FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097831215> ?p ?o ?g. }

• W2097831215 abstract "The expression of proinflammatory protein tissue transglutaminase 2 (TG2) is frequently upregulated in multiple cancer cell types. However, the exact role of TG2 in cancer cells is not well-understood. We recently initiated studies to determine the significance of TG2 in cancer cells and observed that sustained expression of TG2 resulted in epithelial-to-mesenchymal transition (EMT) and promoted cancer stem cell (CSC) traits in mammary epithelial cells. These results suggested that TG2 could serve as a promising therapeutic target for overcoming chemoresistance and inhibiting metastatic spread of cancer cells.Using various mutant constructs, we analyzed the activity of TG2 that is essential for promoting the EMT-CSC phenotype.Our results suggest that catalytically inactive TG2 (TG2-C277S) is as effective as wild-type TG2 (TG2-WT) in inducing the EMT-CSC in mammary epithelial cells. In contrast, overexpression of a GTP-binding-deficient mutant (TG2-R580A) was completely incompetent in this regard. Moreover, TG2-dependent activation of the proinflammatory transcription factor NF-κB is deemed essential for promoting the EMT-CSC phenotype in mammary epithelial cells.Our results suggest that the transamidation activity of TG2 is not essential for promoting its oncogenic functions and provide a strong rationale for developing small-molecule inhibitors to block GTP-binding pockets of TG2. Such inhibitors may have great potential for inhibiting the TG2-regulated pathways, reversing drug resistance and inhibiting the metastasis of cancer cells." @default.
• W2097831215 created "2016-06-24" @default.
• W2097831215 creator A5001569945 @default.
• W2097831215 creator A5015911393 @default.
• W2097831215 creator A5037193058 @default.
• W2097831215 creator A5048675624 @default.
• W2097831215 creator A5069988397 @default.
• W2097831215 creator A5077873968 @default.
• W2097831215 creator A5088712768 @default.
• W2097831215 date "2012-01-06" @default.
• W2097831215 modified "2023-10-16" @default.
• W2097831215 title "Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells" @default.
• W2097831215 cites W1577973593 @default.
• W2097831215 cites W1964081206 @default.
• W2097831215 cites W1967455040 @default.
• W2097831215 cites W1972607473 @default.
• W2097831215 cites W1974823430 @default.
• W2097831215 cites W1976066035 @default.
• W2097831215 cites W1987899161 @default.
• W2097831215 cites W1992101294 @default.
• W2097831215 cites W1995228256 @default.
• W2097831215 cites W1996834104 @default.
• W2097831215 cites W2000185144 @default.
• W2097831215 cites W2004419844 @default.
• W2097831215 cites W2005876884 @default.
• W2097831215 cites W2005926906 @default.
• W2097831215 cites W2007456673 @default.
• W2097831215 cites W2014683547 @default.
• W2097831215 cites W2014691022 @default.
• W2097831215 cites W2015779044 @default.
• W2097831215 cites W2017729871 @default.
• W2097831215 cites W2022968099 @default.
• W2097831215 cites W2028593825 @default.
• W2097831215 cites W2029657029 @default.
• W2097831215 cites W2038390742 @default.
• W2097831215 cites W2040068921 @default.
• W2097831215 cites W2074668730 @default.
• W2097831215 cites W2076583198 @default.
• W2097831215 cites W2085907010 @default.
• W2097831215 cites W2100545793 @default.
• W2097831215 cites W2115847623 @default.
• W2097831215 cites W2115978612 @default.
• W2097831215 cites W2126351542 @default.
• W2097831215 cites W2153899562 @default.
• W2097831215 cites W2154589460 @default.
• W2097831215 cites W2166782237 @default.
• W2097831215 cites W2168388492 @default.
• W2097831215 cites W2762697978 @default.
• W2097831215 cites W4232487434 @default.
• W2097831215 doi "https://doi.org/10.1186/bcr3085" @default.
• W2097831215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3496119" @default.
• W2097831215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22225906" @default.
• W2097831215 hasPublicationYear "2012" @default.
• W2097831215 type Work @default.
• W2097831215 sameAs 2097831215 @default.
• W2097831215 citedByCount "52" @default.
• W2097831215 countsByYear W20978312152012 @default.
• W2097831215 countsByYear W20978312152013 @default.
• W2097831215 countsByYear W20978312152014 @default.
• W2097831215 countsByYear W20978312152015 @default.
• W2097831215 countsByYear W20978312152016 @default.
• W2097831215 countsByYear W20978312152017 @default.
• W2097831215 countsByYear W20978312152018 @default.
• W2097831215 countsByYear W20978312152019 @default.
• W2097831215 countsByYear W20978312152020 @default.
• W2097831215 countsByYear W20978312152021 @default.
• W2097831215 countsByYear W20978312152022 @default.
• W2097831215 countsByYear W20978312152023 @default.
• W2097831215 crossrefType "journal-article" @default.
• W2097831215 hasAuthorship W2097831215A5001569945 @default.
• W2097831215 hasAuthorship W2097831215A5015911393 @default.
• W2097831215 hasAuthorship W2097831215A5037193058 @default.
• W2097831215 hasAuthorship W2097831215A5048675624 @default.
• W2097831215 hasAuthorship W2097831215A5069988397 @default.
• W2097831215 hasAuthorship W2097831215A5077873968 @default.
• W2097831215 hasAuthorship W2097831215A5088712768 @default.
• W2097831215 hasBestOaLocation W20978312151 @default.
• W2097831215 hasConcept C121608353 @default.
• W2097831215 hasConcept C164027704 @default.
• W2097831215 hasConcept C178498320 @default.
• W2097831215 hasConcept C181199279 @default.
• W2097831215 hasConcept C203014093 @default.
• W2097831215 hasConcept C2776914184 @default.
• W2097831215 hasConcept C2779013556 @default.
• W2097831215 hasConcept C28328180 @default.
• W2097831215 hasConcept C502942594 @default.
• W2097831215 hasConcept C54355233 @default.
• W2097831215 hasConcept C55427017 @default.
• W2097831215 hasConcept C55493867 @default.
• W2097831215 hasConcept C76419328 @default.
• W2097831215 hasConcept C86803240 @default.
• W2097831215 hasConcept C95444343 @default.
• W2097831215 hasConcept C96232424 @default.
• W2097831215 hasConceptScore W2097831215C121608353 @default.
• W2097831215 hasConceptScore W2097831215C164027704 @default.
• W2097831215 hasConceptScore W2097831215C178498320 @default.
• W2097831215 hasConceptScore W2097831215C181199279 @default.
• W2097831215 hasConceptScore W2097831215C203014093 @default.
• W2097831215 hasConceptScore W2097831215C2776914184 @default.
• W2097831215 hasConceptScore W2097831215C2779013556 @default.

• next