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- W2097803645 abstract "A previously uncharacterized 22-kDa Ca 2+ -binding protein that also binds guanosine nucleotides was characterized, cloned, and analyzed by electrophysiological techniques. The cloned protein, calexcitin, contains two EF-hands and also has homology with GTP-binding proteins in the ADP ribosylation factor family. In addition to binding two molecules of Ca 2+ , calexcitin bound GTP and possessed GTPase activity. Calexcitin is also a high affinity substrate for protein kinase C. Application of calexcitin to the inner surface of inside-out patches of human fibroblast membranes, in the presence of Ca 2+ and the absence of endogenous Ca 2+ /calmodulin kinase type II or protein kinase C activity, reduced the mean open time and mean open probability of 115 ± 6 pS K + channels. Calexcitin thus appears to directly regulate K + channels. When microinjected into molluscan neurons or rabbit cerebellar Purkinje cell dendrites, calexcitin was highly effective in enhancing membrane excitability. Because calexcitin translocates to the cell membrane after phosphorylation, calexcitin could serve as a Ca 2+ -activated signaling molecule that increases cellular excitability, which would in turn increase Ca 2+ influx through the membrane. This is also the first known instance of a GTP-binding protein that binds Ca 2+ ." @default.
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- W2097803645 date "1996-11-26" @default.
- W2097803645 modified "2023-09-23" @default.
- W2097803645 title "Calexcitin: A signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability" @default.
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- W2097803645 doi "https://doi.org/10.1073/pnas.93.24.13808" @default.
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