FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097891358> ?p ?o ?g. }

• W2097891358 endingPage "2699S" @default.
• W2097891358 startingPage "2697S" @default.
• W2097891358 abstract "Pregnancy, mammary epithelial differentiation, and breast cancer risk Our understanding of the proposed protective role of mammary epithelial differentiation against breast cancer is based mainly on the important work by Irma and Jose Russo (1–3). The Russos have shown that terminal end buds (TEBs) in a rat mammary gland are the structures that give rise to malignant mammary tumors on exposure to chemical carcinogens, particularly to 7,12-dimethylbenz[a]anthracene, a polycyclic aromatic hydrocarbon. Breast cancers in women originate from a corresponding structure called the terminal ductal lobular unit (TDLU) or Lobule type 1 (Lob 1) (4). TEBs play a central role in mammary gland development in rats. The mammary fat pad is initially formed during the fetal period, and it contains limited stroma and a rudimentary epithelial tree. The epithelium is quiescent until about 3 weeks of postnatal age, when large club-shaped TEBs appear. They are the most actively growing terminal ductal structures and are believed to contain a pluripotent stem cell population that potentially gives rise to breast cancer (3,5,6). TEBs lead the growth of the epithelial ducts through the fat pad and eventually regress to terminal ducts or differentiate to alveolar buds and further to lobules when the mammary fat pad is filled with a highly branched ductal tree. These alveolar structures do not give rise to malignant tumors. The work by the Russos and others (7,8) has shown that a key developmental event, pregnancy, as well as exposures that mimic the hormonal environment of pregnancy induce differentiation of the TEB/ TDLU and dramatically reduce the risk of breast cancer. The idea that differentiation explains the protective effects of pregnancy has been questioned by several investigators (9). Arguing against this idea are findings that induction of differentiation by placental lactogen or the dopamine receptor inhibitor perphenazine (PPZ) does not reduce breast cancer risk in animal models. An alternative hypothesis has been proposed by Siverman et al. (10); according to his ‘‘cell fate hypothesis,’’ pregnancy hormones induce a molecular switch in mammary stem cells that leads to changes in cell proliferation and response to DNA damage. The molecular changes then inhibit cell proliferation in response to subsequent exposure to hormones or carcinogens (10,11)." @default.
• W2097891358 created "2016-06-24" @default.
• W2097891358 creator A5001200228 @default.
• W2097891358 creator A5007404705 @default.
• W2097891358 creator A5020391084 @default.
• W2097891358 creator A5027357317 @default.
• W2097891358 date "2006-10-01" @default.
• W2097891358 modified "2023-10-11" @default.
• W2097891358 title "Differentiation of Mammary Gland as a Mechanism to Reduce Breast Cancer Risk" @default.
• W2097891358 cites W1893896651 @default.
• W2097891358 cites W1930987507 @default.
• W2097891358 cites W1966251618 @default.
• W2097891358 cites W1973968998 @default.
• W2097891358 cites W1980775229 @default.
• W2097891358 cites W1995584874 @default.
• W2097891358 cites W2003118503 @default.
• W2097891358 cites W2003315759 @default.
• W2097891358 cites W2018733061 @default.
• W2097891358 cites W2030698703 @default.
• W2097891358 cites W2032297232 @default.
• W2097891358 cites W2040353259 @default.
• W2097891358 cites W2051490507 @default.
• W2097891358 cites W2051592955 @default.
• W2097891358 cites W2052351468 @default.
• W2097891358 cites W2052929447 @default.
• W2097891358 cites W2057795638 @default.
• W2097891358 cites W2073701343 @default.
• W2097891358 cites W2081069998 @default.
• W2097891358 cites W2123139458 @default.
• W2097891358 cites W2125770442 @default.
• W2097891358 cites W2136982991 @default.
• W2097891358 cites W2142105477 @default.
• W2097891358 cites W2146324932 @default.
