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• W2097888265 startingPage "C715" @default.
• W2097888265 abstract "The killifish, Fundulus heteroclitus, is a euryhaline teleost fish capable of adapting rapidly to transfer from freshwater (FW) to four times seawater (SW). To investigate osmoregulation at a molecular level, a 5.7-kilobase cDNA homologous to human cystic fibrosis transmembrane conductance regulator (hCFTR) was isolated from a gill cDNA library from SW-adapted killifish. This cDNA encodes a protein product (kfCFTR) that is 59% identical to hCFTR, the most divergent form of CFTR characterized to date. Expression of kfCFTR in Xenopus oocytes generated adenosine 3',5'-cyclic monophosphate-activated, Cl(-)-selective currents similar to those generated by hCFTR. In SW-adapted killifish, kfCFTR was expressed at high levels in the gill, opercular epithelium, and intestine. After abrupt exposure of FW-adapted killifish to SW, kfCFTR expression in the gill increased severalfold, suggesting a role for kfCFTR in salinity adaptation. Under similar conditions, plasma Na+ levels rose significantly after 8 h and then fell, although it is not known whether these changes are directly responsible for the changes in kfCFTR expression. The killifish provides a unique opportunity to understand teleost osmoregulation and the role of CFTR." @default.
• W2097888265 created "2016-06-24" @default.
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• W2097888265 date "1998-03-01" @default.
• W2097888265 modified "2023-09-24" @default.
• W2097888265 title "A divergent CFTR homologue: highly regulated salt transport in the euryhaline teleost<i>F. heteroclitus</i>" @default.
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• W2097888265 doi "https://doi.org/10.1152/ajpcell.1998.274.3.c715" @default.
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