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- W2097804774 abstract "Significance The peripheral effect of ghrelin on energy metabolism has been controversial. Our study demonstrates a direct peripheral effect of ghrelin to increase de novo lipogenesis in hepatocytes. Moreover, we define mammalian target of rapamycin (mTOR)-peroxisome proliferator-activated receptor-γ (PPARγ) signaling pathway as the intracellular target of ghrelin in hepatocytes. The effect of ghrelin is mediated by the direct interaction between raptor and PPARγ. Our study identifies a previously unidentified pathway to treat NFALD via targeting hepatic ghrelin receptor/mTOR/PPARγ." @default.
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- W2097804774 date "2014-08-25" @default.
- W2097804774 modified "2023-10-15" @default.
- W2097804774 title "Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway" @default.
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- W2097804774 doi "https://doi.org/10.1073/pnas.1411571111" @default.
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