FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097906234> ?p ?o ?g. }

• W2097906234 endingPage "479" @default.
• W2097906234 startingPage "471" @default.
• W2097906234 abstract "The present study focused on the cellular remodeling of steroidogenic tissue in the domestic turkey (Meleagris gallopavo) adrenal gland in response to dietary protein restriction stress. Immature male turkeys (1 week old) were fed isocaloric synthetic diets containing either 28% (control) or 8% (restriction) soy protein for 4 weeks. Adrenal glands were processed for the isolation of density- separable, visibly distinct adrenal steroidogenic cell subpopulations: three low-density subpopulations [LDAC-1 (rho = 1. 0350-1.0490 g/ml), LDAC-2 (rho = 1.0490-1.0570 g/ml), and LDAC-3 (rho = 1.0570-1.0585 g/ml)] and one high-density subpopulation [HDAC (rho = 1.0590-1.0720 g/ml)]. Dietary protein restriction increased the proportion of LDAC-3 and HDAC by 98 and 350%, respectively, and decreased LDAC-2 by 46%. LDAC-1 also showed signs of proportional decrement. To determine the role of cell death in this process, the potential for apoptosis was assessed in adrenal tissue and isolated adrenal steroidogenic cells using short-term culture followed by analysis of oligonucleosome formation. Basal, culture-triggered oligonucleosome formation of tissue and cells derived from protein-restricted birds was 80% greater than that of tissue and cells derived from control birds. This differential in apoptotic potential persisted with a variety of treatments, in vitro. Apoptotic potential was suppressed by human adrenocorticotropin and enhanced by angiotensin II (Ang II). The proapoptotic effect of Ang II (100 nM) with adrenal fragments was inhibited by the Ang II receptor antagonist [Sar(1), Ile(8)]ang II (10 microM) to below basal values (by about 60%), but the inhibition was surmountable by high concentrations (10 and 100 microM) of Ang II. The antagonist also attenuated basal, culture-triggered DNA fragmentation of tissue and cells, suggesting that at least part of the basal DNA fragmentation was due to intrinsically generated Ang II. Differences in apoptotic potential were also apparent with cell subpopulations. Compared to control subpopulations, protein restriction enhanced basal oligonucleosome formation in LDAC-1 and -2 by 38 and 122%, respectively, and reduced it in LDAC-3 and HDAC by 53 and 70%, respectively. These data suggest a role for apoptotic cell death in the remodeling of turkey adrenal steroidogenic tissue induced by dietary protein restriction. In addition, other data suggest that Ang II is an important regulator of adrenal steroidogenic cell turnover in the avian adrenal gland." @default.
• W2097906234 created "2016-06-24" @default.
• W2097906234 creator A5033594895 @default.
• W2097906234 creator A5052744147 @default.
• W2097906234 date "2000-06-01" @default.
• W2097906234 modified "2023-09-26" @default.
• W2097906234 title "Remodeling of Turkey Adrenal Steroidogenic Tissue Induced by Dietary Protein Restriction: The Potential Role of Cell Death" @default.
• W2097906234 cites W1969127031 @default.
• W2097906234 cites W1983201976 @default.
• W2097906234 cites W2018370633 @default.
• W2097906234 cites W2045178701 @default.
• W2097906234 cites W2049661605 @default.
• W2097906234 cites W2065077085 @default.
• W2097906234 cites W2078224369 @default.
• W2097906234 cites W2084158084 @default.
• W2097906234 cites W2085188280 @default.
• W2097906234 cites W2118696823 @default.
• W2097906234 doi "https://doi.org/10.1006/gcen.2000.7486" @default.
• W2097906234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10843798" @default.
• W2097906234 hasPublicationYear "2000" @default.
• W2097906234 type Work @default.
• W2097906234 sameAs 2097906234 @default.
• W2097906234 citedByCount "11" @default.
• W2097906234 countsByYear W20979062342012 @default.
• W2097906234 countsByYear W20979062342015 @default.
• W2097906234 countsByYear W20979062342017 @default.
• W2097906234 countsByYear W20979062342018 @default.
• W2097906234 countsByYear W20979062342020 @default.
• W2097906234 countsByYear W20979062342021 @default.
• W2097906234 countsByYear W20979062342022 @default.
• W2097906234 countsByYear W20979062342023 @default.
• W2097906234 crossrefType "journal-article" @default.
• W2097906234 hasAuthorship W2097906234A5033594895 @default.
• W2097906234 hasAuthorship W2097906234A5052744147 @default.
• W2097906234 hasConcept C126322002 @default.
• W2097906234 hasConcept C134018914 @default.
• W2097906234 hasConcept C190283241 @default.
• W2097906234 hasConcept C2780694816 @default.
• W2097906234 hasConcept C31573885 @default.
• W2097906234 hasConcept C55493867 @default.
• W2097906234 hasConcept C71924100 @default.
• W2097906234 hasConcept C86803240 @default.
• W2097906234 hasConceptScore W2097906234C126322002 @default.
• W2097906234 hasConceptScore W2097906234C134018914 @default.
• W2097906234 hasConceptScore W2097906234C190283241 @default.
• W2097906234 hasConceptScore W2097906234C2780694816 @default.
• W2097906234 hasConceptScore W2097906234C31573885 @default.
• W2097906234 hasConceptScore W2097906234C55493867 @default.
• W2097906234 hasConceptScore W2097906234C71924100 @default.
• W2097906234 hasConceptScore W2097906234C86803240 @default.
• W2097906234 hasIssue "3" @default.
• W2097906234 hasLocation W20979062341 @default.
• W2097906234 hasLocation W20979062342 @default.
• W2097906234 hasOpenAccess W2097906234 @default.
• W2097906234 hasPrimaryLocation W20979062341 @default.
• W2097906234 hasRelatedWork W1979463295 @default.
• W2097906234 hasRelatedWork W1989923202 @default.
• W2097906234 hasRelatedWork W1994074398 @default.
• W2097906234 hasRelatedWork W2002982523 @default.
• W2097906234 hasRelatedWork W2117266708 @default.
• W2097906234 hasRelatedWork W2147779903 @default.
• W2097906234 hasRelatedWork W2160355439 @default.
• W2097906234 hasRelatedWork W2171647298 @default.
• W2097906234 hasRelatedWork W2976338489 @default.
• W2097906234 hasRelatedWork W4237263762 @default.
• W2097906234 hasVolume "118" @default.
• W2097906234 isParatext "false" @default.
• W2097906234 isRetracted "false" @default.
• W2097906234 magId "2097906234" @default.
• W2097906234 workType "article" @default.