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• W2097879423 abstract "<i >Objective</i>. This study aimed to investigate improvements in inflammatory mediator levels in induced sputum and airway hyperresponsiveness (AHR) in cough variant asthma (CVA) during long-term inhaled corticosteroid (ICS) treatment. <i >Patients and Methods</i>. Patients with CVA (<svg style=vertical-align:-0.17555pt;width:48.4375px; id=M1 height=11.1 version=1.1 viewBox=0 0 48.4375 11.1 width=48.4375 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.1)> <g transform=translate(72,-63.12)> <text transform=matrix(1,0,0,-1,-71.95,63.35)> <tspan style=font-size: 12.50px; x=0 y=0>𝑁</tspan> <tspan style=font-size: 12.50px; x=14.103384 y=0>=</tspan> <tspan style=font-size: 12.50px; x=26.143772 y=0>3</tspan> <tspan style=font-size: 12.50px; x=32.395271 y=0>5</tspan> </text> </g> </g> </svg>) and classic asthma (<svg style=vertical-align:-0.17555pt;width:48.4375px; id=M2 height=11.0375 version=1.1 viewBox=0 0 48.4375 11.0375 width=48.4375 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.0375)> <g transform=translate(72,-63.17)> <text transform=matrix(1,0,0,-1,-71.95,63.4)> <tspan style=font-size: 12.50px; x=0 y=0>𝑁</tspan> <tspan style=font-size: 12.50px; x=14.103384 y=0>=</tspan> <tspan style=font-size: 12.50px; x=26.143772 y=0>2</tspan> <tspan style=font-size: 12.50px; x=32.395271 y=0>6</tspan> </text> </g> </g> </svg>) and healthy subjects (<svg style=vertical-align:-0.0pt;width:48.4375px; id=M3 height=10.6875 version=1.1 viewBox=0 0 48.4375 10.6875 width=48.4375 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.6875)> <g transform=translate(72,-63.45)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑁</tspan> <tspan style=font-size: 12.50px; x=14.103384 y=0>=</tspan> <tspan style=font-size: 12.50px; x=26.143772 y=0>2</tspan> <tspan style=font-size: 12.50px; x=32.395271 y=0>4</tspan> </text> </g> </g> </svg>) were recruited into this study. All patients were treated with budesonide (400&#x2009;<i >&#x3bc;</i>g/day). Measurement of inflammatory mediators in induced sputum and PD20-FEV<sub >1</sub> (the accumulated provocative dose resulting in a 20&#x25; decrease in FEV<sub >1</sub>) in histamine-challenged subjects was performed every three months after the start of medication. Interleukin- (IL-) 5 and IL-10 were assayed by ELISA, and the percentage of eosinophils was detected with Giemsa stain. Trends during the follow-up period were analyzed using a general linear model. <i >Results</i>. Inflammatory mediator levels in induced sputum and PD20-FEV<sub >1</sub> in patients with CVA and classic asthma differed from those in the control group, although no differences were found in the two asthmatic groups. PD20-FEV<sub >1</sub> significantly increased in CVA patients after ICS treatment for 3 months, while classic asthma patients exhibited a delayed change in AHR. After ICS treatment, levels of IL-5 and IL-10 as well as the percentage of eosinophils in the CVA group were altered at 3 months and 6 months, respectively. Accordingly, the level of inflammatory mediators in classic asthma changed more slowly. <i >Conclusion</i>. CVA has a greater improvement in airway inflammation and airway hyperresponsiveness (AHR) than classic asthma with respect to inhaled corticosteroid (ICS). Short-term ICS considerably reduces AHR although longer treatment is required for complete control of airway inflammation." @default.
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• W2097879423 date "2012-01-01" @default.
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• W2097879423 title "Inflammatory Mediators in Induced Sputum and Airway Hyperresponsiveness in Cough Variant Asthma during Long-Term Inhaled Corticosteroid Treatment" @default.
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• W2097879423 doi "https://doi.org/10.1155/2012/403868" @default.
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