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• W2097806478 abstract "During development, mitral cells, the major output neurons of the olfactory bulb, project their axons caudolaterally into the telencephalon and form the lateral olfactory tract (LOT). Two types of guidance cues have been suggested for this projection. First, a long-range factor Slit, which is secreted from the septum, repels mitral cell axons into a caudolateral direction. Second, the pathway of mitral cell axons contains a subset of neurons designated as lot cells, which guide the axons through short-range interactions. It is not clear how these two guidance cues relate to each other and how they share the physiological roles. Here we examined the behavior of mitral cell axons in organotypic culture on ectopic application of Slit and inhibition of endogenous Slit signaling. The results suggested that the short-range guidance cue in the LOT pathway functions independently from Slit. Furthermore, our results showed that removal of the septum and inhibition of Slit signaling did not affect the projection of mitral cell axons. Although the septum and exogenous Slit can repel olfactory bulb axons, our results cast doubts on the physiological relevance of the septum and endogenous Slit in guiding the projection of mitral cell axons." @default.
• W2097806478 created "2016-06-24" @default.
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• W2097806478 date "2005-04-01" @default.
• W2097806478 modified "2023-09-30" @default.
• W2097806478 title "Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring" @default.
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• W2097806478 doi "https://doi.org/10.1136/gut.2004.055418" @default.
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