FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097908085> ?p ?o ?g. }

• W2097908085 endingPage "306" @default.
• W2097908085 startingPage "299" @default.
• W2097908085 abstract "Gliomatosis cerebri (GC) represents an unfortunate, rare variant of glioma with a very poor prognosis. Given this lesion's rarity, little information exists on appropriate treatment options. The diffuse, infiltrative nature of GC precludes any surgical resection and limits therapy. Because of the improved survival seen with the use of temozolomide (TMZ) in malignant glioma, a rigorous systematic review of the published literature was performed to ascertain the benefit of TMZ in GC. We identified all GC cases in the literature where there was enough information to ascertain a clear response to a specific chemoradiotherapeutic treatment. In addition to our experience with a recent case, we have identified 61 patients with GC in the published literature who demonstrated a positive radiographic or clinic response after treatment. Statistical analysis of survival was performed by Kaplan-Meier analysis. A positive radiographic and clinical response was seen in patients ranging in age from 4 to 84 years. Overall median survival in patients diagnosed with GC who demonstrated a response after treatment was 25 months, with 1- and 2-year survival rates of 89% and 55%, respectively. The most common treatment regimens for responders included TMZ alone (26.2%), external whole-brain radiotherapy (WBRT) (26.2%), and concomitant TMZ and WBRT (20%). Our patient was treated with concomitant TMZ (150 mg/m2/day over 5 days) and WBRT (50 Gy) and has remained with a complete radiographic response after 36 months. In conclusion, patients with GC confirmed by surgical biopsy should be aggressively treated with concomitant TMZ and WBRT, as marked responses have been seen, and this appears to offer overall survival benefit." @default.
• W2097908085 created "2016-06-24" @default.
• W2097908085 creator A5009596244 @default.
• W2097908085 creator A5024310978 @default.
• W2097908085 creator A5084417480 @default.
• W2097908085 date "2012-05-01" @default.
• W2097908085 modified "2023-10-16" @default.
• W2097908085 title "Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy" @default.
• W2097908085 cites W1790847442 @default.
• W2097908085 cites W1973198497 @default.
• W2097908085 cites W1984225353 @default.
• W2097908085 cites W1985573533 @default.
• W2097908085 cites W2001890713 @default.
• W2097908085 cites W2004621001 @default.
• W2097908085 cites W2004758190 @default.
• W2097908085 cites W2005663451 @default.
• W2097908085 cites W2011827319 @default.
• W2097908085 cites W2013436803 @default.
• W2097908085 cites W2015608790 @default.
• W2097908085 cites W2017305699 @default.
• W2097908085 cites W2020611061 @default.
• W2097908085 cites W2023242225 @default.
• W2097908085 cites W2024157244 @default.
• W2097908085 cites W2024514018 @default.
• W2097908085 cites W2033128037 @default.
• W2097908085 cites W2044519685 @default.
• W2097908085 cites W2050334382 @default.
• W2097908085 cites W2054445062 @default.
• W2097908085 cites W2064214863 @default.
• W2097908085 cites W2065588026 @default.
• W2097908085 cites W2074700361 @default.
• W2097908085 cites W2080605970 @default.
• W2097908085 cites W2082398137 @default.
• W2097908085 cites W2086369140 @default.
• W2097908085 cites W2092033921 @default.
• W2097908085 cites W2092378102 @default.
• W2097908085 cites W2096287682 @default.
• W2097908085 cites W2105100844 @default.
• W2097908085 cites W2111506152 @default.
• W2097908085 cites W2115080129 @default.
• W2097908085 cites W2141699748 @default.
• W2097908085 cites W2159757407 @default.
• W2097908085 cites W2167713837 @default.
• W2097908085 cites W2169253833 @default.
• W2097908085 cites W2314151038 @default.
• W2097908085 doi "https://doi.org/10.1016/j.clineuro.2012.01.030" @default.
• W2097908085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22341931" @default.
• W2097908085 hasPublicationYear "2012" @default.
• W2097908085 type Work @default.
• W2097908085 sameAs 2097908085 @default.
• W2097908085 citedByCount "15" @default.
• W2097908085 countsByYear W20979080852013 @default.
• W2097908085 countsByYear W20979080852014 @default.
• W2097908085 countsByYear W20979080852015 @default.
• W2097908085 countsByYear W20979080852016 @default.
• W2097908085 countsByYear W20979080852018 @default.
• W2097908085 countsByYear W20979080852019 @default.
• W2097908085 countsByYear W20979080852021 @default.
• W2097908085 countsByYear W20979080852022 @default.
• W2097908085 crossrefType "journal-article" @default.
• W2097908085 hasAuthorship W2097908085A5009596244 @default.
• W2097908085 hasAuthorship W2097908085A5024310978 @default.
• W2097908085 hasAuthorship W2097908085A5084417480 @default.
• W2097908085 hasConcept C126322002 @default.
• W2097908085 hasConcept C126838900 @default.
• W2097908085 hasConcept C141071460 @default.
• W2097908085 hasConcept C142724271 @default.
• W2097908085 hasConcept C143998085 @default.
• W2097908085 hasConcept C2775934546 @default.
• W2097908085 hasConcept C2777389519 @default.
• W2097908085 hasConcept C2778227246 @default.
• W2097908085 hasConcept C2778256017 @default.
• W2097908085 hasConcept C2779130545 @default.
• W2097908085 hasConcept C2779384505 @default.
• W2097908085 hasConcept C2781156865 @default.
• W2097908085 hasConcept C502942594 @default.
• W2097908085 hasConcept C509974204 @default.
• W2097908085 hasConcept C71924100 @default.
• W2097908085 hasConceptScore W2097908085C126322002 @default.
• W2097908085 hasConceptScore W2097908085C126838900 @default.
• W2097908085 hasConceptScore W2097908085C141071460 @default.
• W2097908085 hasConceptScore W2097908085C142724271 @default.
• W2097908085 hasConceptScore W2097908085C143998085 @default.
• W2097908085 hasConceptScore W2097908085C2775934546 @default.
• W2097908085 hasConceptScore W2097908085C2777389519 @default.
• W2097908085 hasConceptScore W2097908085C2778227246 @default.
• W2097908085 hasConceptScore W2097908085C2778256017 @default.
• W2097908085 hasConceptScore W2097908085C2779130545 @default.
• W2097908085 hasConceptScore W2097908085C2779384505 @default.
• W2097908085 hasConceptScore W2097908085C2781156865 @default.
• W2097908085 hasConceptScore W2097908085C502942594 @default.
• W2097908085 hasConceptScore W2097908085C509974204 @default.
• W2097908085 hasConceptScore W2097908085C71924100 @default.
• W2097908085 hasIssue "4" @default.
• W2097908085 hasLocation W20979080851 @default.
• W2097908085 hasLocation W20979080852 @default.
• W2097908085 hasOpenAccess W2097908085 @default.
• W2097908085 hasPrimaryLocation W20979080851 @default.

• next