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- W2097904070 abstract "Interleukin-10 (IL-10) activates a diverse array of functional responses in mononuclear phagocytes. Functional IL-10 receptor (IL-10R) complexes are tetramers consisting of two IL-10R1 polypeptide chains and two IL-10R2 chains. Binding of IL-10 to the extracellular domain of IL-10R1 activates phosphorylation of the receptor-associated Janus tyrosine kinases, JAK1 and Tyk2. These kinases then phosphorylate specific tyrosine residues (Y446 and Y496) on the intracellular domain of the IL-10R1 chain. Once phosphorylated, these tyrosine residues (and their flanking peptide sequences) serve as temporary docking sites for the latent transcription factor, STAT3 (signal transducer and activator of transcription-3). STAT3 binds to these sites via its SH2 (Src homology 2) domain, and is, in turn, tyrosine-phosphorylated by the receptor-associated JAKs. It then homodimerizes and translocates to the nucleus where it binds with high affinity to STAT-binding elements (SBE) in the promoters of various IL-10-responsive genes. One of these genes, SOCS-3 (Suppressor of Cytokine Signaling-3) is a member of a newly identified family of genes that inhibit JAK/STAT-dependent signaling. Moreover, the ability of IL-10 to induce de novo synthesis of SOCS-3 in monocytes correlates with its ability to inhibit expression of many genes in these cells, including endotoxin-inducible cytokines such as tumor necrosis factor-alpha (TNF-alpha) and IL-1. Thus, the ability of IL-10 to inhibit gene expression in monocytes is associated with its ability to rapidly induce synthesis of SOCS-3." @default.
- W2097904070 created "2016-06-24" @default.
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- W2097904070 date "1999-06-01" @default.
- W2097904070 modified "2023-10-14" @default.
- W2097904070 title "The Interleukin-10 Signal Transduction Pathway and Regulation of Gene Expression in Mononuclear Phagocytes" @default.
- W2097904070 cites W1487331723 @default.
- W2097904070 cites W1488478985 @default.
- W2097904070 cites W1499527462 @default.
- W2097904070 cites W1502244845 @default.
- W2097904070 cites W1510351145 @default.
- W2097904070 cites W1515615230 @default.
- W2097904070 cites W1517658874 @default.
- W2097904070 cites W1532157284 @default.
- W2097904070 cites W1538802759 @default.
- W2097904070 cites W1549980625 @default.
- W2097904070 cites W1573470869 @default.
- W2097904070 cites W1587500817 @default.
- W2097904070 cites W1634459475 @default.
- W2097904070 cites W1668039320 @default.
- W2097904070 cites W1670792975 @default.
- W2097904070 cites W1713837849 @default.
- W2097904070 cites W1778529618 @default.
- W2097904070 cites W1782561717 @default.
- W2097904070 cites W1957298029 @default.
- W2097904070 cites W1969337504 @default.
- W2097904070 cites W1970461847 @default.
- W2097904070 cites W1973155132 @default.
- W2097904070 cites W1973654655 @default.
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- W2097904070 cites W1981469317 @default.
- W2097904070 cites W1997681100 @default.
- W2097904070 cites W2002144356 @default.
- W2097904070 cites W2015153748 @default.
- W2097904070 cites W2022819740 @default.
- W2097904070 cites W2023845407 @default.
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- W2097904070 cites W2030624761 @default.
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- W2097904070 cites W2031156245 @default.
- W2097904070 cites W2033297307 @default.
- W2097904070 cites W2036072927 @default.
- W2097904070 cites W2036500213 @default.
- W2097904070 cites W2038613403 @default.
- W2097904070 cites W2038977750 @default.
- W2097904070 cites W2038992843 @default.
- W2097904070 cites W2047999732 @default.
- W2097904070 cites W2052172628 @default.
- W2097904070 cites W2055336483 @default.
- W2097904070 cites W2060546545 @default.
- W2097904070 cites W2067626539 @default.
- W2097904070 cites W2069035291 @default.
- W2097904070 cites W2073956665 @default.
- W2097904070 cites W2078730804 @default.
- W2097904070 cites W2083466222 @default.
- W2097904070 cites W2084990572 @default.
- W2097904070 cites W2093822115 @default.
- W2097904070 cites W2098277628 @default.
- W2097904070 cites W2098788888 @default.
- W2097904070 cites W2101771134 @default.
- W2097904070 cites W2105960411 @default.
- W2097904070 cites W2108786544 @default.
- W2097904070 cites W2113936644 @default.
- W2097904070 cites W2114639316 @default.
- W2097904070 cites W2119596771 @default.
- W2097904070 cites W2122506044 @default.
- W2097904070 cites W2123795063 @default.
- W2097904070 cites W2146271551 @default.
- W2097904070 cites W2147516175 @default.
- W2097904070 cites W2153398168 @default.
- W2097904070 cites W2154057864 @default.
- W2097904070 cites W2158154746 @default.
- W2097904070 cites W2170256455 @default.
- W2097904070 cites W2191654227 @default.
- W2097904070 cites W2414412010 @default.
- W2097904070 cites W2472390202 @default.
- W2097904070 cites W4230023618 @default.
- W2097904070 cites W4231581694 @default.
- W2097904070 cites W4241940863 @default.
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- W2097904070 doi "https://doi.org/10.1089/107999099313695" @default.
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