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• W2097808534 startingPage "4189" @default.
• W2097808534 abstract "Abstract During their asexual reproduction cycle (about 48 hours) in human red cells, Plasmodium falciparum parasites consume most of the host cell hemoglobin, far more than they require for protein biosynthesis. They also induce a large increase in the permeability of the host cell plasma membrane to allow for an increased traffic of nutrients and waste products. Why do the parasites digest hemoglobin in such excess? And how can infected red cells retain their integrity for the duration of the asexual cycle when comparably permeabilized uninfected cells hemolyse earlier? To address these questions we encoded the multiplicity of factors known to influence host cell volume in a mathematical model of the homeostasis of a parasitized red cell. The predicted volume changes were subjected to thorough experimental tests by monitoring the stage-related changes in the osmotic fragility of infected red cell populations. The results supported the model predictions of biphasic volume changes comprising transient shrinkage of infected cells with young trophozoites followed by continuous volume increase to about 10% lower than the critical hemolytic volume of approximately 150 fL by the end of the asexual cycle. Analysis of these results and of additional model predictions demonstrated that the osmotic stability of infected red cells can be preserved only by a large reduction in impermeant solute concentration within the host cell compartment. Thus, excess hemoglobin consumption represents an essential evolutionary strategy to prevent the premature hemolysis of the highly permeabilized infected red cell." @default.
• W2097808534 created "2016-06-24" @default.
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• W2097808534 creator A5041995002 @default.
• W2097808534 creator A5049033882 @default.
• W2097808534 date "2003-05-15" @default.
• W2097808534 modified "2023-10-04" @default.
• W2097808534 title "Excess hemoglobin digestion and the osmotic stability ofPlasmodium falciparum–infected red blood cells" @default.
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• W2097808534 doi "https://doi.org/10.1182/blood-2002-08-2654" @default.
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• W2097808534 hasPublicationYear "2003" @default.
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