• W2097891358 cites W2158029937 @default.
• W2097891358 cites W2168483218 @default.
• W2097891358 cites W2168746754 @default.
• W2097891358 doi "https://doi.org/10.1093/jn/136.10.2697s" @default.
• W2097891358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16988155" @default.
• W2097891358 hasPublicationYear "2006" @default.
• W2097891358 type Work @default.
• W2097891358 sameAs 2097891358 @default.
• W2097891358 citedByCount "19" @default.
• W2097891358 countsByYear W20978913582012 @default.
• W2097891358 countsByYear W20978913582013 @default.
• W2097891358 countsByYear W20978913582018 @default.
• W2097891358 countsByYear W20978913582019 @default.
• W2097891358 countsByYear W20978913582020 @default.
• W2097891358 countsByYear W20978913582021 @default.
• W2097891358 countsByYear W20978913582022 @default.
• W2097891358 crossrefType "journal-article" @default.
• W2097891358 hasAuthorship W2097891358A5001200228 @default.
• W2097891358 hasAuthorship W2097891358A5007404705 @default.
• W2097891358 hasAuthorship W2097891358A5020391084 @default.
• W2097891358 hasAuthorship W2097891358A5027357317 @default.
• W2097891358 hasBestOaLocation W20978913581 @default.
• W2097891358 hasConcept C111472728 @default.
• W2097891358 hasConcept C121608353 @default.
• W2097891358 hasConcept C126322002 @default.
• W2097891358 hasConcept C134018914 @default.
• W2097891358 hasConcept C138885662 @default.
• W2097891358 hasConcept C143998085 @default.
• W2097891358 hasConcept C2778001805 @default.
• W2097891358 hasConcept C42407357 @default.
• W2097891358 hasConcept C530470458 @default.
• W2097891358 hasConcept C71924100 @default.
• W2097891358 hasConcept C86803240 @default.
• W2097891358 hasConcept C89611455 @default.
• W2097891358 hasConceptScore W2097891358C111472728 @default.
• W2097891358 hasConceptScore W2097891358C121608353 @default.
• W2097891358 hasConceptScore W2097891358C126322002 @default.
• W2097891358 hasConceptScore W2097891358C134018914 @default.
• W2097891358 hasConceptScore W2097891358C138885662 @default.
• W2097891358 hasConceptScore W2097891358C143998085 @default.
• W2097891358 hasConceptScore W2097891358C2778001805 @default.
• W2097891358 hasConceptScore W2097891358C42407357 @default.
• W2097891358 hasConceptScore W2097891358C530470458 @default.
• W2097891358 hasConceptScore W2097891358C71924100 @default.
• W2097891358 hasConceptScore W2097891358C86803240 @default.
• W2097891358 hasConceptScore W2097891358C89611455 @default.
• W2097891358 hasIssue "10" @default.
• W2097891358 hasLocation W20978913581 @default.
• W2097891358 hasLocation W20978913582 @default.
• W2097891358 hasOpenAccess W2097891358 @default.
• W2097891358 hasPrimaryLocation W20978913581 @default.
• W2097891358 hasRelatedWork W1966504330 @default.
• W2097891358 hasRelatedWork W1979139803 @default.
• W2097891358 hasRelatedWork W2002315461 @default.
• W2097891358 hasRelatedWork W2016202130 @default.
• W2097891358 hasRelatedWork W2026301838 @default.
• W2097891358 hasRelatedWork W2155981800 @default.
• W2097891358 hasRelatedWork W2224319365 @default.
• W2097891358 hasRelatedWork W2748952813 @default.
• W2097891358 hasRelatedWork W4248212310 @default.
• W2097891358 hasRelatedWork W4252963116 @default.
• W2097891358 hasVolume "136" @default.
• W2097891358 isParatext "false" @default.
• W2097891358 isRetracted "false" @default.
• W2097891358 magId "2097891358" @default.

• next