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- W2097908548 endingPage "60" @default.
- W2097908548 startingPage "52" @default.
- W2097908548 abstract "The neuropeptide galanin (GAL) is up-regulated following neuronal axotomy or inflammation. Since other neuropeptides act as immunomodulatory agents, we sought to determine whether GAL might affect the murine microglial cell line BV2, which expresses the GAL2 receptor. Even at very low concentrations, GAL inhibited tumor necrosis factor-alpha (TNF alpha) release but not TNF alpha mRNA levels in LPS-stimulated BV2 cells. Northern blot analysis showed that GAL inhibited the addition of a poly(A) tail, and stability assays showed that it also destabilized TNF alpha mRNA. Thus, GAL inhibits TNF alpha production by a post-transcriptional mechanism that both prevents the efficient addition of the poly(A) tail and accelerates TNF alpha mRNA degradation." @default.
- W2097908548 created "2016-06-24" @default.
- W2097908548 creator A5011283323 @default.
- W2097908548 creator A5011756139 @default.
- W2097908548 creator A5020844761 @default.
- W2097908548 creator A5035475506 @default.
- W2097908548 date "2003-01-01" @default.
- W2097908548 modified "2023-09-27" @default.
- W2097908548 title "Galanin down-regulates microglial tumor necrosis factor-α production by a post-transcriptional mechanism" @default.
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