FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097908856> ?p ?o ?g. }

• W2097908856 endingPage "3188" @default.
• W2097908856 startingPage "3184" @default.
• W2097908856 abstract "Since the antithrombin action of heparin fails to interrupt arterial thrombosis, a mediating role for thrombin (EC 3.4.21.5) in the formation of high-shear platelet-dependent thrombus has been unproven. To determine whether thrombin is important in acute arterial thrombus formation and to assess the therapeutic potential of inhibiting its action, the effects of the synthetic covalent antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone (FPRCH2Cl) on arterial-flow vascular graft thrombosis and occlusion have been studied in a nonhuman primate model. Continuous intravenous infusion of FPRCH2Cl (100 nmol/kg per min) into vascular graft-bearing baboons (Papio anubis) abolished (i) vascular graft 111In-platelet deposition, (ii) vascular graft occlusion, (iii) thrombus-associated in vivo release of platelet-specific proteins and fibrinopeptides, (iv) platelet hemostatic plug formation, (v) thrombin-induced platelet aggregation ex vivo, and (vi) thrombin-induced blood clotting. The effects of FPRCH2Cl largely disappeared within 15 min after the infusion had been discontinued. FPRCH2Cl produced no detectable cardiovascular or other acute side effects. In contrast, sustained comparably anticoagulating levels of heparin had no effect upon 111In-platelet graft deposition, graft occlusion, platelet function as measured by the bleeding time, platelet aggregation ex vivo, or release of platelet-specific proteins in vivo. We conclude that thrombin is the principal mediator of platelet-dependent hemostatic plug formation and of the formation of platelet-dependent high-flow acute graft thrombosis and occlusion. Moreover, FPRCH2Cl or other synthetic antithrombins may provide effective antithrombotic therapy for both arterial and venous thrombosis by simultaneously inhibiting platelet activation and fibrin formation." @default.
• W2097908856 created "2016-06-24" @default.
• W2097908856 creator A5027011914 @default.
• W2097908856 creator A5047037554 @default.
• W2097908856 date "1988-05-01" @default.
• W2097908856 modified "2023-09-27" @default.
• W2097908856 title "Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone." @default.
• W2097908856 cites W139363061 @default.
• W2097908856 cites W147525296 @default.
• W2097908856 cites W1492493764 @default.
• W2097908856 cites W1497264889 @default.
• W2097908856 cites W1549461809 @default.
• W2097908856 cites W1608933197 @default.
• W2097908856 cites W1977417712 @default.
• W2097908856 cites W1981808231 @default.
• W2097908856 cites W1982730850 @default.
• W2097908856 cites W2005748768 @default.
• W2097908856 cites W2016094241 @default.
• W2097908856 cites W2016716370 @default.
• W2097908856 cites W2025532828 @default.
• W2097908856 cites W2030328556 @default.
• W2097908856 cites W2051256380 @default.
• W2097908856 cites W2055306724 @default.
• W2097908856 cites W2055739022 @default.
• W2097908856 cites W2060297306 @default.
• W2097908856 cites W2075059983 @default.
• W2097908856 cites W2112799238 @default.
• W2097908856 cites W2130398439 @default.
• W2097908856 cites W2152303123 @default.
• W2097908856 cites W2259617251 @default.
• W2097908856 cites W2322148932 @default.
• W2097908856 cites W2398122224 @default.
• W2097908856 cites W2407062076 @default.
• W2097908856 cites W2409231129 @default.
• W2097908856 cites W2410009650 @default.
• W2097908856 cites W2418890452 @default.
• W2097908856 doi "https://doi.org/10.1073/pnas.85.9.3184" @default.
• W2097908856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/280168" @default.
• W2097908856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3362867" @default.
• W2097908856 hasPublicationYear "1988" @default.
• W2097908856 type Work @default.
• W2097908856 sameAs 2097908856 @default.
• W2097908856 citedByCount "237" @default.
• W2097908856 countsByYear W20979088562012 @default.
• W2097908856 countsByYear W20979088562013 @default.
• W2097908856 countsByYear W20979088562014 @default.
• W2097908856 countsByYear W20979088562015 @default.
• W2097908856 countsByYear W20979088562016 @default.
• W2097908856 countsByYear W20979088562018 @default.
• W2097908856 countsByYear W20979088562019 @default.
• W2097908856 countsByYear W20979088562020 @default.
• W2097908856 crossrefType "journal-article" @default.
• W2097908856 hasAuthorship W2097908856A5027011914 @default.
• W2097908856 hasAuthorship W2097908856A5047037554 @default.
• W2097908856 hasBestOaLocation W20979088562 @default.
• W2097908856 hasConcept C126322002 @default.
• W2097908856 hasConcept C150903083 @default.
• W2097908856 hasConcept C185592680 @default.
• W2097908856 hasConcept C202751555 @default.
• W2097908856 hasConcept C207001950 @default.
• W2097908856 hasConcept C26291073 @default.
• W2097908856 hasConcept C2777292125 @default.
• W2097908856 hasConcept C2777557582 @default.
• W2097908856 hasConcept C2779026020 @default.
• W2097908856 hasConcept C2780009322 @default.
• W2097908856 hasConcept C2780868729 @default.
• W2097908856 hasConcept C2781362458 @default.
• W2097908856 hasConcept C2993802102 @default.
• W2097908856 hasConcept C3018697912 @default.
• W2097908856 hasConcept C42219234 @default.
• W2097908856 hasConcept C55493867 @default.
• W2097908856 hasConcept C71924100 @default.
• W2097908856 hasConcept C86803240 @default.
• W2097908856 hasConcept C89560881 @default.
• W2097908856 hasConcept C98274493 @default.
• W2097908856 hasConceptScore W2097908856C126322002 @default.
• W2097908856 hasConceptScore W2097908856C150903083 @default.
• W2097908856 hasConceptScore W2097908856C185592680 @default.
• W2097908856 hasConceptScore W2097908856C202751555 @default.
• W2097908856 hasConceptScore W2097908856C207001950 @default.
• W2097908856 hasConceptScore W2097908856C26291073 @default.
• W2097908856 hasConceptScore W2097908856C2777292125 @default.
• W2097908856 hasConceptScore W2097908856C2777557582 @default.
• W2097908856 hasConceptScore W2097908856C2779026020 @default.
• W2097908856 hasConceptScore W2097908856C2780009322 @default.
• W2097908856 hasConceptScore W2097908856C2780868729 @default.
• W2097908856 hasConceptScore W2097908856C2781362458 @default.
• W2097908856 hasConceptScore W2097908856C2993802102 @default.
• W2097908856 hasConceptScore W2097908856C3018697912 @default.
• W2097908856 hasConceptScore W2097908856C42219234 @default.
• W2097908856 hasConceptScore W2097908856C55493867 @default.
• W2097908856 hasConceptScore W2097908856C71924100 @default.
• W2097908856 hasConceptScore W2097908856C86803240 @default.
• W2097908856 hasConceptScore W2097908856C89560881 @default.
• W2097908856 hasConceptScore W2097908856C98274493 @default.
• W2097908856 hasIssue "9" @default.
• W2097908856 hasLocation W20979088561 @default.
• W2097908856 hasLocation W20979088562 @default.

• next