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- W2097908259 abstract "Human patients with a variety of malignant tumors have been studied to characterize the reported abnormality of leukotactic function. A majority of patients show a leukotactic defect that is serum associated and due to the presence of an inhibitor. This inhibitor impairs both neutrophil and monocyte reactivity to a variety of leukotactic factors. Phagocytic ability of leukocytes is also impaired by cancer serum and by the fractions of serum rich in the leukotactic inhibitor. The leukotactic inhibitor is cell directed in its function, is heat-stable and can be precipitated from serums with ammonium sulfate. Its sedimentation coefficient is biphasic, with values of approximately 7S and 10S. A similar or identical inhibitor is present in much lower concentration or activity in normal human serum. The presence in cancer serum of this leukotactic inhibitor may account for the well-known defects in the ability of cancer patients to express cellular inflammatory reactions." @default.
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- W2097908259 date "1978-02-01" @default.
- W2097908259 modified "2023-10-11" @default.
- W2097908259 title "Serum-associated inhibition of leukotaxis in humans with cancer" @default.
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- W2097908259 doi "https://doi.org/10.1016/0090-1229(78)90068-5" @default.
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