61995-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: This study was conducted to investigate the role of testosterone (T) in regulating the relaxation of isolated rat corpus cavernosum strips in vitro. Materials and Methods: Male rats were divided into treatment groups of intact, castrate, and castrate with T replacement. Norepinephrine (NE) was added to contract each of the tissue strips. Next, sodium nitroprusside (SNP), experiment I, or 8-Br-cGMP, experiment II, was added to relax the cavernosum tissue. Percent relaxations were recorded for each treatment group at each dose level. Results: SNP was added to the NE-contracted tissues in doses of 10−4 and 10−3 M. In this experiment, castration significantly reduced tissue responsiveness to SNP and T replacement restored the response to intact levels. In the second experiment 8-Br-cGMP was added to the NE-contracted tissues in doses of 10−5 and 10−4 M. 8-Br-cGMP 10−4 M was significantly less effective in relaxing tissue from castrate animals as compared with intact controls. Again, T treatment restored the response to intact levels. Conclusions: Our results show a clear role of T in regulating the ability of corpus cavernosum tissue to relax when treated with SNP or 8-Br-cGMP in vitro. In addition, the data suggests that T regulates sites distal to the formation of cGMP in the relaxation pathway. 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Google Scholar 28 : Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis. J. Steroid Biochem.1980; 13: 1489. Google Scholar From the Department of Biological Sciences, Youngstown State University, Youngstown, Ohio(LEIPHEIMER) Requests for reprints: Department of Biological Sciences, Youngstown State University, Youngstown, OH, 44555.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByPINHEIRO A, COSTA W, CARDOSO L and SAMPAIO F (2018) ORGANIZATION AND RELATIVE CONTENT OF SMOOTH MUSCLE CELLS, COLLAGEN AND ELASTIC FIBERS IN THE CORPUS CAVERNOSUM OF RAT PENISJournal of Urology, VOL. 164, NO. 5, (1802-1806), Online publication date: 1-Nov-2000. Volume 161Issue 2February 1999Page: 686-689 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information JOHN F. ALCORN More articles by this author JAMES R. TOEPFER More articles by this author ROBERT E. LEIPHEIMER More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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